Tuberculosis and diabetes mellitus: sociodemographic and clinical profile in Brazilian municipalities

Beraldo, Aline Ale; Andrade, Rúbia Laine de Paula; Pinto, Erika Simone Galvão; Silva-Sobrinho, Reinaldo Antônio; Saita, Nânci Michele; Monroe, Aline Aparecida; Villa, Tereza Cristina Scatena

doi:10.1590/1983-1447.2021.20200247

Cited by 4 publications

(4 citation statements)

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“…( Martinez et al., 2012 ) also found less immigrants with diabetes mellitus. Although studies report that patients with this disease have greater probability of becoming sick from TB ( Beraldo et al., 2021 ; Demlow et al., 2015 ), such contrariness may be justified by the younger age of the immigrant population analyzed in this study and since an association between TB and diabetes is more frequently found in the age range between 50 and 69 years ( Suwanpimolkul et al., 2014 ).…”

Section: Discussionmentioning

confidence: 77%

Tuberculosis in international immigrants: Profile and vulnerability of cases residing in the municipality of São Paulo, Brazil

Gonçalves

Andrade

Netto

2022

Journal of Migration and Health

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Objective To analyze the profile of immigrants with tuberculosis (TB) and to identify the associated vulnerability characteristics. Methods A cross-sectional study which used TB-WEB data from cases residing in São Paulo in 2016 (203 immigrants and 6,069 non-immigrants). The variables were analyzed using prevalence ratio and confidence intervals. Results Among the immigrant cases, 67% were Bolivians. When compared to non-immigrants, immigrants were younger and frequently indigenous or presenting yellow ethnicity. They were also associated with a higher education level. We observed less immigrants having extrapulmonary TB and comorbidities, such as HIV/AIDS, diabetes mellitus, or drug use. Compared to cured cases, immigrants were not associated with treatment default and death, but they were associated with transfer to another state/country. Conclusions Younger individuals and higher education levels were identified among immigrants, as well as a lower occurrence of comorbidities and drug use. It is believed that these results have led immigrants to more favorable outcomes of TB treatment.

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Section: Discussionmentioning

confidence: 77%

Tuberculosis in international immigrants: Profile and vulnerability of cases residing in the municipality of São Paulo, Brazil

Gonçalves

Andrade

Netto

2022

Journal of Migration and Health

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“…Horizonte, Imperatriz e Campina Grande (ROCHA et al, 2016;SOUSA et al, 2021;LACERDA et al, 2016). No entanto, há um estudo realizado em São Paulo, Paraná e Rio Grande do Norte que apresentou resultados divergentes, apontando para uma maior prevalência da comorbidade em indivíduos do sexo feminino entre os anos de 2010 e 2014 (BERALDO et al, 2021).…”

Section: Resultsunclassified

“…Estudos indicam que ser mulher pode ser um fator de risco, devido à má utilização dos serviços de saúde, ao papel de cuidador para os doentes e à influência do estrogênio na produção de citocinas durante a infecção por TB (WORKNEH et al, 2017). Quando analisado em relação à faixa etária, foi observado uma maior concentração de casos de tuberculose em indivíduos com idade entre 40 e 59 anos (n= 670; 52,5%) (Tabela 1), corroborando com outros estudos (LACERDA et al, 2016;BERALDO et al, 2021;ABREU et al, 2020). No entanto, pesquisas recentes têm apontado um aumento do número de casos em indivíduos com mais de 60 anos (SOUSA et al, 2021), que pode estar relacionado a uma série de fatores.…”

Section: Resultsunclassified

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Aspectos clínicos e epidemiológicos da tuberculose associada a diabetes em alagoas entre 2013 e 2022

De Novaes,

Pinto,

Gomes Filho

et al. 2023

Braz. J. Hea. Rev.

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A tuberculose (TB) é uma doença infectocontagiosa causada pela Mycobacterium tuberculosis, é um problema muito associado a aspectos socioeconômicos, como desnutrição e habitação inadequada, e também a um elemento muito importante que é a existência de comorbidades, por exemplo, infecção pelo HIV e a diabetes. Estudos mostraram que pacientes com Diabetes Mellitus (DM) podem ter de 2,44 a 8,33 vezes mais chances de contrair a infecção e que em 2014, 15% dos casos de TB tinham DM associada. Este estudo objetivou analisar os aspectos clínicos e epidemiológicos da tuberculose associados a diabetes em Alagoas entre 2013-2022. Trata-se de um estudo epidemiológico analítico transversal, onde foram incluídos todos os casos de TB com agravamento associado do DM registrados no Sistema de Informação de Agravos de Notificação (SINAN) no período de janeiro de 2013 a dezembro de 2022 no estado de Alagoas. Para a análise das características epidemiológicas, foram selecionadas as variáveis: como idade, sexo e raça/cor, as informações sobre a residência, como a zona em que se encontram, e dados adicionais sobre o caso, incluindo a forma clínica e situação de encerramento. Foi identificado alguns aspectos relevantes sobre o perfil dos casos de comorbidade tuberculose/diabetes mellitus no estado de Alagoas, incluindo a maior prevalência em homens de meia-idade com baixa escolaridade e pertencimento étnico-racial pardo, com predomínio da forma pulmonar e um maior índice de cura. A TB-DM ainda representa um grande problema de saúde pública, evidenciando a importância do preenchimento adequado das plataformas de saúde para o estado. Assim, destaca-se a importância de aprimorar as políticas públicas de saúde e garantir um tratamento mais efetivo e equitativo para a população afetada por essa comorbidade.

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Prevalence and Clinical Profiling of Dysglycemia and HIV infection in Persons with Pulmonary Tuberculosis in Brazil

Arriaga

Araújo-Pereira

Barreto-Duarte

et al. 2021

Preprint

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BackgroundThere are scarce data on the prevalence and disease presentation of HIV in patients with tuberculosis (TB) and dysglycemia (diabetes [DM] and prediabetes [PDM]), especially in TB-endemic countries.MethodsWe assessed the baseline epidemiological and clinical characteristics of patients with culture-confirmed pulmonary TB, enrolled in a multicenter prospective cohort in Brazil (RePORT-Brazil) during 2015-2019. Dysglycemia was defined by elevated glycated hemoglobin and stratified as PDM or DM. Additionally, we used data from TB cases obtained through the Brazilian National Notifiable Diseases Information System (SINAN), during 2015-2019. In SINAN, diagnosis of diabetes was based on self-report. Logistic regression models were performed to test independent associations between HIV, dysglycemia status, and other baseline characteristics in both cohorts.ResultsIn the RePORT-Brazil cohort, the prevalence of DM and of PDM was 23.7% and 37.8%, respectively. Furthermore, the prevalence of HIV was 21.4% in the group of persons with TB-dysglycemia and 20.5% in that of patients with TBDM. In the SINAN cohort, the prevalence of DM was 9.2%, and among the TBDM group the prevalence of HIV was 4.1%. Logistic regressions demonstrated that aging was independently associated with PDM or DM in both the RePORT-Brazil and SINAN cohorts. In RePORT-Brazil, illicit drug use was associated with PDM, whereas a higher body mass index (BMI) was associated with DM occurrence. Of note, HIV was not associated with an increased risk of PDM or DM in patients with pulmonary TB in both cohorts. Moreover, in both cohorts, the TBDM-HIV group presented with a lower proportion of positive sputum smear and a higher frequency of tobacco and alcohol users.ConclusionThere is a high prevalence of dysglycemia in patients with pulmonary TB in Brazil, regardless of the HIV status. This reinforces the idea that DM should be systematically screened in persons with TB. Presence of HIV does not substantially impact clinical presentation in persons with TBDM, although it is associated with more frequent use of recreational drugs and smear negative sputum samples during TB screening.

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Tuberculosis and diabetes mellitus: sociodemographic and clinical profile in Brazilian municipalities

Cited by 4 publications

References 13 publications

Tuberculosis in international immigrants: Profile and vulnerability of cases residing in the municipality of São Paulo, Brazil

Tuberculosis in international immigrants: Profile and vulnerability of cases residing in the municipality of São Paulo, Brazil

Aspectos clínicos e epidemiológicos da tuberculose associada a diabetes em alagoas entre 2013 e 2022

Prevalence and Clinical Profiling of Dysglycemia and HIV infection in Persons with Pulmonary Tuberculosis in Brazil

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