Tuberculosis as a risk factor for systemic lupus erythematosus: results of a nationwide study in Taiwan

Lin, Yu-Chao; Liang, Shinn-Jye; Liu, Yiheng; Hsu, Wu‐Huei; Shih, Chuen-Ming; Sung, Fung‐Chang; Chen, Wei

doi:10.1007/s00296-011-1847-5

Cited by 33 publications

(26 citation statements)

References 19 publications

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“…The SLE mortality risk estimate for surgical hospitalisation is lower than that for all-cause hospitalisation 21. Our result showed a high proportion of men among the patients with SLE, an intriguing fact consistent with previous cohort studies in Taiwan 22 23. Similar to the concurrence of rheumatoid arthritis and SLE reported in an Australian case series,24 an increased prevalence of rheumatoid arthritis was found among our lupus patients.…”

Section: Discussionsupporting

confidence: 92%

Adverse outcomes after major surgery in patients with systemic lupus erythematosus: a nationwide population-based study

et al. 2013

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Section: Discussionsupporting

confidence: 92%

Adverse outcomes after major surgery in patients with systemic lupus erythematosus: a nationwide population-based study

et al. 2013

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“…Although these organ systems could directly be affected by SLE [29], [30], the increased visits might also be caused by infections of these organs. A study based on the Taiwan NHI database demonstrated an increased risk of tuberculosis in patients before their diagnosis of SLE [31]. Nevertheless, the risks of other infectious diseases remain to be investigated.…”

Section: Discussionmentioning

confidence: 99%

Patterns of Ambulatory Medical Care Utilization and Rheumatologist Consultation Predating the Diagnosis of Systemic Lupus Erythematosus: A National Population-Based Study

et al. 2014

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ObjectiveTo investigate the records of ambulatory medical care from patients predating the diagnosis of systemic lupus erythematosus (SLE) using nationwide, population-based claims data.MethodsThe frequencies and costs of ambulatory medical care utilization in 337 newly-diagnosed SLE cases between 2004 and 2010, identified from Taiwan's National Health Insurance Research Database, were compared with 1,348 controls who were frequency matched for sex, age, and the catastrophic illness certificate application year of the cases.ResultsPatients with SLE had a median frequency of ambulatory medical care utilization compared with controls one year prior to the index date (22 vs. 2, P<0.001). The differences were significant throughout all eight annual periods. Similarly, the inflation-adjusted costs of ambulatory medical care utilization in patients with SLE increased annually over the study period, from a median of US$18 eight years prior to the index date to US$680 one year prior to the index date. Diseases of the respiratory system (International Classification of Diseases, Ninth Revision, Clinical Modification [ICD-9-CM] codes 460–519), digestive system (ICD-9-CM codes 520–579), musculoskeletal system and connective tissue (ICD-9-CM codes 710–739, excluding 710.0), and skin and subcutaneous tissue (ICD-9-CM codes 680–709) were the top four common causes of visits in the 0.5 to 2 year period preceding the index date and percentages of SLE patients suffered from these disorders increased progressively over the study period. Only 56.4% of the patients with SLE had consulted a rheumatologist and most of the serology tests were done within one year predating the index date.ConclusionsIncreased frequencies and costs of ambulatory care utilization among Taiwanese patients with SLE occurred several years predating their definitive SLE diagnosis. When multisystemic disorders are presented in young female patients, the possibility of SLE should be considered and screened with tools such as the antinuclear antibody test.

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“…10 Furthermore, some systemic diseases that seem to be related to TB have been reported, such as acute coronary syndrome, liver cirrhosis, systemic lupus erythematosus and Parkinson's disease. [11][12][13][14] Peripheral arterial disease (PAD) is a disease of the circulatory system that decreases blood flow to peripheral tissues, is primarily caused by atherosclerosis and induces tissue injury. The prevalence of PAD is approximately 12-14% in the general population, and the prevalence increases with age to affect 20% of patients over 75 years.…”

Section: Introductionmentioning

confidence: 99%

Tuberculosis increases the risk of peripheral arterial disease: A nationwide population‐based study

et al. 2017

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Background and objective: According to several studies, tuberculosis (TB) may be involved in the pathogenesis of cardiovascular disease. However, the relationship between TB and peripheral arterial disease (PAD) has not been studied. The aim of this study was to investigate whether patients with TB exhibit an increased risk of developing PAD. Methods: The data assessed in this national population-based cohort study were obtained from the Taiwan National Health Insurance Database from 2000 to 2010. Patients with newly diagnosed TB were selected using the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes. The non-TB cohort was randomly frequency-matched to the TB cohort at a ratio of 2:1 according to age, sex and index year. Cox's proportional hazards regression models were used to analyse the risk of PAD. Results: We enrolled 14 350 patients with TB and 28 700 controls in this study. The risk of PAD was 3.93-fold higher in the patients with TB than in the non-TB controls after adjusting for age, sex, co-morbidities and socio-economic status. Based on the subgroup analysis, the TB cohort exhibited an increased risk of developing PAD compared with the non-TB cohort, regardless of age, sex, co-morbidities and socio-economic status. Patients with TB had a higher risk of developing PAD than healthy control subjects after 1 year of follow-up. Conclusion: Patients with TB have a significantly higher risk of developing PAD than patients without TB. TB should be considered when evaluating a patient's risk of developing PAD.

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Tuberculosis as a risk factor for systemic lupus erythematosus: results of a nationwide study in Taiwan

Cited by 33 publications

References 19 publications

Adverse outcomes after major surgery in patients with systemic lupus erythematosus: a nationwide population-based study

Adverse outcomes after major surgery in patients with systemic lupus erythematosus: a nationwide population-based study

Patterns of Ambulatory Medical Care Utilization and Rheumatologist Consultation Predating the Diagnosis of Systemic Lupus Erythematosus: A National Population-Based Study

Tuberculosis increases the risk of peripheral arterial disease: A nationwide population‐based study

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