Tuberculosis due to Mycobacterium bovis and Mycobacterium caprae in sheep

Mendoza, Marta Muñoz; Juan, Lucía de; Menéndez, S.; Ocampo, Antón; Mourelo, Jorge; Sáez, José Luis; Domı́nguez, Lucas; Gortázar, Christian; Marı́n, Juan Francisco Garcı́a; Balseiro, Ana

doi:10.1016/j.tvjl.2011.05.006

Cited by 43 publications

(33 citation statements)

References 10 publications

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“…Histopathology was typical of mycobacterial infection, but there was a distinct paucity of acid-fast bacteria seen on ZN-stained sections. This finding concurs with findings by others (Cordes and others 1981, Davidson and others 1981, Malone and others 2003, Marianelli and others 2010, Muñoz-Mendoza and others 2011). ZN smears of fresh tissues did not reveal any acid-fast organisms either.…”

Section: Discussionsupporting

confidence: 94%

“…Single cases (Houlihan and others 2008, Marianelli and others 2010) and flock outbreaks (Cordes and others 1981, Davidson and others 1981, Malone and others 2003, Muñoz Mendoza and others 2011) have been reported. M bovis infection was typically detected by the recognition of suspicious lesions at slaughter or at a diagnostic postmortem examination where the lesions have often been incidental findings (Cordes and others 1981, Houlihan and others 2008, Marianelli and others 2010, Muñoz Mendoza and others 2011, Tag el Din and others 1982). In two outbreaks, infected sheep were detected after skin testing of sheep in contact with tuberculous cattle (Davidson and others 1981, Malone and others 2003).…”

Section: Introductionmentioning

confidence: 99%

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An outbreak of tuberculosis in Lleyn sheep in the UK associated with clinical signs

Burgt¹,

Drummond²,

Crawshaw³

et al. 2013

Vet Record Case Reports

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This case report describes an outbreak of Mycobacterium bovis infection a Lleyn sheep flock associated with clinical signs of illthrift. There was no known direct contact with tuberculous cattle although bovine tuberculosis (bTB) is endemic in the area. The spoligotype isolated from the diseased sheep was the local spoligotype. The repeated use of the comparative intradermal tuberculin test, and the subsequent removal of reactor animals, resulted in apparent elimination of bTB from the flock. Lesions caused by M bovis in sheep may contain very few acid-fast bacilli, and gross lesions may resemble those found in cases of Caseous Lymphadenitis. Routine meat inspection may, therefore, not always easily detect this notifiable disease.

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

An outbreak of tuberculosis in Lleyn sheep in the UK associated with clinical signs

Burgt¹,

Drummond²,

Crawshaw³

et al. 2013

Vet Record Case Reports

View full text Add to dashboard Cite

show abstract

“…As explained by different reports, including Radostits et al [36], as age increases the probability of acquiring TB infection increases. The result was in agreement with previous studies where sheep TB has been reported [35,[37][38][39]. Furthermore, in the multivariable logistic regression analysis, statistically significant difference was observed between goats and sheep.…”

Section: Discussionsupporting

confidence: 93%

Epidemiology and Molecular Characterization of Causative Agents of Bovine Tuberculosis in Ruminants

Ashenafi¹

2012

J Bacteriol Parasitol

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A cross sectional study was conducted on 110 cattle and 397 small ruminants to determine the prevalence of bovine tuberculosis and possible risk factors, and to characterize the species of Mycobacteria circulating in Chifra district. Bacterial isolation and multiplex Polymerase Chain Reaction (PCR) were performed on milk and nasal swab samples of reactor animals. In tuberculin test, 13.64% cattle and 5.29% small ruminants were positive, and 31.58% and 25.00% were positive cultures on Löwenstein-Jensen media from milk and nasal swab samples, respectively. Based on PCR products, 12 were positive for genus Mycobacterium and none were positive for Mycobacterium tuberculosis complex or Mycobacterium avium-intracellulare complex group. The reactor rates observed for cattle under different body condition scores were poor (17.24%), medium (6.25%) and good (50.00%) Body Condition Scores (BCS) (P=0.025). The stepwise logistic regression analysis using independent variable medium BCS as a reference category indicated that good BCS (adjusted OR=4.29, 95% CI for OR=0.49-37.89) significantly affected tuberculin reactivity. This study showed that the prevalence of Single Comparative Intra-dermal Tuberculin (SCIDT) test positives and risk of acquiring the disease, increased with good BCS. Thus, more sensitive diagnostic techniques and control strategies should be considered on this risk group.

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“…Moreover, in these areas there are reports of Iberian pigs infected with M. bovis with generalized lesions [54]. Reports of tuberculosis in sheep have been described in Italy [55] United Kingdom [56] and Spain [57] suggesting their potential to act as a reservoir for tuberculosis. The lack of data from these domestic species, together with the uncertainty regarding their role in bTB epidemiology in Spain made not possible to include them in the analysis.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Investigation of Bovine Tuberculosis Herd Breakdowns in Spain 2009/2011

et al. 2014

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We analyzed the most likely cause of 687 bovine tuberculosis (bTB) breakdowns detected in Spain between 2009 and 2011 (i.e., 22% of the total number of breakdowns detected during this period). Seven possible causes were considered: i) residual infection; ii) introduction of infected cattle from other herds; iii) sharing of pastures with infected herds; iv) contiguous spread from infected neighbor herds; v) presence of infected goats in the farm; vi) interaction with wildlife reservoirs and vii) contact with an infected human. For each possible cause a decision tree was developed and key questions were included in each of them. Answers to these key questions lead to different events within each decision tree. In order to assess the likelihood of occurrence of the different events a qualitative risk assessment approach was used. For this purpose, an expert opinion workshop was organized and ordinal values, ranging from 0 to 9 (i.e., null to very high likelihood of occurrence) were assigned. The analysis identified residual infection as the most frequent cause of bTB breakdowns (22.3%; 95%CI: 19.4–25.6), followed by interaction with wildlife reservoirs (13.1%; 95%CI: 10.8–15.8). The introduction of infected cattle, sharing of pastures and contiguous spread from infected neighbour herds were also identified as relevant causes. In 41.6% (95%CI: 38.0–45.4) of the breakdowns the origin of infection remained unknown.Veterinary officers conducting bTB breakdown investigations have to state their opinion about the possible cause of each breakdown. Comparison between the results of our analysis and the opinion from veterinary officers revealed a slight concordance. This slight agreement might reflect a lack of harmonized criteria to assess the most likely cause of bTB breakdowns as well as different perceptions about the importance of the possible causes. This is especially relevant in the case of the role of wildlife reservoirs.

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Tuberculosis due to Mycobacterium bovis and Mycobacterium caprae in sheep

Cited by 43 publications

References 10 publications

An outbreak of tuberculosis in Lleyn sheep in the UK associated with clinical signs

An outbreak of tuberculosis in Lleyn sheep in the UK associated with clinical signs

Epidemiology and Molecular Characterization of Causative Agents of Bovine Tuberculosis in Ruminants

Epidemiological Investigation of Bovine Tuberculosis Herd Breakdowns in Spain 2009/2011

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