Tuberculose pulmonar: associação entre extensão de lesão pulmonar residual e alteração da função pulmonar

Cruz, Rita de Cassia Santa; Albuquerque, Maria de Fátima Pessoa Militão de; Campelo, Antônio Roberto Leite; Silva, Eduardo Just da Costa e; Mazza, Edmílson; Menezes, Renata Carneiro de; Kosminsky, Samuel

doi:10.1590/s0104-42302008000500012

Cited by 23 publications

(22 citation statements)

References 17 publications

(13 reference statements)

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“…These data suggest that healthy people had highly homogenous bacterial flora, while TB patients had a significantly altered bacterial community and a disappearance of any similarity. We interpreted the lack of homology as follows: from classical knowledge of TB pathology, Mycobacteria invasion is an important factor in injuring the mucosal barrier in the LRT, facilitating the colonisation of bacteria from the URT or foreign environments [ 24 ]. Our colleagues Cui et al have found that many rare, unique bacteria exist in the microbiota of sputum from TB patients compared with that of healthy individuals, indicating its important role in creating the diversity in TB microbiota [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Correlation between Either Cupriavidus or Porphyromonas and Primary Pulmonary Tuberculosis Found by Analysing the Microbiota in Patients’ Bronchoalveolar Lavage Fluid

et al. 2015

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Pulmonary tuberculosis (TB) has gained attention in recent decades because of its rising incidence trend; simultaneously, increasing numbers of studies have identified the relationship between microbiota and chronic infectious diseases. In our work, we enrolled 32 patients with primary TB characterised by unilateral TB lesion formation diagnosed by chest radiographic exam. Bronchoalveolar lavage fluid was taken from both lungs. Twenty-four healthy people were chosen as controls. Pyrosequencing was performed on the V3 hypervariable region of 16S rDNA in all bacterial samples and used as a culture-independent method to describe the phylogenetic composition of the microbiota. Through pyrosequencing, 271,764 amplicons were detected in samples and analysed using tools in the Ribosomal Database Project (RDP) and bioinformatics. These analyses revealed significant differences in the microbiota in the lower respiratory tract (LRT) of TB patients compared with healthy controls; in contrast, the microbiota of intra/extra-TB lesions were similar. These results showed that the dominant bacterial genus in the LRT of TB patients was Cupriavidus and not Streptococcus, which resulted in a significant change in the microbiota in TB patients. The abundance of Mycobacteria and Porphyromonas significantly increased inside TB lesions when compared with non-lesion-containing contralateral lungs. From these data, it can be concluded that Cupriavidus plays an important role in TB’s secondary infection and that in addition to Mycobacteria, Porphyromonas may also be a co-factor in lesion formation. The mechanisms underlying this connection warrant further research.

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Section: Discussionmentioning

confidence: 99%

Correlation between Either Cupriavidus or Porphyromonas and Primary Pulmonary Tuberculosis Found by Analysing the Microbiota in Patients’ Bronchoalveolar Lavage Fluid

et al. 2015

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“…Case 3 shows a concomitant infection by M. hodleri , with very exuberant lung lesions. All patients described abandoned treatment, and had cavitary and fibro residual lesions and treatment failure, and showed no HIV coinfection, which is an association commonly described in the literature [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…Chest radiography predicts tuberculosis prognosis by evaluating pulmonary lesions [ 7 ], and it is still the most used imaging method [ 8 ]. Cavitary lesions and residual fibrosis found related to multidrug resistance corroborate the literature [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

Resistant tuberculosis in Maranhão, Brazil: a case series

et al. 2016

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BackgroundMycobacterium tuberculosis multidrug resistance, especially against rifampicin and isoniazid, places pulmonary tuberculosis in the list of emerging diseases. The misuse of therapeutic regimens is one of its main predisposing factors.Case presentationFour clinical cases (three were brown and one black) with multidrug-resistant tuberculosis, treated in a reference hospital in the state of Maranhão, Brazil, were reported to evaluate the importance of radiological framework on disease evolution.ConclusionThe clinical framework showed a bad evolution and drug resistance, while radiology showed lung lesions, ranging from exudative infiltrates to lung parenchyma disintegration.

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“… 11 However, OLD was observed in 33% of the patients evaluated by Di Naso et al 13 and in 49% of those evaluated by Nihues et al 14 At another center, RLD was the most prevalent (in 41%). 15 …”

Section: Introductionmentioning

confidence: 99%

Spirometry results after treatment for pulmonary tuberculosis: comparison between patients with and without previous lung disease: a multicenter study

Mancuzo¹,

Netto²,

Sulmonett³

et al. 2020

J Bras Pneumol.

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Objective: To compare patients with and without previous lung disease, in terms of the spirometry results after they had been treated for pulmonary tuberculosis (PTB) and cured, as well as to analyze risk factors related to functional severity. Methods: This was a cross-sectional, multicenter study conducted at four referral centers in Brazil. Patients were divided into two groups: those with a history of lung disease or smoking (LDS+ group); and those with no such history (LDS− group). Patients underwent spirometry (at least six months after being cured). Sociodemographic and clinical data were collected. Results:A total of 378 patients were included: 174 (46.1%) in the LDS+ group and 204 (53.9%) in the LDS− group. In the sample as a whole, 238 patients (62.7%) had spirometric changes. In the LDS+ group, there was a predominance of obstructive lung disease (in 33.3%), whereas restrictive lung disease predominated in the LDS− group (in 24.7%). Radiological changes were less common in the LDS− group than in the LDS+ group (p < 0.01), as were functional changes (p < 0.05). However, of the 140 (79.1%) LDS− group patients with a normal or minimally altered chest X-ray, 76 (54%) had functional changes (p < 0.01). The risk factors associated with functional severity in the LDS− group were degree of dyspnea (p = 0.03) and moderate or severe radiological changes (p = 0.01). Conclusions: Impaired pulmonary function is common after treatment for PTB, regardless of the history of lung disease or smoking. Spirometry should be suggested for patients who develop moderate/severe dyspnea or relevant radiological changes after treatment for PTB.

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Tuberculose pulmonar: associação entre extensão de lesão pulmonar residual e alteração da função pulmonar

Cited by 23 publications

References 17 publications

Correlation between Either Cupriavidus or Porphyromonas and Primary Pulmonary Tuberculosis Found by Analysing the Microbiota in Patients’ Bronchoalveolar Lavage Fluid

Correlation between Either Cupriavidus or Porphyromonas and Primary Pulmonary Tuberculosis Found by Analysing the Microbiota in Patients’ Bronchoalveolar Lavage Fluid

Resistant tuberculosis in Maranhão, Brazil: a case series

Spirometry results after treatment for pulmonary tuberculosis: comparison between patients with and without previous lung disease: a multicenter study

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