Tuberculous Epididymo‐Orchitis Following Intravesical BCG

Preoperative diagnosis of bilateral tuberculous epididymo‐orchitis following intravesical Bacillus Calmette–Guerin therapy for superficial bladder carcinoma

“…4,5 Significant complications following intravesical BCG therapy occur infrequently, with tuberculous epididymo-orchitis being a very rare complication. [3][4][5][6][7][8][9] To our knowledge, this is the first report of preoperative ultrasonographic diagnosis of tuberculous epididymo-orchitis following intravesical BCG therapy for superficial bladder carcinoma. Awareness of this unusual BCG complication and its ultrasonographic findings can provide accurate diagnosis and proper management.…”

“…Tuberculous epididymo‐orchitis following intravesical BCG therapy is a rare complication. To our knowledge, 10 such cases have been reported in the English literature 3–9 4 reported only two cases of epididymo‐orchitis from the review of 1278 patients undergoing intravesical BCG therapy.…”

“…Orihuela et al 5 reported only one case of epididymitis in a study of 107 patients receiving intravesical BCG treatment. Subsequently, seven cases of epididymo‐orchitis following intravesical therapy have been reported 3,6–9 . Of the 10 reported cases, five received the Pasteur strain of BCG, four received the Tice strain of BCG and one received the Connaught strain of BCG.…”

Necrotizing granulomatous epididymo-orchitis post intravesical BCG administration after brachytherapy for prostate cancer

“…The suspected etiology of BCG-related granulomatous disease has been linked to prior prostate surgery including transurethral resection of the prostate and suprapubic prostatectomy. 4 Additional causes include: vasectomy, transurethral resection of bladder tumor, and infectious causes (tuberculosis, rickettsia, brucellosis. Sarcoidosis, fungal infection.)…”

Multiparametric ultrasound findings of tuberculous orchitis following bacillus Calmette-Guérin therapy

“…A search of the MEDLINE database using the EBSCO search engine yielded up to 15 previously reported cases of epididymo-orchitis as a complication of intravesical BCG therapy [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] . The age range of the patients reported in these articles span between 54 and 83 years, which makes our patient the oldest reported case of BCG-related orchitis.…”