Tuberculosis of the Musculoskeletal System

Spiegel, David A.; Singh, Girish Kumar; Banskota, Ashok Kumar

doi:10.1097/01.bto.0000167745.24646.dc

Cited by 55 publications

(65 citation statements)

References 74 publications

(84 reference statements)

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“…Bone changes become apparent after three to five months from initial spinal involvement (Spiegel et al, 2005), with average disease duration ranging from four -11 months to a few years (Garg and Somvanshi, 2011). Compared to pyogenic hematogenous bone diseases, lesions in 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 5 skeletal TB develop slowly, with gradual decalcification of the bone and slow 'poisoning' of the cells (El-Najjar, 1981;Meghji et al, 1997)).…”

Section: Rationale Of the Studymentioning

confidence: 99%

“…In addition, spinal TB is expected to reduce normal activity (and in some cases leads to immobilization) because of symptoms such as weakness or numbness of the lower limbs (due to spinal nerve damage), severe pain, and signs such as an unsteady or abnormal gait (Luk, 1999), and a psoas abscess (Chandler and Page, 1940;Resnick and Niwayama, 1995), respiratory dysfunction (Aufderheide and Rodríguez Martin 1998), and paraplegia with flaccid paralysis (Turgut, 2001;Spiegel et al, 2005).…”

Section: Rationale Of the Studymentioning

confidence: 99%

“…Both individuals display a collapse of the spine due to lytic lesions affecting the lower thoracic and lumbar vertebral bodies. The lesions are typical of tuberculous spondylitis, a form of osteoarticular TB affecting the spine (Spiegel et al, 2005). Individuals who survive spinal TB enter a stage of repair and eventual ankylosis, with re-mineralization of the destroyed vertebrae that often results in a spinal deformity (i.e.…”

Section: Introductionmentioning

confidence: 99%

“…Second, differences in linear growth velocity between the humeri, the femur, and the tibia (Ruff 2003a(Ruff , 2003bSmith and Buschang, 2005) during the time when cross-sectional development was disturbed may have played a role. Finally, it is conceivable that the progressive destruction of the vertebral bodies and common complications of TB, such as weakness of the lower limbs and loss of muscular tone (Chandler and Page, 1940;Resnick and Niwayama, 1995;Turgut, 2001;Spiegel et al, 2005), had a greater impact on the ability to traverse the mountainous Ligurian landscape than on basic manipulative tasks, resulting in a differential level of inhibition of periosteal apposition. …”

mentioning

confidence: 99%

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Insights on the paleoepidemiology of ancient tuberculosis from the structural analysis of postcranial remains from the Ligurian Neolithic (northwestern Italy)

Sparacello

Roberts

Canci

et al. 2016

International Journal of Paleopathology

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Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. Abstract: The aim of this research was to gain insights on the timeline of progression of osteoarticular tuberculosis (TB) in people from the Neolithic period by using skeletal traits that are independent of the bony lesions. The body proportions and postcranial mechanical strength of bones from two individuals from Liguria in northwestern Italy (Arene Candide 5, adolescent, and Arma dell'Aquila 1, adult), were compared with the rest of the Ligurian Neolithic skeletal series (45 individuals). If TB led to wasting of the skeleton and lack of normal function which endured for years, as often happens today, a clear signature of postcranial gracility and disruption of development should be apparent. Conversely, rapid progress of the disease would leave little systemic macroscopic change in the skeleton, except for the bony lesions directly caused by the TB pathogen, suggesting a different level of bacterial virulence in the past. The extreme biomechanical gracility observed in the lower limb of Arene Candide 5 suggests a period of compromised diaphyseal periosteal apposition during ontogeny due to metabolic disturbances likely linked to TB. Results suggest that, in Neolithic Liguria, TB in humans saw a slow, chronic progression, which is characteristic of diseases with long histories of host-pathogen coevolution. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64

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Section: Rationale Of the Studymentioning

confidence: 99%

Section: Rationale Of the Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Insights on the paleoepidemiology of ancient tuberculosis from the structural analysis of postcranial remains from the Ligurian Neolithic (northwestern Italy)

Sparacello

Roberts

Canci

et al. 2016

International Journal of Paleopathology

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“…The primary cause of the deformity of gibbus is unstable lesion and its progressive development. 6 This study aimed to evaluate the correlation between the degree of gibbus angulation and neurological deficits as well as pain.…”

Section: Introductionmentioning

confidence: 99%

Correlation between Degree of Gibbus Angulation, Neurological Deficits, and Pain in Spondylitis Tuberculosis Patients

Hadian

Prasetia

Faried

2017

IJIHS

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Objective: To analyze the correlation between the degree of angulation and neurological deficits as well as pain in spondylitis tuberculosis (TB) patients.Methods: This observational-analytic study included bivariate analysis on data collected from the medical records of patients with presented with spondylitis TB to Dr. Hasan Sadikin General Hospital, Bandung outpatient clinic from January 2014 to December 2015. The variables were the degree of gibbus angulation, neurological deficits, and pain. Results:The study showed significant positive correlation between gibbus angulation and sensory neurological deficits (r=0.375; p=0.009) and there was significant positive correlation between gibbus angulation and pain (r=0.638, p=0.000). The study showed an insignificant correlation between gibbus angulation and motoric neurological deficits (r=0.125; p=0.525). Conclusions:There is a significant correlation between the degree of gibbus angulation and pain as well as sensory neurological deficits. Meanwhile, no significant correlation is found between the degree of gibbus angulation and motoric neurological deficits.

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Knee Ankyloses Associated with Tuberculosis from the Medieval Hungary - Differential Diagnosis Based on Medical Imaging Techniques

Paja

Coqueugniot

Dutour

et al. 2012

Int. J. Osteoarchaeol.

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Osseous ankylosis of large joints that occurs secondary to infection is rarely described in developed countries, thanks to diagnostic techniques that allow early detection and treatment of the underlying infection. Evidence of the natural history and progression of the disease is now primarily studied through the observation and analysis of osteoarcheological specimens, and medical reports or books dating from the pre-antibiotic era. This report illustrates several cases where modern medical imaging techniques and ancient medical literature were successfully interpreted to diagnose rare, advanced-stage tuberculous alterations in osteoarcheological specimens. Two skeletons from the Bátmonostor cemetery (Hungary) demonstrate complete unilateral ankylosis of the knee. Macroscopic and radiographic examinations were undertaken to assess the extent of skeletal changes and determine their cause. Data obtained from computed tomography (CT) were constructed in 2D and 3D. The 2D CT images revealed cavities involving both the metaphyses and the epiphyses. The 3D reconstructions allowed us to reconstruct the more precise volumetric morphology of the circumscribed lytic lesions, as well as clear 'image-mirror' lacunar volumes. On the basis of the macroscopic and radiological analyses, extra-spinal tuberculous infection seems to have been the most probable etiology of these two cases.

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Tuberculosis of the Musculoskeletal System

Cited by 55 publications

References 74 publications

Insights on the paleoepidemiology of ancient tuberculosis from the structural analysis of postcranial remains from the Ligurian Neolithic (northwestern Italy)

Insights on the paleoepidemiology of ancient tuberculosis from the structural analysis of postcranial remains from the Ligurian Neolithic (northwestern Italy)

Correlation between Degree of Gibbus Angulation, Neurological Deficits, and Pain in Spondylitis Tuberculosis Patients

Knee Ankyloses Associated with Tuberculosis from the Medieval Hungary - Differential Diagnosis Based on Medical Imaging Techniques

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