Tuberculosis as a Trigger of Retroperitoneal Fibrosis

Background/Aims: Retroperitoneal fibrosis (RPF) is a chronic inflammatory disorder causing obstructive nephropathy and renal failure. We reviewed our management of this condition. Method: All patients with RPF treated at a single center over a 15-year period were identified. A full review of notes and computer records was undertaken. Results: Data was available on 27 patients, 3 of which were excluded from later analysis. Diagnosis was based on clinical history and cross-sectional imaging. Retroperitoneal biopsy was undertaken in 3 patients. 96% had significant renal impairment at presentation with a mean serum creatinine of 688 µmol/l. 46% required emergency hemodialysis. All patients were treated with a combination of ureteric stents and/or steroids with an excellent clinical response. The mean best creatinine reached by the cohort was 136 µmol/l, and renal function remained stable in the long term. No patients required chronic dialysis. Ureteric stents were removed within 12 months and low-dose steroids were continued for a mean of 34 months. Recurrent disease was observed in 25% of patients, who all responded well to further steroid therapy. Mean duration of follow-up was 76 months. Conclusions: RPF is very effectively treated by a combination of ureteric stents and steroids, with excellent long-term results using this approach. Continued follow-up is advised because of the possibility of recurrent disease.

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“…methyldopa), overt autoimmune disease and chronic infection (e.g. tuberculosis) [1, 6, 7]. There is also a link with asbestos exposure [8].…”

Section: Introductionmentioning

confidence: 99%

Successful Use of Steroids and Ureteric Stents in 24 Patients with Idiopathic Retroperitoneal Fibrosis: A Retrospective Study

et al. 2008

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“…[2][3][4][5][6][7][8] Retroperitoneal fibrosis may resemble, or occur in conjunction with, malignant tumors. Histological findings of biopsy specimens may sometimes not be specific for retroperitoneal fibrosis.…”

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confidence: 99%

18F-Fluorodeoxyglucose Positron Emission Tomography in a Case of Retroperitoneal Fibrosis

et al. 2006

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SUMMARYA patient with recurrent abdominal pain was admitted to our hospital. Computed tomography showed a soft dense mass surrounding the abdominal aorta at the infrarenal level, which was compatible with retroperitoneal fibrosis. F-FDG into these lesions. Two months after the initiation of corticosteroid therapy, the abnormal uptake of 18 F-FDG had ceased along with a reduction in the fibrous mass surrounding the abdominal aorta. (Int Heart J 2006; 47: 645-650)

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“…Radiation therapy [3] has been found to be a significant risk factor associated with RPF. Certain infections like tuberculosis [12] actinomycosis [13] and schisostomiasis [14] have been reported as causative factors of RPF. Previous trauma in form of surgery has also been reported [15].…”

Section: Discussionmentioning

confidence: 99%

Deep Vein Thrombosis /Pulmonary Embolism in a Patient with Retroperitoneal Fibrosis: A Case Report

Agrawal¹

2012

J Clin Case Rep

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Introduction: Retroperitoneal Fibrosis (RPF) is a clinicopathological condition characterized by inflammatory fibrotic reaction around infrarenal aorta, iliac vessels and surrounding retroperitoneum with myriad presentations. This case report shows how a Deep Vein Thrombosis (DVT) and subsequent Pulmonary Embolism (PE) can be a potential complication of this disease. A potential temporal association was seen with chronic beta blocker use and retroperitoneal fibrosis.

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Tuberculosis as a Trigger of Retroperitoneal Fibrosis

Cited by 34 publications

References 10 publications

Successful Use of Steroids and Ureteric Stents in 24 Patients with Idiopathic Retroperitoneal Fibrosis: A Retrospective Study

Successful Use of Steroids and Ureteric Stents in 24 Patients with Idiopathic Retroperitoneal Fibrosis: A Retrospective Study

18F-Fluorodeoxyglucose Positron Emission Tomography in a Case of Retroperitoneal Fibrosis

Deep Vein Thrombosis /Pulmonary Embolism in a Patient with Retroperitoneal Fibrosis: A Case Report

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