Tuberculosis and autoimmunity: Common features

Старшинова, Анна; Малкова, Анна; Kudryavtsev, I. V.; Kudlаy, D.А.; Zinchenko, Ulia; Yаblonskiy, Petr

doi:10.1016/j.tube.2022.102202

Cited by 14 publications

(12 citation statements)

References 58 publications

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“…These may be the reasons for the short-term risk of both diseases. Second, Mtb infection may trigger autoimmune reactions by molecular mimicry of Mtb antigens with human proteins ( 51 ) and infection may subsequently result in autoimmune thyroid diseases ( 22 ). Third, asymptomatic populations of hypothyroidism and TB may result in delayed diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Bidirectional Relationship Between Tuberculosis and Hypothyroidism: An 18-Year Nationwide Population-Based Longitudinal Cohort Study

et al. 2022

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Some antituberculosis agents may cause hypothyroidism, and thyroid hormones play a vital role in Mycobacterium tuberculosis infection. However, the relationship between tuberculosis (TB) and hypothyroidism has not been clearly established. Therefore, this retrospective, longitudinal cohort study aimed to investigate the association between these two diseases using the 2000–2017 data from the Taiwan's National Health Insurance Research Database. The hypothyroidism and TB cohorts were matched with the control group in a 1:4 ratio. Adjusted hazard ratios (aHRs) were assessed using Cox proportional hazards regression analysis in each cohort. In total, 3,976 individuals with hypothyroidism and 35 120 individuals with TB were included in this study. The risk of developing TB in patients with hypothyroidism was 2.91 times higher than that in those without hypothyroidism (95% confidence interval [CI], 1.50–3.65). The subgroup of thyroxine replacement therapy (TRT) had a 2.40 times higher risk (95% CI, 1.26–3.01), whereas the subgroup of non-TRT had a 3.62 times higher risk of developing TB than those without hypothyroidism (95% CI, 2.19–4.84). On the other hand, the risk of developing hypothyroidism in patients with TB was 2.01 times higher than that in those without TB (95% CI, 1.41–2.38). Our findings provide evidence that TB and hypothyroidism are interrelated. Thus, clinicians and public health authorities should monitor the association between these two diseases to reduce the relevant disease burden.

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Section: Discussionmentioning

confidence: 99%

Bidirectional Relationship Between Tuberculosis and Hypothyroidism: An 18-Year Nationwide Population-Based Longitudinal Cohort Study

et al. 2022

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“…The autoimmune nature theory of this disease initiated numerous studies ( 15 , 20 ). In the past few years, vimentinhas gained the attention as a potential autoantigen in some diseases.…”

Section: Introductionmentioning

confidence: 99%

“…Vimentin is a cytoskeletal component that presents in the connective tissue and participates in the intercellular interactions and the functioning of the immune system. The occurrence of ААВ to this protein was observed in rheumatoid arthritis, systemic lupus erythematosus and many other connective tissue diseases ( 20 , 21 ). The presence of autoantibodies in tuberculosis was documented by large amount of studies ( 22 – 24 ).…”

Section: Introductionmentioning

confidence: 99%

“…Several possible mechanisms can be suggested. It may be excessive cell death with impaired clearance of dead cells, impaired autophagy, enhanced activation of macrophages and dendritic cells by MBT as an adjuvant, and also environmental influences, facilitating both Tbc and autoimmune processes in parallels ( 20 , 26 ). Improved interventions could have a substantial effect on our ability to decrease the morbidity and mortality associated with the disease and limitation further spread, as effective treatment of active Tbc is the major modality for preventing transmission in most of the world.…”

Section: Introductionmentioning

confidence: 99%

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Identification of autoimmune markers in pulmonary tuberculosis

et al. 2023

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IntroductionPathogenesis of many autoimmune diseases is mainly promoted by poorly regulated and/or wrong targeted immune response to pathogens including M. tuberculosis. Autoimmunity is one of the processes with are characteristics of tuberculosis (Tbc). The aim was to determine the autoimmune clinical and immunological features in patients with pulmonary Tbc.Materials and methodsA prospective comparative study was performed in 2017 – 2019 with the inclusion of 46 patients with Tbc. The trigger factors and clinical manifestations, autoantibodies, peripheral blood B cell subsets were stained with fluorochrome-conjugated monoclonal antibodies. 40 healthy volunteers in the control group, were matched for age with no chronic diseases, contacts with TB patients and changes in their laboratory parameters. A statistical analysis was done with GraphPad Prism 6, Statistica 10 (Statsoft) and MedCalc – version 18.2.1 values.ResultsThere were no significant ASIA triggers in Tbc patients and control group. 21.1% of Tbc patients had a high level of a rheumatoid factor and in 47.4% complement system factor C3 was high; anti-MCV was detected in 60.7% of Tbc patients. Relative and absolute frequencies of “naïve” Bm1 cells and eBm5 were significantly decreased and activated pre-germinal-center Bm2’ cells were significantly increased in Tbc patients. The CD24++CD38++ B cells were increased in Tbc vs control group (10.25% vs 5.42%), p < 0.001, and 19 cell/1μL (10; 290 vs 11 cell/1μL (6; 20), p = 0.029, respectively). The frequency of CXCR3+CCR4– Tfh1 cells was significantly lower in Tbc vs control one (26.52% vs. 31.00%, p = 0.004), while CXCR3–CCR4+ Tfh2 cells were increased in Tbc (20.31% vs. controls (16.56%, p = 0.030). The absolute numbers of Tfh1 cells were decreased in the Tbc vs. control (24 cell/1μL vs. 37 cell/1μL p = 0.005).ConclusionThe results of our study showed that the detection of a rheumatoid factor, the components of complement system and anti-MCV in complex with alterations in B cells and follicular Th cell subsets may indicate a presence of autoimmunity in the pathogenesis of tuberculosis, but they are not specific. The indicators of autoimmune-related provide new opportunities in the Tbc treatment.

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“…Therapeutic strategies for TB have been well established, and most patients achieve recovery after a regular course of treatment. However, in recent years, with the increasing incidence of drug-resistant TB, the cooccurrence of various TB complications, and hypoimmunity of patients themselves, the incidence of TB is showing a resurgence (2). According to the 2021 Global TB Study, the number of new cases in China was 842,000 in 2020, ranking second to India among the 30 countries with high TB burden globally (3).…”

Section: Introductionmentioning

confidence: 99%

B and T lymphocyte attenuator as a C-reactive protein and IgA associated auxiliary diagnostic marker for pulmonary tuberculosis: a case-control study

Xu¹,

Bian²,

Wang³

et al. 2022

Ann Transl Med

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Background: Screening and identification of hematologic molecular indicators of pulmonary tuberculosis (PTB) is crucial for its diagnose and therapy. Therefore, our work aims to detect the diagnostic value of blood marker B and T lymphocyte attenuator (BTLA) in PTB, and provide a certain theoretical basis for the auxiliary diagnosis of PTB. Methods: Based on the inclusion criteria, 56 Patients with clinically confirmed pulmonary TB by clinical between January 2020 and December 2021 at our hospital were selected as the research objects of this study. Fifty-two matched healthy population at our hospital was used as the control group. Clinical characteristics were got from clinical laboratory. Real-time polymerase chain reaction (RT-PCR) was used to analyze changes in BTLA along with its ligand in peripheral blood. Changes in BTLA on the surface of different cells were analyzed by flow cytometry. The correlation test was used to determine the associations between BTLA and clinical indicators. Receiver operating characteristic (ROC) curve analysis was used to evaluate the auxiliary diagnostic value in PTB of BTLA expression from different sources.Results: Compared with the control, changes in peripheral blood BTLA in the PTB group were significantly increased (P=0.0187) rather than its ligand. Changes in BTLA on the surface of CD68 and antigen-presenting cell (APC) CD11c were significantly increased in the PTB group (P=0.0004, P<0.0001), while changes in BTLA on the surface of CD4 + T and CD8 + T cells were not significantly different (P=0.0792, P=0.8706). The expression of BTLA + CD11c + was negatively correlated with the expression of immunoglobulin A (IgA) (r=−0.2934, P=0.0282) and positively related to C-reactive protein (r=0.3277, P=0.0137). ROC curve analysis suggested that the area under the curve (AUC), sensitivity and specificity of BTLA RT-PCR detection were 0.6315, 53.57%, 57.69% while for BTLA + CD11c + detection were 0.8039, 88.46% and 73.21% and for BTLA + CD68 + detection were 0.6973, 60.71% and 61.54%.Conclusions: BTLA is highly expressed in peripheral blood and specific cell types of patients with PTB and is correlated with specific clinical indicators, which may be an important molecular marker for the auxiliary diagnosis of PTB.

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Tuberculosis and autoimmunity: Common features

Cited by 14 publications

References 58 publications

Bidirectional Relationship Between Tuberculosis and Hypothyroidism: An 18-Year Nationwide Population-Based Longitudinal Cohort Study

Bidirectional Relationship Between Tuberculosis and Hypothyroidism: An 18-Year Nationwide Population-Based Longitudinal Cohort Study

Identification of autoimmune markers in pulmonary tuberculosis

B and T lymphocyte attenuator as a C-reactive protein and IgA associated auxiliary diagnostic marker for pulmonary tuberculosis: a case-control study

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