Tuberculous pancreatitis

Knowles, Kathleen; Saltman, D.; Robson, Hugh G.; Lalonde, Richard

doi:10.1016/0041-3879(90)90064-f

Cited by 37 publications

(25 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Intraparenchymal injection of M. tuberculosis causes destructive lesions only if an enormous amount of inoculum is used. Furthermore, an antimycobacterial effect from pancreatic extracts and purified lipases and deoxyribonucleases has been reported [5]. De Backer et al…”

Section: Discussionmentioning

confidence: 97%

“…Other possible mechanisms are abdominal contamination by M. tuberculosis as a result of ingestion of infected material from an active pulmonary focus with subsequent lymphatic spread; reactivation of a previously latent pancreatic tuberculosis induced by alcoholism, pancreatitis, treatment with steroids, or surgical manipulation; and direct extension through the pancreas from adjacent organs such as contiguous lymph nodes. Finally, a toxic-allergic reaction of the pancreas as a result of generalized tuberculosis, probably reflecting a nonspecific inflammatory host response to mycobacterial antigens rather than an infection per se, has also been suggested [5,6]. In our patients, concomitant pancreatitis or toxic-allergic reaction to systemic tuberculosis seemed unlikely because laboratory evaluation showed normal levels of serum amylase and lipase, and the signal intensities of the peripancreatic and paraaortic lymph nodes were comparable to those of the affected portions of the gland.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Tuberculosis of the Pancreas: MRI Features

Backer

Mortelé

Bomans

et al. 2005

American Journal of Roentgenology

View full text Add to dashboard Cite

Pancreatic tuberculosis can be focal or diffuse. If focal, it presents as a sharply delineated mass located in the pancreatic head, showing heterogeneous enhancement. Lesions are hypointense on fat-suppressed T1-weighted images and a mixture of hypo- and hyperintense on T2-weighted images. The appearances of common bile duct and main pancreatic duct are normal. Diffuse involvement is characterized by pancreatic enlargement with narrowing of the main pancreatic duct and heterogeneous enhancement. Signal intensity abnormalities indicating diffuse involvement include hypointensity on fat-suppressed T1-weighted images and hyperintensity on T2-weighted images.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 98%

Tuberculosis of the Pancreas: MRI Features

Backer

Mortelé

Bomans

et al. 2005

American Journal of Roentgenology

View full text Add to dashboard Cite

show abstract

“…The role of antibacterial pancreatic factors has also been proposed as a factor responsible for rare occurrence of pancreatic tuberculosis. Also, an antimycobacterial effect from pancreatic extracts and purified lipases and deoxyribonucleases has been reported [56].…”

Section: Pathogenesismentioning

confidence: 99%

Pancreatic Tuberculosis

2015

View full text Add to dashboard Cite

Tuberculosis of the pancreas is extremely rare and in most of the cases mimics pancreatic carcinoma. There are a number of case reports on pancreatic tuberculosis with various different presentations, but only a few case series have been published, and most of our knowledge about this disease comes from individual case reports. Patients of pancreatic tuberculosis may remain asymptomatic initially and manifest as an abscess or a mass involving local lymph nodes and usually present with non-specific features. Pancreatic tuberculosis may present with a wide range of imaging findings. It is difficult to diagnose tuberculosis of pancreas on imaging studies as they may present with masses, cystic lesions or abscesses and mass lesions in most of the cases mimic pancreatic carcinoma. As it is a rare entity, it cannot be recommended but suggested that pancreatic tuberculosis should be considered in cases with a large space occupying lesions associated with necrotic peripancreatic lymph nodes and constitutional sympt o m s . U l t r a s o n o g r a p h y / c o m p u t e d t o m o g r a p h y / endosonography-guided biopsy is the recommended diagnostic technique. Most patients achieve complete cure with standard antituberculous therapy. The aims of this study are to review clinical presentation, diagnostic studies, and management of pancreatic tuberculosis and to present our experience of 5 cases of pancreatic tuberculosis.

show abstract

“…Several mechanisms have been proposed to explain pancreatic infection by TB. Contiguous spread from adjacent lymph nodes is felt to be most likely but direct hematogenous seeding has also been proposed (15,16). The pancreas is relatively resistant to infection by TB.…”

Section: Discussionmentioning

confidence: 98%