Tuberculosis Genetic Epidemiology: A Latin American Perspective

Woodman, Marc; Haeusler, Ilsa L.; Grandjean, Louis

doi:10.3390/genes10010053

Cited by 38 publications

(46 citation statements)

References 126 publications

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“…As a second aim we described for the first time, the molecular epidemiology of tuberculosis in Guatemala. The most common spoligotypes families found in this study, LAM, T and Haarlem are similar to the ones obtained in South America, although their proportion varied according to the country as recently reviewed [32, 33]. Nevertheless, the X family accounted for less than 7% in the majority of these studies and we found a prevalence of 13%.…”

Section: Discussionsupporting

confidence: 89%

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Characterization of the Proportion of Clustered Tuberculosis Cases in Guatemala, Ca: Insights From a Molecular Epidemiology Study, 2010-2014

Castellanos

Lau-Bonilla

Möller

et al. 2020

Preprint

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Background. There is little information about the proportion of clustering of tuberculosis cases from low-income settings, which can represent ongoing transmission events. Objectives. We investigated the proportion of clustered tuberculosis cases based on genotypic matching in Guatemala and potential factors associated with clustering in HIV-infected subjects. Moreover, the genetic diversity of Mycobacterium tuberculosis isolates in this country is presented. Methods. We performed an observational study on M. tuberculosis isolates from tuberculosis cases that submitted samples to a referral laboratory in Guatemala City, Guatemala (2010-2014). Genotyping results were classified according to the international spoligotyping database. We estimated the proportion of clustering and the recent transmission index (RTIn-1). We analyzed the association between clinical and behavioral variables and clustering in the HIV-population. Findings. Spoligotype patterns were available from 391 patients out of 479 confirmed cases (82%). The most frequent spoligotyping families were LAM (39%), T (22%) and Haarlem (14%). The proportion of clustering was 91% and the RTIn-1 was 82%. Clustered isolates grouped in 36 clusters (range: 2-92). Pulmonary tuberculosis was associated with clustering in the HIV-infected group (OR=4.3, 95% CI 1.0-17.7). Conclusion. There might be high levels of ongoing transmission of M. tuberculosis in Guatemala as indicated by clustering in a convenience sample.

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Section: Discussionsupporting

confidence: 89%

“…Lineage 4 is one of the seven lineages in which are categorized M. tuberculosis complex strains and is the one with the largest distribution in the world [35, 36]. Its introduction in the Americas is considered to be owed to the European colonization of the continent after the 1500s [33].…”

Section: Discussionmentioning

confidence: 99%

Characterization of the Proportion of Clustered Tuberculosis Cases in Guatemala, Ca: Insights From a Molecular Epidemiology Study, 2010-2014

Castellanos

Lau-Bonilla

Möller

et al. 2020

Preprint

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“…In addition, the transmission of MTB depends on its ability to damage lung tissues to a large extent. 25 Consequently, DR-MTB with substantial lung tissue damage is likely to cause the extensive spread of TB lesions.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of Chest Computed Tomography Findings: 1030 Cases of Drug-Sensitive Tuberculosis versus 516 Cases of Drug-Resistant Tuberculosis

Cheng¹,

Wu²,

Luo³

et al. 2021

IDR

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Purpose: To investigate the CT features of drug-resistant pulmonary tuberculosis (DR-PTB) and the diagnostic value of CT in DR-PTB diagnosis to provide imaging evidence for the timely detection of drug-resistant Mycobacterium tuberculosis. Materials and Methods: A total of 1546 cases of pulmonary tuberculosis (PTB) with complete clinical data, chest CT images and defined drug sensitivity testing results were consecutively enrolled; 516 cases of DR-PTB were included in the drug-resistant group, and 1030 cases of drug-sensitive pulmonary tuberculosis (DS-PTB) were included in the drugsensitivity group. Comparative analyses of clinical symptoms and imaging findings were conducted. Univariate and logistic regression analyses were performed, a regression equation model was developed, and the receiver operating characteristic (ROC) curve was constructed. Results: In the univariate analysis, some features, including whole-lung involvement, multiple cavities, thick-walled cavities, collapsed lung, disseminated lesions along the bronchi, bronchiectasis, emphysema, atelectasis, calcification, proliferative lesions, encapsulated effusion, etc., were observed more frequently in the DR-PTB group than in the DS-PTB group, and the differences were statistically significant (p<0.05). Exudative lesions and pneumoconiosis were observed more frequently in the drug-sensitivity group than in the drug-resistant group (p<0.05). Logistic regression analysis indicated that whole-lung involvement, multiple cavities, thick-walled cavities, disseminated lesions along the bronchi, bronchiectasis, and emphysema were independent risk factors for DR-PTB, and exudative diseases were protective factors. The total prediction accuracy of the regression model was 80.6%, and the area under the ROC curve (AUC) was 82.6%. Conclusion: Chest CT manifestations of DR-PTB had certain characteristics that significantly indicated the possibility of drug resistance in tuberculosis patients, specifically when multifarious imaging findings, including multiple cavities, thick-walled cavities, disseminated lesions along the bronchi, whole-lung involvement, etc., coexisted simultaneously. These results may provide imaging evidence for timely drug resistance detection in suspected drug-resistant cases and contribute to the early diagnosis of DR-PTB.

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“…Regarding the lineages, the Brazilian profile observed in this demonstrate the higher frequency of Lineage 4, mainly LAM genotype and the higher frequency of Lineage 1 in Pará State. 130 , 131 , 132 , 133 The presence of M. tuberculosis var. bovis among human strains was not reported so far, and M. tuberculosis var.…”

Section: Discussionmentioning

confidence: 99%

Molecular epidemiology of Mycobacterium tuberculosis in Brazil before the whole genome sequencing era: a literature review

Conceição

Salvato

Gomes

et al. 2021

Mem. Inst. Oswaldo Cruz

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Molecular-typing can help in unraveling epidemiological scenarios and improvement for disease control strategies. A literature review of Mycobacterium tuberculosis transmission in Brazil through genotyping on 56 studies published from 1996-2019 was performed. The clustering rate for mycobacterial interspersed repetitive units - variable tandem repeats (MIRU-VNTR) of 1,613 isolates were: 73%, 33% and 28% based on 12, 15 and 24-loci, respectively; while for RFLP-IS 6110 were: 84% among prison population in Rio de Janeiro, 69% among multidrug-resistant isolates in Rio Grande do Sul, and 56.2% in general population in São Paulo. These findings could improve tuberculosis (TB) surveillance and set up a solid basis to build a database of Mycobacterium genomes.

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Tuberculosis Genetic Epidemiology: A Latin American Perspective

Cited by 38 publications

References 126 publications

Characterization of the Proportion of Clustered Tuberculosis Cases in Guatemala, Ca: Insights From a Molecular Epidemiology Study, 2010-2014

Characterization of the Proportion of Clustered Tuberculosis Cases in Guatemala, Ca: Insights From a Molecular Epidemiology Study, 2010-2014

A Comparative Study of Chest Computed Tomography Findings: 1030 Cases of Drug-Sensitive Tuberculosis versus 516 Cases of Drug-Resistant Tuberculosis

Molecular epidemiology of Mycobacterium tuberculosis in Brazil before the whole genome sequencing era: a literature review

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