Tuberculous myositis and cellulitis in a renal transplant recipient

Anand, S. Murugesh; Fernando, M Edwin; Srinivasaprasad, ND; Sujit, S; Thirumalvalavan, K

doi:10.1016/j.ijtb.2019.04.010

Cited by 6 publications

(8 citation statements)

References 6 publications

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“…To date, there have been 7 clinical reports of tuberculous cellulitis in adult patients, including our case ( Table I ). 1 , 3 , 4 , 5 , 6 , 7 All patients were immunosuppressed. Six received steroid therapy, including 3 patients with collagen vascular disease, 4 , 5 1 with diabetes, 1 1 with chronic hepatitis, 3 and a renal transplant recipient.…”

Section: Discussionmentioning

confidence: 99%

“…Six received steroid therapy, including 3 patients with collagen vascular disease, 4 , 5 1 with diabetes, 1 1 with chronic hepatitis, 3 and a renal transplant recipient. 7 The extremities were affected in 6 of the 7 patients, 3 , 4 , 5 , 6 , 7 and most developed concomitant bacterial superinfection. Several studies have reported severe tuberculous cellulitis causing erosions and ulcers and myositis, depending on the depth of invasion.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have reported severe tuberculous cellulitis causing erosions and ulcers and myositis, depending on the depth of invasion. 5 , 6 , 7 …”

Section: Discussionmentioning

confidence: 99%

“…Several cases of atypical CTB have been reported in adults. 1 , 3 , 4 , 5 , 6 , 7 We present a rare case of ulcerative tuberculous cellulitis in a patient with methotrexate-associated lymphoproliferative disorder (MTX-LPD.)…”

Section: Introductionmentioning

confidence: 99%

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A case of ulcerative tuberculous cellulitis in the setting of methotrexate-associated lymphoproliferative disorder

et al. 2022

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Several studies have reported severe tuberculous cellulitis causing erosions and ulcers and myositis, depending on the depth of invasion. 5 , 6 , 7 …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A case of ulcerative tuberculous cellulitis in the setting of methotrexate-associated lymphoproliferative disorder

et al. 2022

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“…Moreover, extrapulmonary TB such as meningitis, spondylitis, genitourinary TB, intestinal TB, and tubercular lymphadenitis have been reported in SOT patients. Rare presentations such as arthritis, tenosynovitis, cutaneous ulcers, and pyomyositis have also been reported [ 16 , 18 , 19 ].…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Mycobacterial infections in solid organ transplant recipients

Rashid

Begum

Kashem

2021

Korean J Transplant

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Mycobacterium tuberculosis (MTB) infection in solid organ transplant (SOT) recipients remains a major challenge for physicians and surgeons. Active tuberculosis (TB) is associated with increased morbidity and mortality in SOT recipients. MTB usually develops after transplantation in a recipient with latent TB infection (LTBI) before transplantation and may also be transmitted from the donor or acquired from the community. Therefore, screening for LTBI in donors and recipients before transplantation is very important in preventing active disease after transplantation. This review article is based on recently published data, case series, and expert recommendations. We reviewed updated information about the epidemiology, diagnosis, and treatment of latent and active TB before and after transplantation. We also reviewed recent treatments for multidrug-resistant TB.

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Primary Tuberculous Myositis—Report of a Case and Systematic Review of Literature in the Last 25 Years

et al. 2020

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M ycobacterium tuberculosis infects approximately 1.7 billion people in the world and causes disease in 10 million annually. Musculoskeletal tuberculosis accounts for 2% to 5% of cases, generally presenting as Pott's spine or large joint arthritis 1 ; the involvement of muscle by tubercle bacilli, referred to as tuberculous myositis, is rare. Muscle involvement can occur either due to hematogenous spread (primary) or as a result of extension from a contiguous site (secondary); the former being less common. 2 We report a case of primary tuberculous myositis and review all cases published in the last 25 years. CASE REPORTA 49-year-old man was admitted with swelling and dullaching pain over the right gluteal region, fever, and loss of appetite for 6 months. Three years prior to the current presentation, he had been diagnosed with dermatomyositis and treated with corticosteroids and azathioprine; these drugs were tapered and stopped after 2 years. With a possibility of relapse, corticosteroids were restarted 1 month before his admission.On examination, a localized tender swelling was present over the right gluteal area and posterior thigh, extending to the knee. Magnetic resonance imaging of this region revealed active myositis of the gluteal muscle and muscles in the posterior compartment of the right thigh (Figs. 1A, B). Positron emission tomographycomputed tomography showed uptake in these muscles, and an image-guided biopsy was performed. This revealed granulomatous inflammation on histopathology (Fig. 2), and a cartridge-based nucleic acid amplification test GeneXpert MTB/RIF (Cepheid, Sunnyvale, CA) detected M. tuberculosis. Computed tomography of the thorax did not show any pulmonary tuberculosis; however, tuberculin skin test was positive. Antitubercular therapy was started with isoniazid, rifampicin, ethambutol, and pyrazinamide for 2 months, followed by isoniazid, rifampicin, and ethambutol for 8 months. The fever resolved within 2 weeks, and over the next few months, the swelling subsided, and the patient gained weight. At 1 year, he was found to be asymptomatic and disease-free. METHODS FOR SYSTEMATIC REVIEWWe carried out a search in PubMed (MEDLINE), Scopus, EMBASE, and Web of Science, using the words "tubercular myositis," "tubercular pyomyositis," "tuberculous myositis," or "tuberculous pyomyositis." This review was restricted to articles in English language that were published between January 1995 and December 2019. Abstracts and full texts of relevant articles were examined by 2 authors (H.S., V.D.), and those articles that described cases of primary tuberculous myositis confirmed by microbiological tests (or on histopathology) were included for review. The outcome of cases was noted, factors associated with death analyzed, and odds ratios (ORs) (95% confidence intervals [CIs]) calculated. Analysis was done by GraphPad Prism (version 8 for Windows, La Jolla, CA).

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Tuberculous myositis and cellulitis in a renal transplant recipient

Cited by 6 publications

References 6 publications

A case of ulcerative tuberculous cellulitis in the setting of methotrexate-associated lymphoproliferative disorder

A case of ulcerative tuberculous cellulitis in the setting of methotrexate-associated lymphoproliferative disorder

Mycobacterial infections in solid organ transplant recipients

Primary Tuberculous Myositis—Report of a Case and Systematic Review of Literature in the Last 25 Years

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