Tuberculosis: Disease of the past, disease of the present

Griffith, David E.; Kerr, Clark M.

doi:10.1016/s1089-9472(96)80023-2

Cited by 32 publications

(13 citation statements)

References 6 publications

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“…Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis that has historically been known to be influenced by undernutrition. It is the major cause of morbidity and mortality in developing countries where malnutrition is also prevalent [6]. It is also well established that the cellular immune response, whose efficacy is compromised during undernutrition, is required to protect against TB.…”

Section: Introductionmentioning

confidence: 99%

Is the BCG Vaccine Safe for Undernourished Individuals?

Ishikawa

Rosa

França

et al. 2012

Clinical and Developmental Immunology

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Cellular immunity is critical for protection against tuberculosis, but its integrity is compromised during undernutrition. The present study was designed to evaluate if the attenuated mycobacterium BCG is a safe vaccine for undernourished individuals. An experimental model of undernutrition was established by subjecting BALB/c mice to dietary restriction. These animals received 70% of the amount of food consumed by the healthy control group and exhibited physiological alterations compatible with malnutrition, including body weight loss, reduced levels of triglycerides and glucose, and reduced lymphocyte numbers. Undernourished mice were immunized with BCG, and the mycobacterial loads in lymph nodes, spleen, liver, lungs, and thymus were determined. A much higher proportion of undernourished mice exhibited bacterial dissemination to the lymph nodes, spleen and liver. In addition, only undernourished animals had bacteria in the lungs and thymus. Concomitant with higher mycobacterial loads and more widespread BCG dissemination in undernourished mice, production of TNF-α, IFN-γ, and IL-10 was also diminished in these mice. Taken together, these results indicate that BCG infection is more severe in undernourished mice. Whether a similar phenomenon exists in undernourished children or not remains to be thoroughly investigated.

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Section: Introductionmentioning

confidence: 99%

Is the BCG Vaccine Safe for Undernourished Individuals?

Ishikawa

Rosa

França

et al. 2012

Clinical and Developmental Immunology

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“…Kelenjar limfe yang sering terlibat adalah pada area posterior, anterior, dan supraclavicula dari rantai kelenjar limfe pada leher, namun dapat pula mengenai kelenjar limfe lain yang tidak termasuk rantai kelenjar limfe leher. 11,12 Diagnosis pasti ditegakkan apabila pada pemeriksaan biopsi kelenjar limfe yang terkena didapatkan adanya gambaran granuloma kaseosa dan pada pengecatan jaringan didapatkan adanya BTA. 12 Pada kasus ini dari hasil anamnesis dan pemeriksaan fisik didapatkan adanya benjolan pada kelenjar supraclavicula sinistra yang dalam perjalanannya membaik dengan pemberian terapi OAT Kategori I yang ditambahkan dengan injeksi streptomicin intramuskuler selama 2 minggu.…”

Section: Diskusiunclassified

Seorang Wanita Dengan Tb Paru Kasus Baru Dan Tb Ekstra Paru Multiple

Atmanto

Maranatha

2019

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Background; Tuberculosis (TB) is a contagious disease caused by Mycobacterium tuberculosis (Acid-Fast Bacilli/AFB) that still be a world burden. Extra Pulmonary TB occurred when there were infection and development of Mycobacterium tuberculosis outside lungs, which about 10% cases was Milliary TB. There will be reported case with Lung TB New Case coexistence with Multiple Extra Pulmonary TB. Case; A female, 39 y.o., came to the Soetomo General Teaching Hospital with chief complaint body weakness since 12 months ago following with cough, decrease of appetite, decrease of body weight, low grade fever, and night sweating. The cough was on and off, not productive, and didn`t improve with usual therapy. Her other complaint were painless mass at the left supraclavicular area, swollen and pain at the right knee, and pain at the backbones. Patient had subsequently given Anti Tuberculosis Drugs (ATD) with Streptomycin injection based on clinical judgement. Discussion; In several cases, Primary Focus as the result of AFB infection in the lung can spread to the other organs. The diagnosis had been made from comprehensive summary of clinical aspects, radiology data, laboratory data, and Histopathology data. Consideration of ATD choice based on grouping of TB diseases (Pulmonary/Extra Pulmonary), severity level of Extra Pulmonary TB and clinical judgement Conclusion; Had reported female patient diagnosed with Lung TB New Case, Osteomyelitis TB, Spondilitis TB, and Lymphadenitis TB. Based on therapeutic evaluation there was improvement condition of the patient after administration of ATD and injection of Streptomycin.

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“…prisons and homeless shelters), medically underprivileged and resource-poor communities, high-risk ethnic minorities, children in close contact with high-risk category patients, and health-care providers serving these patients (Griffith and Kerr, 1996).Other disease states can also increase the risk of developing tuberculosis. These include alcoholism (Lawn and Zumla, 2011) and diabetes mellitus (Restrepo 2007).Certain medications, such as corticosteroids and infliximab are becoming increasingly important risk…”

Section: Article May Be Cited Asmentioning

confidence: 99%

Risk Factors of Multidrug-Resistant Tuberculosis

Rumende

2017

Int J Appl Sci Biotechnol

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Multidrug-resistant tuberculosis has been increased worldwide which is a severe problem. A case-control study was carried out among 50 MDR-TB cases and 63 drug susceptible controls to identify risk factors associated with multidrug-resistant tuberculosis (MDR-TB) in Lumbini Zone. Irregularity in taking medicine (OR=2.36), large family size (OR=2.40), farming as occupation (OR=2.83), history of TB and bovine at home (OR=6.5) were statistically associated with MDR-TB. Most of the MDR-TB cases were males (82%) and individual with the age group 21-30 years (40%) were highly infected with MDR-TB.

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Tuberculosis: Disease of the past, disease of the present

Cited by 32 publications

References 6 publications

Is the BCG Vaccine Safe for Undernourished Individuals?

Is the BCG Vaccine Safe for Undernourished Individuals?

Seorang Wanita Dengan Tb Paru Kasus Baru Dan Tb Ekstra Paru Multiple

Risk Factors of Multidrug-Resistant Tuberculosis

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