Tuberculous meningitis

Ruziczka, O

doi:10.1016/s0022-3476(52)80068-x

Cited by 7 publications

(1 citation statement)

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“…There is only one point of agreement: the necessity of starting the treatment as early as possible. But opinions are still very divided as to what concerns the dosage of streptomycin, the route of its administration, either intramuscular and intrathecal or intramuscular aloDe, the use of adjuvants, PAS and isoniazid in association with streptomycin or alone, the association of sulfones or of hormones as cortisone or ACTH (2,7,9,ID,Il,13,14,15,17,20,21,22,25,32,33,34,35,36,41,52,54,55,60,63,64,65,71,72,75,76,77,80,82,85,88,89,90,91,97,99,102,104,109,110,112,114,116,119,120).…”

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confidence: 99%

THE ISOLATION OF MYCOBACTERIUM TUBERCULOSIS BY FILTRATION TECHNIQUE FROM CEREBROSPINAL FLUID

Morgante¹,

Murray²

1955

Can. J. Microbiol.

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Collection on a filter membrane as a routine culture method has proved of great advantage in the isolation of Mycobacterium tuberculosis from the cerebrospinal fluid. Its use, during combined intrathecal treatment with streptomycin and Purified Protein Derivative of tuberculin, shows that the organisms persist for an unexpectedly long time in the cerebrospinal fluid. In some instances, focal reaction to P.P.D. seems to liberate tubercle bacilli from the lesions into the fluid. Direct culture of C.S.F. on Loewenstein medium gave less than two positive specimens per patient and no positive cultures later than the second week of treatment. Filtration gave more profuse growth and persistence of positive cultures during treatment for as long as 28 weeks in some cases.

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