Tuberculosis

Rajagopalan, Shobita; Yoshikawa, Thomas T.

doi:10.1002/9781119952930.ch115

Pathy's Principles and Practice of Geriatric Medicine 2012

DOI: 10.1002/9781119952930.ch115

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Tuberculosis

Shobita Rajagopalan¹,

Thomas T. Yoshikawa²

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2022

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Cited by 1 publication

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Compelling Cyclic Peptide Scaffolds for Antitubercular Action: An Account (2011-21) of the Natural Source

Bandyopadhyay

Chowdhury

2022

CPPS

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Natural cyclic peptide scaffolds are indispensable in medicinal chemistry, chemical biology, and drug discovery platforms due to their chemical diversity, structural integrity, proteolytic stability and biocompatibility. Historically, their isolation and profound understanding of target engagement have been identified as lead pharmacophore discovery. Cyclic peptides are the largest class of pharmacologically active peptides, in which most show activity against drug-resistant Mycobacterium tuberculosis (Mtb). Nevertheless, eight recently discovered cyclic peptide scaffolds exhibit promising antitubercular activity among numerous naturally occurring antitubercular peptides, and they are amenable scaffolds to drug development. We examined their biological origin, scaffolds, isolations, chemical synthesis, and reasons for biological actions against Mtb. Understanding these peptide scaffold details will further allow synthetic and medicinal chemists to develop novel peptide therapeutics against tuberculosis-infected deadly diseases. This review emphasizes these cyclic peptides' in vitro and in vivo activity profiles, including their structural and chemical features.

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Compelling Cyclic Peptide Scaffolds for Antitubercular Action: An Account (2011-21) of the Natural Source

Bandyopadhyay

Chowdhury

2022

CPPS

View full text Add to dashboard Cite

show abstract

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Tuberculosis

Cited by 1 publication

References 15 publications

Compelling Cyclic Peptide Scaffolds for Antitubercular Action: An Account (2011-21) of the Natural Source

Compelling Cyclic Peptide Scaffolds for Antitubercular Action: An Account (2011-21) of the Natural Source

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