Tuberculous Addison's disease: Morphological and quantitative evaluation with multidetector-row CT

S.K., Edmond; Yang, Zhi‐gang; Li, Yuan; Guo, Yumei; Deng, Yu-Ping; Zhang, Xiaochun

doi:10.1016/j.ejrad.2006.12.012

Cited by 23 publications

(29 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We could not find a reference estimating the frequency of adrenal calcifications seen at CT in the general population, but our experience is that these calcifications are very infrequent, perhaps on the order of one instance in 300–500 CT scans. When seen on CT scans, adrenal calcifications are most commonly attributed to previous hemorrhage, granulomatous disease, and calcified masses (25–27). Hemangiomas occur rarely in the adrenal gland as a known vascular mass and can calcify (26,28).…”

Section: Discussionmentioning

confidence: 99%

Familial Cerebral Cavernous Malformations Are Associated with Adrenal Calcifications on CT Scans: An Imaging Biomarker for a Hereditary Cerebrovascular Condition

et al. 2017

View full text Add to dashboard Cite

Purpose To determine if adrenal calcifications seen at computed tomography (CT) are associated with familial cerebral cavernous malformations (fCCMs) in carriers of the CCM1 Common Hispanic Mutation. Materials and Methods This study was approved by the institutional review board. The authors retrospectively reviewed abdominal CT scans in 38 patients with fCCM, 38 unaffected age- and sex-matched control subjects, and 13 patients with sporadic, nonfamilial cerebral cavernous malformation (CCM). The size, number, and laterality of calcifications and the morphologic characteristics of the adrenal gland were recorded. Brain lesion count was recorded from brain magnetic resonance (MR) imaging in patients with fCCM. The prevalence of adrenal calcifications in patients with fCCM was compared with that in unaffected control subjects and those with sporadic CCM by using the Fisher exact test. Additional analyses were performed to determine whether age and brain lesion count were associated with adrenal findings in patients with fCCM. Results Small focal calcifications (SFCs) (≤5 mm) were seen in one or both adrenal glands in 19 of the 38 patients with fCCM (50%), compared with 0 of the 38 unaffected control subjects (P < .001) and 0 of the 13 subjects with sporadic CCM (P = .001). Adrenal calcifications in patients with fCCM were more frequently left sided, with 17 of 19 patients having more SFCs in the left adrenal gland than the right adrenal gland and 50 of the 61 observed SFCs (82%) found in the left adrenal gland. No subjects had SFCs on the right side only. In patients with fCCM, the presence of SFCs showed a positive correlation with age (P < .001) and number of brain lesions (P < .001). Conclusion Adrenal calcifications identified on CT scans are common in patients with fCCM and may be a clinically silent manifestation of disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Familial Cerebral Cavernous Malformations Are Associated with Adrenal Calcifications on CT Scans: An Imaging Biomarker for a Hereditary Cerebrovascular Condition

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Among infectious disorders, both tuberculosis (TB) and histoplasmosis can involve the adrenal gland [11][12][13][14][15]. In addition to the morbidity associated with these systemic infections, if most (> 90%) of the gland is destroyed, patients develop Addison's disease [11,14].…”

Section: Infectionmentioning

confidence: 99%

“…In addition to the morbidity associated with these systemic infections, if most (> 90%) of the gland is destroyed, patients develop Addison's disease [11,14].…”

Section: Infectionmentioning

confidence: 99%

Section: Infectionmentioning

confidence: 99%

“…Most patients have bilateral gland enlargement, masslike in 50-65% and adreniform in 35-50% [11,12,14]. Unenhanced CT shows attenuation to be more commonly homogeneous, but one third are heterogeneous [14]. After contrast infusion, the classic appearance of peripheral enhancement with central necrosis is seen in 40-50% of cases; alternatively, the glands may enhance heterogeneously [11,14].…”

Section: Infectionmentioning

confidence: 99%

See 2 more Smart Citations