Tuberculosis con resistencia a fármacos: nuevas definiciones de la OMS y su implicación en la Normativa de SEPAR

Caminero, José A.; García-García, José-María; Caylà, Joan A.; García-Pérez, Francisco J.; Palacios, Juan José; Ruiz-Manzano, Juan

doi:10.1016/j.arbres.2021.03.001

Cited by 3 publications

(1 citation statement)

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“…The aim of WHO's "End TB Strategy" for achieving a TB-free world requires global actions, joint efforts from different stakeholders, social and political commitment, and public and private investment. The emergence of Mtb-resistant strains reflects the mismanagement of TB, and its surveillance represents a challenge for TB operations around the world, especially in developing and under-resourced countries, as well as in countries with a prevalence of HIV/AIDS [101]. In this scenario, the importance of co-infections should also be considered; WHO's Global Tuberculosis Report [1] exhibited the damaging effect of the COVID-19 pandemic on TB diagnosis, treatment, and burden.…”

Section: Final Remarksmentioning

confidence: 99%

New Alternatives in the Fight against Tuberculosis: Possible Targets for Resistant Mycobacteria

Rodríguez-Bustamante,

Gómez-Manzo,

De Obeso Fernández del Valle

et al. 2023

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Tuberculosis (TB) is a bacterial disease that remains a global health threat due to the millions of deaths attributed to it each year. The emergence of drug resistance has exacerbated and further increased the challenges in the fight against this illness. Despite the preventive measures using the application of the Bacillus Calmette-Guérin vaccine, the desired immunization outcome is not as high as expected. Conventional TB treatments exhibit serious limitations, such as adverse effects and prolonged duration, leading to a pressing need for alternative and more effective treatment options. Despite significant efforts, it took nearly four decades for diarylquinoline to become the most recently approved medicine for this disease. In addition, various possibilities, such as the usage of medications used for many other conditions (repurposed drugs), have been explored in order to speed up the process of achieving faster outcomes. Natural compounds derived from various sources (microorganisms, plants, and animals) have emerged as potential candidates for combating TB due to their chemical diversity and their unique modes of action. Finally, efforts towards the generation of novel vaccines have received considerable attention. The goal of this paper was to perform an analysis of the current state of treating drug-resistant TB and to evaluate possible approaches to this complicated challenge. Our focus is centered on highlighting new alternatives that can be used to combat resistant strains, which have potentiated the health crisis that TB represents.

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Section: Final Remarksmentioning

confidence: 99%