Tuberculosis and excess alcohol use in the United States, 1997–2012

Volkmann, Tyson; Moonan, Patrick K.; Miramontes, Roque; Oeltmann, John E.

doi:10.5588/ijtld.14.0516

Cited by 49 publications

(39 citation statements)

References 41 publications

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“…Excessive alcohol intake is also associated with lower rates of negative sputum culture conversion and higher rates of mortality (Volkmann et al 2015). In the present study, the gastrectomy group had a higher prevalence of alcohol consumption than the control group (53.3% vs. 6.7%; P < 0.001).…”

Section: Discussionsupporting

confidence: 40%

Treatment Outcomes of Patients Treated for Pulmonary Tuberculosis after Undergoing Gastrectomy

Jung

Kim

Jeong

et al. 2016

Tohoku J. Exp. Med.

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Gastrectomy is a proxy of malnutrition, which may lead to increased risk for developing pulmonary tuberculosis (TB). Malabsorption in gastrectomy patients could lead to low serum levels of rifampicin, which may be related to higher treatment failure. However, there is limited information on treatment outcomes of TB in patients who have undergone gastrectomy. This study aims to determine treatment outcomes and adverse effects in patients treated for TB after undergoing gastrectomy for gastric cancer. During the study period, 112 patients were treated for active TB that developed after gastrectomy for gastric cancer. Among them, we selected 15 patients who were culture positive at initial diagnosis and had evidence of active TB on imaging studies; namely, the remaining 97 patients without initial culture or imaging studies were excluded. We thus performed a case-control study of gastric cancer patients treated for TB after undergoing gastrectomy (n = 15). The control group was defined as age-and sex-matched TB patients who had not received gastrectomy (n = 45). Treatment failure in clinical, microbiological aspects, and adverse events were analyzed. Patients who had undergone gastrectomy exhibited higher 4-month clinical failure rates, compared to non-gastrectomy patient: 4 (26.7%) vs. 1 (2.2%), P = 0.012. Gastrointestinal adverse effects were more frequent in patients with gastrectomy, compared to non-gastrectomy patients: 9 (60%) vs. 5 (11.1%), P < 0.001. In conclusion, patients treated for TB after undergoing gastrectomy are associated with higher rates of gastrointestinal adverse events and treatment failure.

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Section: Discussionsupporting

confidence: 40%

Treatment Outcomes of Patients Treated for Pulmonary Tuberculosis after Undergoing Gastrectomy

Jung

Kim

Jeong

et al. 2016

Tohoku J. Exp. Med.

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“…Recently, the Nigeria National TB Control Programme and its donor partners have commenced the scale-up of availability and accessibility to improved methods for TB diagnosis and effective treatment regimen [5, 6]. While those efforts are needed and well deserved in Nigeria, there are limited pragmatic policy actions to tackle emerging risk factors for TB at the population level, including diabetes [7, 8], alcohol intake [8–11] and tobacco smoking [8, 12]. Country-specific epidemiologic studies which investigate trends in TB disease burden and the attributable risk factors for TB would be useful for public health experts and policy-makers to strengthen TB control and preventive efforts.…”

Section: Introductionmentioning

confidence: 99%

Tuberculosis disease burden and attributable risk factors in Nigeria, 1990–2016

et al. 2018

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BackgroundAccording to the World Health Organization, Nigeria is one of the countries with a high burden of tuberculosis (TB) worldwide. Improving the burden of TB among HIV-negative people would require comprehensive and up-to-date data to inform targeted policy actions in Nigeria. The study aimed to describe the incidence, prevalence, mortality, disability-adjusted life years (DALYs) and risk factors of tuberculosis in Nigeria between 1990 and 2016.MethodsThis study used the most recent data from the global burden of disease study 2016. TB deaths were estimated using the Cause of Death Ensemble model, while TB incidence, prevalence and DALYs, as well as years of life lost and years of life lived with disability were calculated in the DisMod-MR 2.1, a Bayesian meta-regression tool. Using a comparative risk assessment approach, TB burden attributable to risk factors was estimated in a spatial-temporal Gaussian Process Regression tool.ResultsIn 2016, the prevalence of TB among HIV-negative people was 27% (95% uncertainty interval [95% UI] 23–31%) in Nigeria. TB incidence rate (new and relapse cases) was 158 per 100,000 people (95% UI; 128-193), while the total number of TB mortality was 39,933 deaths (95% UI; 30,488-55,039) in 2016. Between 2000 and 2016, the age-standardised prevalence and incidence rates of TB-HIV negative decreased by 20.0 and 87.6%, respectively. The age-standardised mortality rate also dropped by 191.6% over the same period. DALYs due to TB among HIV-negative Nigerians was high but varied across the age groups. Of the risk factors studied, alcohol use accounted for the highest number of TB deaths and DALYs, followed by diabetes and smoking in 2016.ConclusionThe study shows an improving trend in TB disease burden among HIV-negative individuals in Nigeria from 1990 to 2016. Despite this progress, this study suggests that additional efforts are still needed to ensure that Nigeria is not left behind in the current global strategy to end TB disease. Reducing TB disease burden in the country will require a multipronged approach that includes increased funding, health system strengthening and improved TB surveillance, as well as preventive efforts for alcohol use, smoking and diabetes.Electronic supplementary materialThe online version of this article (10.1186/s41182-018-0114-9) contains supplementary material, which is available to authorized users.

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“…[19][20][21] The present study has observed a prevalence of alcohol use among TB patients to be 20.5% (95% CI=13.18% to 27.82%) and all of them were males. However, no significant associated was noted between alcohol use and the type of TB.…”

Section: Resultsmentioning

confidence: 94%

Tobacco smoking trends and treatment outcomes in Tuberculosis patients of district Shimla, Himachal Pradesh, India: a cohort study

Singh

Thakur

Mazta³

et al. 2017

Int J Community Med Public Health

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Background: India carries the highest burden of tuberculosis worldwide. To achieve the goals of the ‘END TB’ strategy, it is imperative to understand the factors which can influence the treatment outcomes. The objectives were to study the socio-demographic characteristics of the subjects and to study the factors influencing treatment outcomes in the TB patients. Methods: A prospective cohort study design was employed and all patients (n=117) who were registered for category I DOTS during the last quarter of 2015 were included after obtaining written informed consent. Home visits with patient interviews were conducted to collect information on determinants. Univariate and binary logistic regression models were employed. Results: The overall treatment success rate was 93.2% (Cure rate=87%, treatment completion rate=100%). Default, death, failure and lost to follow up rates were 2.6%, 2.6%, 0.8% and 0.8% respectively. Those with a history of tobacco smoking [RR: 6 (1.27-28.37); p=0.02], second hand smoke [RR: 8.75 (1.11-68.88); p=0.02], indoor air pollution [RR: 7.89 (1.10-62.13); p=0.02] and alcohol use [RR: 6.13 (1.57-23.93); p=0.01] had higher risks of developing unfavourable treatment outcomes. The commonest cause of indoor air pollution was smoke surfacing out of fire-wood used for cooking and tobacco. Conclusions: The treatment success rates conform to the END TB strategy targets of 90%. Tobacco smoking, second hand smoke, indoor air pollution and alcohol intake were associated with adverse outcomes. Health education regarding the ill effects of tobacco and alcohol with regards to the disease preventability and curability needs to be further intensified. Larger studies to determine the effect of indoor air pollution as a risk factor and its impact on treatment outcomes by contemporary scientific methods by collaborating with other agencies involved in environmental studies is highly recommended.

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Tuberculosis and excess alcohol use in the United States, 1997–2012

Cited by 49 publications

References 41 publications

Treatment Outcomes of Patients Treated for Pulmonary Tuberculosis after Undergoing Gastrectomy

Treatment Outcomes of Patients Treated for Pulmonary Tuberculosis after Undergoing Gastrectomy

Tuberculosis disease burden and attributable risk factors in Nigeria, 1990–2016

Tobacco smoking trends and treatment outcomes in Tuberculosis patients of district Shimla, Himachal Pradesh, India: a cohort study

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