Tuberculosis of the spine

Leowattana, Wattana; Leowattana, Pathomthep; Leowattana, Tawithep

doi:10.5312/wjo.v14.i5.275

Cited by 10 publications

(5 citation statements)

References 100 publications

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“…The reason for such a low success rate in culture could be attributed to the fact that our hospital laboratory concludes culturing after 7 days, while culturing for tuberculosis often requires more than 10 days. 22 Utilizing egg-based or BACTEC 460 TB system could potentially shorten the culture time to around 9 days. 22 To obtain positive culture results, you could either utilize specialized culture media for MTB or extend the culture duration appropriately.…”

Section: Discussionmentioning

confidence: 99%

“… 22 Utilizing egg-based or BACTEC 460 TB system could potentially shorten the culture time to around 9 days. 22 To obtain positive culture results, you could either utilize specialized culture media for MTB or extend the culture duration appropriately. However, mNGS could provide test results within 48 hours of sample acquisition, enabling more efficient early-stage diagnosis compared to culture.…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic Efficacy of Metagenomic Next-Generation Sequencing in Patients with Spinal Infections: A Retrospective Study

Cheng,

Wu,

Tan

et al. 2023

IDR

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Purpose Early diagnosis of spinal infections remains challenging, and emerging metagenomic next-generation sequencing (mNGS) technology holds promise in addressing this issue. The aim of this study is to investigate the diagnostic efficacy of mNGS in spinal infections. Patients and Methods A total of 78 cases with suspected spinal infections were enrolled in this study, all of whom underwent laboratory, histopathological and mNGS examinations upon admission. Lesion samples were obtained by surgical or C-arm-guided puncture. Sensitivity, specificity, positive predictive value and negative predictive value of culture and mNGS were calculated for statistical analysis. Results With histopathological results as the reference, the included 78 patients were categorized into 50 cases in the spinal infection group and 28 cases in the aseptic group. The sensitivity (84%) and negative predictive value (77.14%) of mNGS were significantly higher than those of culture (32% and 44.26%, respectively), whereas no significant differences were observed in terms of specificity and positive predictive value. In the subgroup analysis for Mycobacterium tuberculosis, the sensitivity of mNGS (90.91%) and T-spot (90.91%) was significantly higher than that of culture (0). Additionally, mNGS demonstrated markedly higher specificity (100%) compared to T-spot (85.07%). Conclusion This study underscores the substantial advantages of mNGS in terms of diagnostic accuracy and bacterial coverage for spinal infections. The findings provide compelling clinical evidence that supports the enhanced diagnostic efficacy of mNGS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Diagnostic Efficacy of Metagenomic Next-Generation Sequencing in Patients with Spinal Infections: A Retrospective Study

Cheng,

Wu,

Tan

et al. 2023

IDR

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“…In addition, there is no reliable way to assess the extent of M. TB infection or predict its clinical outcomes. For this reason, the triad of clinical progress, laboratory markers, and radiographic assessment remains the gold standard for confirming healing [88] ( Table 4 ).…”

Section: Defining the Endpoint Of Treatmentmentioning

confidence: 99%

Active tuberculosis of spine: Current updates

Shanmuganathan,

Ramachandran,

Shetty

et al. 2023

North American Spine Society Journal (NASSJ)

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“…Moreover, pyogenic spondylitis tends to involve no more than two vertebral bodies, whereas tuberculous spondylitis often involves multiple vertebral bodies 88 . Infection may spread to contiguous vertebral bodies or skip multiple levels; it commonly spreads beneath the anterior longitudinal ligament (and, less commonly, the posterior longitudinal ligament) 89 (Table 4).…”

Section: Specific Issues When Diagnosing Cns Tb and The Role Of Mrimentioning

confidence: 99%

Pediatric and adult meningeal, parenchymal, and spinal tuberculosis: A neuroimaging review

Mertiri,

Freiling,

Desai

et al. 2023

Journal of Neuroimaging

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Neurotuberculosis is defined as a tuberculous infection of the meninges, brain parenchyma, vessels, cranial and spinal nerves, spinal cord, skull, and spine that can occur either in a localized or in a diffuse form.It is a heterogeneous disease characterized by many imaging appearances and it has been defined as “the great mimicker” due to similarities with many other conditions.The diagnosis of central nervous system (CNS) tuberculosis (TB) is based on clinical presentation, neuroimaging findings, laboratory and microbiological findings, and comprehensive evaluation of the response to anti‐TB drug treatment.However, the absence of specific symptoms, the wide spectrum of neurological manifestations, the myriad of imaging findings, possible inconclusive laboratory results, and the paradoxical reaction to treatment make the diagnosis often challenging and difficult, potentially delaying adequate treatment with possible devastating short‐term and long‐term neurologic sequelae.Familiarity with the imaging characteristics helps in accurate diagnosis and may prevent or limit significantly morbidity and mortality. The goal of this review is to provide a comprehensive up‐to‐date overview of the conventional and advanced imaging features of CNS TB for radiologists, neuroradiologists, and pediatric radiologists. We discuss the most typical neurotuberculosis imaging findings and their differential diagnosis in children and adults with the goal to provide a global overview of this entity.

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Tuberculosis of the spine

Cited by 10 publications

References 100 publications

Diagnostic Efficacy of Metagenomic Next-Generation Sequencing in Patients with Spinal Infections: A Retrospective Study

Diagnostic Efficacy of Metagenomic Next-Generation Sequencing in Patients with Spinal Infections: A Retrospective Study

Active tuberculosis of spine: Current updates

Pediatric and adult meningeal, parenchymal, and spinal tuberculosis: A neuroimaging review

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