“…The epididymis being the commonest structure to be involved, followed by the seminal vesicles, prostate, testis, and the vas deferens 2 .Tuberculous orchitis usually occurs as a result of direct extension from the epididymis 3 .Present HIV Pandemic has resulted in a global surge in the TB prevalence which in turn resulted in the surge of extra pulmonary TB in endemic areas 4 Most of the cases are coexist with pulmonary TB or tuberculosis of other parts of lower genitourinary system including bladder, ureter and prostate. Isolated tuberculous epididymitis (TBE) or epididymo-orchitis(TBE-O) is rare 4 Clinically, TBE-O may mimicthe other testicular conditions like bacterial epididymitis, viral orchitis, infected hydrocele, spermatocele, testicular torsion, scrotal trauma, or neoplasm in healthy patients with no clinical symptoms and signs. This diagnostic dilemma may result in aninappropriate surgical procedure for a potentially curable medical illness, which could have been avoided with anti-TB management 5 hence accurate differentiation is important for appropriate treatment.…”