Tuberculosis in renal transplant patients: The experience of a single center in Medellín-Colombia, 2005-2013

Tuberculosis after kidney transplantation is associated with significantly impaired allograft function

“…In our cohort of KTRs, the demographics and clinical characteristics of TB disease were quite similar to those described by other transplant centers located in endemic regions, with late occurrence, high incidence of extrapulmonary and disseminated forms, difficulty in attaining a definitive diagnosis, and prolonged treatments . Studies performed in low‐incidence countries have demonstrated earlier clinical presentation .…”

Mycobacterium tuberculosisafter solid organ transplantation: A review of more than 2000 cases

“…During the period from 1998 to 2016, a total of 187 studies reported 2082 cases of TB after SOT. 2, The majority (135/187 [72.19%]) were case reports or series, while the remainder were retrospective studies (n = 43), 40,138,139,[141][142][143][144][145][146][147][148]150,[152][153][154][156][157][158][159][160][161][162]164,[166][167][168][169][170][173][174][175][176][179][180][181][182][183][184][185][186][187][188][189] case-control studies (n = 5), 140,163,171,172,…”

“…Twenty-nine studies [138][139][140]143,145,148,150,152,[154][155][156][158][159][160][165][166][167][168]170,173,174,[178][179][180][181][182][183]186,188 provided incidence of TB among kidney-only recipients, while 13 studies 141,142,146,149,157,161,164,171,172,184,185,187,189 Rejection prior to TB occurred in 184 of 531 (34.65%) cases. The use of CD4-depleting agents such as muromonab (OKT-3) or alemtuzumab (anti-CD52) was detailed in 13 of 38 (34.21%) case reports, 9,13,21,25,39,59,74,…”

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“…It is mostly related to the severity of TB and the complications of anti-TB therapy. 24,25 Mortality is higher when TB occurs during the first year after kidney transplant, among poor-nourished patients, those treated with steroids, and those with hypoxia. 26 …”