Tuberculous Panophthalmitis with Lymphadenitis and Central Nervous System Tuberculoma

Srichatrapimuk, Sirawat; Wattanatranon, Duangkamon; Sungkanuparph, Somnuek

doi:10.1155/2016/6785382

Cited by 7 publications

(3 citation statements)

References 34 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Those included: CNS, abdominal and peritoneal, pericardial and adrenal. 19,21,27,28,31,37,53 Treatment regimens varied from case-to-case and included medications like rifampin, isoniazid, pyrazinamide and ethambutol, among others. The reported mortality in this series was low (1 case) but this could be due to under-reporting as follow-up duration varied significantly from study to study.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

<p>Endogenous Tuberculous Endophthalmitis and Panophthalmitis: A Systematic Review of Case Reports and Case Series</p>

Antaki¹,

Javidi²,

Touma³

et al. 2020

OPTH

View full text Add to dashboard Cite

To systematically review the characteristics of patients with endogenous tuberculous (TB) endophthalmitis and panophthalmitis in an effort to help clinicians with diagnosis and treatment. Patients and Methods: We conducted a systematic literature search in MEDLINE/ PubMed, EMBASE and Web of Science from inception to August 2020. References and abstracts were screened independently by two authors. Included studies were case reports and case series reporting endogenous TB endophthalmitis and panophthalmitis secondary to Mycobacterium tuberculosis complex (MTBC). Available-case analysis was employed to handle missing data. Results: A total of 1343 articles were found using the search strategy. Following abstract screening, 51 articles were selected for full text-review, from which 26 were deemed eligible for inclusion in the study. Forty-four cases from 26 articles were included in the quantitative analysis. The median age of presentation was 29.5 (range: 1 to 81), and 11/44 patients (25.0%) were pediatric. Immunosuppression was seen in 9/36 cases (25.0%). Most patients (24/38, 63.2%) had no prior history of tuberculosis. Systemic symptoms were absent in half of the patients (16/32, 50.0%). Visual acuity was poor, with 23/27 cases (85.2%) being 20/ 200 or worse at presentation. Poor organ and visual outcomes were reported: 36/43 cases (83.7%) resulted in enucleation/evisceration or exenteration. Intraocular tumors were suspected in 5/34 cases (14.7%). Pulmonary tuberculosis was seen in 15/35 cases (42.8%), and miliary tuberculosis was seen in 7/35 cases (20.0%). The earliest source of TB diagnosis was through histopathologic specimen after eye removal in 32/44 cases (72.7%), vitreous specimen in 6/44 cases (13.6%) and aqueous specimen in 3/44 cases (6.8%). Conclusion: TB endophthalmitis is a rare and sight-threatening manifestation of ocular tuberculosis. It can occur in apparently healthy individuals and can mimic intraocular tumors and other infectious etiologies. Diagnosis remains a significant challenge, which, often delayed, leads to profound visual loss. Early detection and treatment of intraocular tuberculosis may be associated with better ocular and systemic outcomes.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Six patients had HIV with low CD4 count (range: 34-263 cell/mm 3 ). [18][19][20][21] One was known for Waldenström's macroglobulinemia (WM) and rituximabassociated hypogammaglobulinemia. 22 Two patients were on immunosuppressive therapy for systemic sarcoidosis and systemic lupus erythematosus.…”

Section: Demographic Data and Past Medical Historymentioning

confidence: 99%

<p>Endogenous Tuberculous Endophthalmitis and Panophthalmitis: A Systematic Review of Case Reports and Case Series</p>

Antaki¹,

Javidi²,

Touma³

et al. 2020

OPTH

View full text Add to dashboard Cite

show abstract

“…Most reports of TB panophthalmitis in HIV/AIDS have been reported in association with extensive systemic TB. [ 10 ]…”

Section: Discussionmentioning

confidence: 99%

Tubercular panophthalmitis in a patient with human immunodeficiency virus infection: Proven clinicopathologically and by molecular diagnostic tests

Pradeep

Nair

Sridharan

et al. 2020

Indian J Ophthalmol

View full text Add to dashboard Cite

Ocular tuberculosis (OTB) in patients with human immunodeficiency virus (HIV) commonly presents as choroidal tubercles or granuloma. We report a rare presentation of OTB with hypopyon granulomatous uveitis in a patient with HIV on highly active antiretroviral therapy (HAART). Aqueous humor polymerase chain reaction (PCR) was positive for Mycobacterium tuberculosis (MTB). Antitubercular therapy (ATT) was initiated despite which it progressed to scleral abscess and panophthalmitis. Enucleation with ball implantation was done. Histopathology revealed caseating granuloma with numerous acid-fast bacilli (AFB) and real-time PCR showed increased copies of MTB genome. After a full course of ATT, he had stable ocular and systemic condition at final follow-up.

show abstract

Tubercular Uveitis

Kumar¹,

Chawla²,

Ravani³

et al. 2017

Essentials in Ophthalmology

View full text Add to dashboard Cite

Tuberculous Panophthalmitis with Lymphadenitis and Central Nervous System Tuberculoma

Cited by 7 publications

References 34 publications

<p>Endogenous Tuberculous Endophthalmitis and Panophthalmitis: A Systematic Review of Case Reports and Case Series</p>

<p>Endogenous Tuberculous Endophthalmitis and Panophthalmitis: A Systematic Review of Case Reports and Case Series</p>

Tubercular panophthalmitis in a patient with human immunodeficiency virus infection: Proven clinicopathologically and by molecular diagnostic tests

Tubercular Uveitis

Contact Info

Product

Resources

About