Tuberculosis in animals and humans

Thoen, Charles O.; LoBue, Philip; Enarson, Donald A.

doi:10.1002/9781118474310.ch1

Cited by 86 publications

(120 citation statements)

References 13 publications

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“…Nevertheless, due to the limitations of all those methods, the deϐinitive diagnosis that a herd is infected requires a clear evidence of the agent, based on bacteriological culture, histopathology (HP) or molecular methods (Thoen et al 2009. The histopathology of lesions, in addition of being a diagnostic tool, also provides information on the immune responses of the host .…”

Section: Introductionmentioning

confidence: 99%

Assessing the histopathology to depict the different stages of bovine tuberculosis infection in a naturally infected herd

et al. 2012

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The standard method for detection of bovine tuberculosis (TB) is the single intradermal tuberculin test (SITT). Nevertheless, current studies suggest that a single test is not enough to detect all cattle infected by TB, particularly when animals present different stages of infection. A dairy herd comprised of 270 cows was studied and 15 were reactive to SITT plus nine inconclusive animals. Blood samples (for IFN and ELISA) were collected from these 24 cows. At 30 days after injection of PPD, all the cows that were reactive to any of the employed tests were slaughtered, and tissues were processed by Bacteriology, Histopathology (HP) and PCR. According to HP 33.4% of the animals were positive, 45.8% inconclusive and 20.8% were negative. The inconclusive samples came from IFN positive animals, signalizing recent infection. Regarding the animals that were negative to HP, all of them were identiϐied by IFN while ELISA was negative. Immune responses are different in recent and advanced infections, what supports the identiϐication between chronically or recently infected animals. This multidisciplinary approach is mandatory for the interpretation of the various tools that are frequently employed for the diagnosis of TB and mainly to identify all infected animals.INDEX TERMS: Bovine tuberculosis, diagnosis, multidisciplinary approach, histopathology.

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Section: Introductionmentioning

confidence: 99%

Assessing the histopathology to depict the different stages of bovine tuberculosis infection in a naturally infected herd

et al. 2012

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“…However, previous reports of clusters of cases with social links and molecular epidemiology and evidence from surveys of contact subjects from M. bovis pulmonary tuberculosis patients suggested that inter-human transmission occurs even in non-immunocompromised individuals. Several cases of inter-human transmission of tuberculosis to M. bovis was well documented [28][29][30][31][32].…”

Section: Figurementioning

confidence: 99%

Mycobacterium bovis Prevalence in Humans Does Not Differ between Regions in Burkina Faso

Diagbouga¹,

Nadembèga²,

Tarnagda³

et al. 2017

Arch Clin Microbiol

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“…Bovine tuberculosis, caused by Mycobacterium bovis, is a reemerging disease that affects wildlife, livestock, and humans (Thoen et al 2009). It is endemic in free-ranging wood bison (Bison bison athabascae) populations in and around Wood Buffalo National Park (WBNP), Canada (Joly and Messier 2004), and these populations act as a reservoir of the pathogen (Nishi et al 2006).…”

Section: Introductionmentioning

confidence: 99%

BAYESIAN ANALYSIS TO EVALUATE TESTS FOR THE DETECTION OF MYCOBACTERIUM BOVIS INFECTION IN FREE-RANGING WILD BISON (BISON BISON ATHABASCAE) IN THE ABSENCE OF A GOLD STANDARD

Chapinal

Schumaker

Joly³

et al. 2015

Journal of Wildlife Diseases

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ABSTRACT:We estimated the sensitivity and specificity of the caudal-fold skin test (CFT), the fluorescent polarization assay (FPA), and the rapid lateral-flow test (RT) for the detection of Mycobacterium bovis in free-ranging wild wood bison (Bison bison athabascae), in the absence of a gold standard, by using Bayesian analysis, and then used those estimates to forecast the performance of a pairwise combination of tests in parallel. In 1998-99, 212 wood bison from Wood Buffalo National Park (Canada) were tested for M. bovis infection using CFT and two serologic tests (FPA and RT). The sensitivity and specificity of each test were estimated using a three-test, one-population, Bayesian model allowing for conditional dependence between FPA and RT. The sensitivity and specificity of the combination of CFT and each serologic test in parallel were calculated assuming conditional independence. The test performance estimates were influenced by the prior values chosen. However, the rank of tests and combinations of tests based on those estimates remained constant. The CFT was the most sensitive test and the FPA was the least sensitive, whereas RT was the most specific test and CFT was the least specific. In conclusion, given the fact that gold standards for the detection of M. bovis are imperfect and difficult to obtain in the field, Bayesian analysis holds promise as a tool to rank tests and combinations of tests based on their performance. Combining a skin test with an animal-side serologic test, such as RT, increases sensitivity in the detection of M. bovis and is a good approach to enhance disease eradication or control in wild bison.

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Tuberculosis in animals and humans

Cited by 86 publications

References 13 publications

Assessing the histopathology to depict the different stages of bovine tuberculosis infection in a naturally infected herd

Assessing the histopathology to depict the different stages of bovine tuberculosis infection in a naturally infected herd

Mycobacterium bovis Prevalence in Humans Does Not Differ between Regions in Burkina Faso

BAYESIAN ANALYSIS TO EVALUATE TESTS FOR THE DETECTION OF MYCOBACTERIUM BOVIS INFECTION IN FREE-RANGING WILD BISON (BISON BISON ATHABASCAE) IN THE ABSENCE OF A GOLD STANDARD

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