Tuberculosis in people living with human immunodeficiency virus might be overlooked

Jipa, Raluca; Cernat, Roxana Carmen; Dumitru, Irina Magdalena; Manea, Eliza; Resul, Ghiulendan; Hristea, Adriana

doi:10.4323/rjlm.2019.318

Cited by 1 publication

(2 citation statements)

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“… 8 A study among people with TB/HIV co-infection in Romania found that 30% of them had concurrent PTB and EPTB, suggesting that people with HIV may have a higher prevalence of concurrent PTB and EPTB. 9 …”

Section: Introductionmentioning

confidence: 99%

“…8 A study among people with TB/HIV coinfection in Romania found that 30% of them had concurrent PTB and EPTB, suggesting that people with HIV may have a higher prevalence of concurrent PTB and EPTB. 9 There is still scarcity of data on the characteristics and treatment outcomes of people with concurrent PTB and EPTB particularly in sub-Saharan Africa where the prevalence of HIV among TB cases is high (32%). 10 The purpose of this study, therefore, was to determine the prevalence, associated factors, and treatment outcomes of concurrent PTB and EPTB among people with TB at a national TB treatment center in Uganda.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The prevalence of concurrent pulmonary and extrapulmonary tuberculosis in Uganda: a retrospective study

Kyagulanyi

Mirembe

Nantaayi

et al. 2022

Therapeutic Advances in Infection

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Background: Concurrent pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) is associated with poor treatment outcomes yet its epidemiology in Uganda is unknown. The purpose of this study was to determine the prevalence, associated factors, and treatment outcomes of concurrent PTB and EPTB among patients at a national tuberculosis (TB) treatment center located at Mulago National Referral Hospital in Kampala, Uganda. Methods: We conducted a retrospective review of charts for people with TB who were enrolled in care between January 2015 and December 2019. Eligible charts were for people with pulmonary bacteriologically confirmed TB enrolled into care in the period under study. Concurrent PTB and EPTB was defined as PTB and bacteriological, histopathological, and/or radiological features of TB at another noncontiguous sites. Results: Overall, 400 patient charts were eligible, of whom 240 (60.0%) were aged 15–34 years and 205 (51.3%) were female. The prevalence of concurrent PTB and EPTB was 8.5% (34/400) [95% confidence interval (CI): 6.0–11.7%]. People with concurrent PTB and EPTB were more likely to have at least one comorbidity (82.4% versus 37.2%, p < 0.001), of which HIV was the most frequent. Furthermore, people with concurrent PTB and EPTB were more likely to have empyema (15% versus 2.6%, p = 0.028) but less likely to have bronchopneumonic opacification (0.0% versus 15.3%, p = 0.043) on chest x-ray imaging. People with concurrent PTB and EPTB had higher mortality (26.5% versus 6.37%) and a lower cure rate (41.2% versus 64.8%), p = 0.002. Conclusion: Our findings highlight the need for early detection of TB before dissemination particularly among people who use alcohol and people with HIV.

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Section: Introductionmentioning

confidence: 99%