Tuberculosis is frequently diagnosed within 12 months of diabetes mellitus

Heo, Eun Young; Choi, Nam-Kyong; Yang, Bong Min; Koo, Bo-Kyung; Hwang, Seung Sik; Lee, C. H.; Kang, Young Ae

doi:10.5588/ijtld.14.0772

Cited by 15 publications

(18 citation statements)

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“…Patients who took anti‐diabetic drugs at least once or with ICD‐10 codes for DM (E11‐E14) at least once between 1 January 2007 and 31 December 2008 were excluded. To identify new cases of TB, we excluded patients who took either anti‐TB drugs or with ICD‐10 codes for TB (A15‐A19, U88‐U88.1) before the diagnosis of DM . We excluded patients if the regions in which they were initially diagnosed with DM and TB were different.…”

Section: Methodsmentioning

confidence: 99%

“…However, to date, there has been no study investigating whether such risk factors are actually associated with the regional differences in the TB burden. In the present study, we applied a previously reported cohort of patients with newly diagnosed diabetes mellitus (DM), which is another important risk factor for the development of TB, as a means to analyse the relationship between several risk factors and regional differences in TB incidence.…”

Section: Introductionmentioning

confidence: 99%

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Regional differences in the incidence of tuberculosis among patients with newly diagnosed diabetes mellitus

Yang

Kang

Heo

et al. 2017

Clinical Respiratory J

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Regional differences in the incidence of tuberculosis among patients with newly diagnosed diabetes mellitus

Yang

Kang

Heo

et al. 2017

Clinical Respiratory J

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“…One interesting finding is that 7% of the people with DM reported prior TB history, and over 50% of prior TB was diagnosed before a DM diagnosis. Of these, 11% reported previous TB diagnosis within the first 2 years of DM diagnosis [22]. Screening for TB among people with DM is now strongly recommended in India [6, 23], though there is a need to identify specific factors among people with DM that increase risk of TB so that screening can be targeted and effective.…”

Section: Discussionmentioning

confidence: 99%

Tuberculosis screening among persons with diabetes mellitus in Pune, India

Mave

Nimkar

et al. 2017

BMC Infect Dis

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BackgroundDiabetes mellitus (DM) increases tuberculosis (TB) risk, and there is increasing concern over the public health implications of the convergence of these two epidemics. Screening for TB among people with DM is now recommended in India.MethodsPeople with DM seeking care at a large public sector tertiary care hospital clinic in Pune, India, were screened for TB from June 2015 to May 2016. All consenting people with DM were screened for TB at each clinic visit using a five-item, WHO-recommended questionnaire and those with TB symptoms and/or risk factors were tested for active TB using sputum smear microscopty, Xpert® MTB/RIF and TB culture. Categorical data and continuous variables were summarized using descriptive statistics. The x 2 test or Wilcoxon rank-sum test was used to ascertain significant associations between categorical and continuous variables, respectively.ResultsAmong 630 adults approached for screening, median age was 60 (interquartile range (IQR), 57–64) years and 350 (56%) were females. Median hemoglobin A1c (HbA1c) was 8.7% (IQR, 6.7–9.9) and 444 (70.5%) were poorly controlled DM (HbA1c > 7). Forty-four (7%) had prior history of TB but the proportion with TB risk factors at screening was low (<5%). While 18% of participants reported any TB symptoms, none of these patients were diagnosed with culture confirmed TB.ConclusionsOur study failed to yield any active TB cases using a WHO-recommended questionnaire among people with DM. High TB risk populations among people with DM must be identified if TB screening is to be feasible in settings such as India where the DM epidemic continues to rise.Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-017-2483-9) contains supplementary material, which is available to authorized users.

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“…2 As a matter of fact, the same group had previously observed that the incidence of TB infection occurred most frequently within the first year from DM diagnosis. 3 On the contrary, Lee et al had shown that the prevalence of diabetes was higher in patients with pulmonary tuberculosis compared to the general population. 4 Since this subject is of wide interest and continuously evolving, we would like to highlight some aspects.…”

Section: Dear Editormentioning

confidence: 96%