Tuberculosis, acute kidney injury and pancreatitis--what is the underlying cause?

Topping, Kate; Nair, Beena; Ahmed, Aimun; Woywodt, Alexander

doi:10.1093/ckj/sfs084

Cited by 1 publication

(4 citation statements)

References 5 publications

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“…Another evidence that Dapsone was the most likely cause of the patient’s acute pancreatitis is the dosage of MB-PCT. The doses of Dapsone from this patient’s therapy are similar to those found in the literature, unlike Rifampicin, whose dosage was much lower than those reported in the other case reports 2 , 6 - 13 .…”

Section: Discussionsupporting

confidence: 85%

“…All reported cases of dapsone-induced cases were in male patients. AP associated with rifampicin affected both genders, with at least four weeks of medication use 10 - 13 .…”

Section: Discussionmentioning

confidence: 99%

“…Cutaneous symptoms and other systemic disorders were reported as well. In cases associated with Rifampicin, systemic signs and injuries were more common 2 , 6 - 13 .…”

Section: Discussionmentioning

confidence: 99%

“…Nine cases of acute pancreatitis associated with medications for the multidrug therapy of leprosy were reported. Five of these cases were of patients using dapsone, with similar dosage to the PCT/MB, while four cases are related to the use of rifampicin in higher doses 5 - 13 .…”

Section: Introductionmentioning

confidence: 99%

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Acute pancreatitis associated with multibacillary polychemotherapy for leprosy

Maciel

França

Deus

et al. 2021

Rev. Inst. Med. trop. S. Paulo

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Acute pancreatitis (AP) is an inflammatory disease associated with abdominal pain and elevated serum pancreatic enzymes. The most common etiologies are gallstones and alcoholism. Drug-induced AP is quite rare, lacks a solid understanding and has been occasionally reported. The diagnosis requires a great suspicion and a careful exclusion of other causes. We present a case of a 37-year-old man, previously diagnosed with leprosy that developed acute pancreatitis after starting the multibacillary polychemotherapy (PCT/MB). After a month of treatment and the discontinuation of the PCT/MB, the therapy was restarted and a new episode of AP occurred. Three months after this last episode, the PCT/MB was reintroduced, changing one of the medications and the patient had no recurrence of AP or other reactions. Therefore, it is important to take into account that there is a risk of acute pancreatitis in patients on multidrug therapy (MDT) for leprosy.

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Section: Discussionsupporting

confidence: 85%

“…All reported cases of dapsone-induced cases were in male patients. AP associated with rifampicin affected both genders, with at least four weeks of medication use 10 - 13 .…”

Section: Discussionmentioning

confidence: 99%

“…Cutaneous symptoms and other systemic disorders were reported as well. In cases associated with Rifampicin, systemic signs and injuries were more common 2 , 6 - 13 .…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations