Tuberculosis in adult patients with sickle cell disease

Lionnet, François; Bachmeyer, Claude; Sloma, Ivan; Rossier, Anne; Thiolière, Brigitte; Maier, Micheline; Grateau, Gilles; Girot, Robert; Cadranel, Jacques

doi:10.1016/j.jinf.2007.07.001

Cited by 11 publications

(5 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To our knowledge there are no studies addressing TB susceptibility in malaria-infected individuals, although interestingly placental malaria has been associated with an attenuated immune response to BCG vaccination at birth64. There is one report of significantly increased rates of lymph node TB but reduced rates of pulmonary TB in patients with sickle cell disease65. Boelaert et al .…”

Section: Discussionmentioning

confidence: 99%

The influence of haemoglobin and iron on in vitro mycobacterial growth inhibition assays

Tanner

O’Shea

White

et al. 2017

Sci Rep

View full text Add to dashboard Cite

The current vaccine against tuberculosis, live attenuated Mycobacterium bovis BCG, has variable efficacy, but development of an effective alternative is severely hampered by the lack of an immune correlate of protection. There has been a recent resurgence of interest in functional in vitro mycobacterial growth inhibition assays (MGIAs), which provide a measure of a range of different immune mechanisms and their interactions. We identified a positive correlation between mean corpuscular haemoglobin and in vitro growth of BCG in whole blood from healthy UK human volunteers. Mycobacterial growth in peripheral blood mononuclear cells (PBMC) from both humans and macaques was increased following the experimental addition of haemoglobin (Hb) or ferric iron, and reduced following addition of the iron chelator deferoxamine (DFO). Expression of Hb genes correlated positively with mycobacterial growth in whole blood from UK/Asian adults and, to a lesser extent, in PBMC from South African infants. Taken together our data indicate an association between Hb/iron levels and BCG growth in vitro, which may in part explain differences in findings between whole blood and PBMC MGIAs and should be considered when using such assays.

show abstract

Section: Discussionmentioning

confidence: 99%

The influence of haemoglobin and iron on in vitro mycobacterial growth inhibition assays

Tanner

O’Shea

White

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Functional asplenia is not a well-documented risk factor for tB. 22 However, given the high rate of tB in many african-american communities, 23 screening children with hemoglobinopathies for tB is not unreasonable.…”

Section: Discussionmentioning

confidence: 99%

Adolescents With Tuberculosis

Cruz

Hwang

Birnbaum

et al. 2013

Pediatric Infectious Disease Journal

View full text Add to dashboard Cite

show abstract

“…Interestingly, they also noted that pulmonary tuberculosis in SCD was less frequent than expected. [39]…”

Section: Other Travel-associated Infectionsmentioning

confidence: 99%

Travelers With Sickle Cell Disease

2014

View full text Add to dashboard Cite

Background Sickle cell disease (SCD) is the most common genetic disease among persons with African ancestry. This article provides a background on SCD and reviews many important aspects of travel preparation in this population. Methods The medical literature was searched for studies about travel-associated preparedness and complications in individuals with SCD. Topics researched included malaria, bacterial infections, vaccinations, dehydration, altitude, air travel, and travel preparedness. Results There is very little published literature that specifically addresses the risks faced by travelers with SCD. Rates of medical complications during travel appear to be high. There is a body of literature that describes complications of SCD in indigenous populations, particularly within Africa. The generalizability of these data to a traveler are uncertain. Combining these sources of data and the broader medical literature we address major travel-related questions that may face a provider preparing an individual with SCD for safe travel. Conclusions Travelers with SCD face considerable medical risks when traveling to developing tropical countries; these include malaria, bacterial infections, hypovolemia, and sickle cell-associated vaso-occlusive crises. Frank counseling about risks, vigilant preventative measures, and contingency planning for illness while abroad are necessary parts of the pre-travel visit for individuals with SCD.

show abstract

Tuberculosis in adult patients with sickle cell disease

Cited by 11 publications

References 19 publications

The influence of haemoglobin and iron on in vitro mycobacterial growth inhibition assays

The influence of haemoglobin and iron on in vitro mycobacterial growth inhibition assays

Adolescents With Tuberculosis

Travelers With Sickle Cell Disease

Contact Info

Product

Resources

About