Tuberculous pericarditis presenting as massive haemorrhagic pericardial effusion

Lee, Vivien Yan Chi; Wong, John Tai Hung; Fan, Hon Cheung; Yeung, Vincent

doi:10.1136/bcr.03.2012.5967

Cited by 9 publications

(8 citation statements)

References 16 publications

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“…Without the mentioned criteria, the diagnosis was only possible by the evidence of caseous granulomas on the pleural biopsy. Although culture is the gold standard for TB diagnosis, caseous necrosis has a high specificity for the disease, and its presence could justify the initiation of antituberculous therapy [4,5]. Diagnosis of extrapulmonary TB is considered a problematic process due to the paucibacillary nature of the specimens, lack of adequate clinical sample volumes and localization of disease in sites that are difficult to access [6].…”

Section: Discussionmentioning

confidence: 99%

Heart failure as a first sign of disseminated tuberculosis

Naia

Rabadão

Teixeira

et al. 2021

Journal of Community Hospital Internal Medicine Perspectives

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Tuberculous pericarditis is a rare extra-pulmonary manifestation of tuberculosis observed mainly in developed countries. It usually presents with concomitant tuberculous infection at a different site and, due to the lack of clinical specificity, diagnosis can be difficult. Thus, a diagnostic delay is frequent, entailing increased morbidity and mortality. The authors present a case of disseminated tuberculosis with predominantly cardiac symptoms with multiple negative samples for Mycobacterium tuberculosis, which evolved to constrictive pericarditis. With this case report, the authors emphasize the demand for a high index of suspicion for achieving a diagnosis and the importance of a multidisciplinary approach.

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Section: Discussionmentioning

confidence: 99%

Heart failure as a first sign of disseminated tuberculosis

Naia

Rabadão

Teixeira

et al. 2021

Journal of Community Hospital Internal Medicine Perspectives

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“…Affected patients usually present with fever, weight loss, cough, night sweating but also with acute cardiac tamponade, albeit rare [6]. Four phases of tbc pericarditis have been described: 1) the dry phase when early immune response takes place and fibrin material's exudation develops; 2) the effusive phase when a serosanguinous fluid is formed; 3) the absorption phase when pericardial thickening and granulomatous caseation organize; and 4) the constrictive phase [7]. The diagnosis of the condition requires pericardial fluid or tissue analysis.…”

Section: Discussionmentioning

confidence: 99%

A case of tuberculosis pericarditis with an interesting echocardiographic image

Taner¹,

Efe²,

Ayça³

et al. 2018

Med Ultrason

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Tuberculosis-associated pericardial disorders are an excessively rare manifestation of extrapulmonary tuberculosis. The patients may present with constrictive pericarditis or pericardial fluid accumulation leading to cardiac tamponade. This paper reports a case of tuberculosis-associated pericardial effusion with dense fibrinous material not causing tamponade in a foreigner presenting with nonspecific symptoms. It also provides a discussion about the diagnostic and therapeutic methods as well as interesting echocardiographic images of the patient.

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“…M. tuberculosis complex include pathogens causing the classical M. tuberculosis, M. bovis, M. afri-canum,M. microti, as well as the newly recognized MTBC members, M. pinniped and M. caprae species [22][23][24]. Even with evolution, M. tuberculosis remains one of the most established pathogens known to humans inspire the availability of its treatment, vaccine and antimicrobial agents.…”

Section: Discussionmentioning

confidence: 99%

Molecular Methods of Testing Tuberculosis Resistant to Antibiotics in Patients Infected in Indore, M.P India

Rupal¹

2018

NTNF

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Objective: Our objective of the work was to identify the type of Mycobacterium at species level with an aim to diagnose and treat the resistant strains by using MDR strains in infecting in patients to identify the infecting Mycobacterium and to find resistance at the level of genes tested using molecular biology of line probe assay methods. Design:We tested various samples for Mycobacterium by using microbiology and molecular biology method of TB-TMA from clinical suspects. With use of Amplification of gene and line arrays of bacteria we determined the susceptibility character of drugs of infecting Mycobacteria in the patients. Results:We were able to identify Mycobacterium tuberculosis by measuring the activity at Promoter level of Mycobacteria and determined their first and send line of drug sensitivity using molecular biological tools of drug susceptibility of MDR and XDR sure methods developed by us. We could detect mutations in repo B gene imparting drug resistance to Rifampicin or Kat G gene and In A gene to Isoniazid from patients' samples infected with Mycobacterial species or resistance to fluoroquinolone, by detecting mutations in gyrA gene and rrs gene that imparts resistance of bacteria to injectable antibiotics. We were able to also Identify Mycobacterium Other Then Tuberculosis (MOTT) Material and methods Samples:We obtained samples of clinical TB suspects from various multispecialized hospitals in our Norquest laboratory at Central lab, Indore (M.P). These patients were recorded in the hospitals and tested using medical, for treatment of patients. The clinical suspects were tested by medical specialists to have pulmonary or extra pulmonary TB, tested by medical methods like chest radiography, C.T scan, pleural tap and CBC tests and dispatched. The samples were transported immediately to our laboratory under cold temperature conditions. Both the pulmonary as well as extra pulmonary samples were analyzed in our laboratory for diagnosis of tuberculosis. For Drug. Sensitivity test three consecutive early morning sputum samples were collected by laboratory technologist, according to protocol in our NABL accredited, Central lab-Norquest, Indore. The samples were processed on the same day or were kept at +4ᵒC till processed. The Medical diagnosis of suspects was done by medical specialists. And M. tuberculosis was detected using TB-TMA method to identify the infecting bacteria as described earlier. Conclusion:We found great variations in the genes of Mycobacterium infecting patients tested in our lab. We were able to find drug sensitivity or resistance of each bacteria infecting, which proved out to be very useful for Clinicians for prescription of the drug regimen based on the infecting bacteria in individual patient according to type of species the patient is infected with Multidrug-resistant tuberculosis (MDR-TB) is tuberculosis disease caused by organisms, which show different level of resistance to Isoniazid or Rifampicin, which may not show resistance to other anti-TB drugs. With increase in MDR TB ...

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Tuberculous pericarditis presenting as massive haemorrhagic pericardial effusion

Cited by 9 publications

References 16 publications

Heart failure as a first sign of disseminated tuberculosis

Heart failure as a first sign of disseminated tuberculosis

A case of tuberculosis pericarditis with an interesting echocardiographic image

Molecular Methods of Testing Tuberculosis Resistant to Antibiotics in Patients Infected in Indore, M.P India

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