Tuberculomas of the brain in Britain

Maurice‐Williams, R. S.

doi:10.1136/pgmj.48.565.678

Cited by 53 publications

(9 citation statements)

References 8 publications

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“…In 1933 a survey of postmortem records (Garland and Armitage, 1933) revealed that 3400 of all cerebral tumours were tuberculomas. By 1940 an analysis of 2,190 brain tumours collected from recent reviews (Wilson, 1940) showed that only 3 6'/ were tuberculomas and a more recent review (Maurice-Williams, 1972) demonstrated an incidence of 0-15%0 among 2,200 intracranial tumours seen at the Guy's-Maudsley neurosurgical unit from 1951-1972. In 1970 Kocen and Parsons (1970) drew attention to some unusual neurological complications of tuberculosis, particularly in non-European immigrants, though none of their patients had intracranial tuberculomas. We wish to report three patients with verified intracranial tuberculomas who have presented to this unit in the past 12 months.…”

mentioning

confidence: 99%

Three patients with intracranial tuberculomas with unusual features

Thrush

Barwick

1974

Journal of Neurology, Neurosurgery & Psychiatry

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confidence: 99%

Three patients with intracranial tuberculomas with unusual features

Thrush

Barwick

1974

Journal of Neurology, Neurosurgery & Psychiatry

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“… 1 The majority of our understanding of the disease process comes from reports such as these, since during the same period one Western author noted only three cases at a British neurosurgical service that had treated 2200 intracranial tumors. 9 Since that era there have been decreasing numbers of reports, as a PubMed search revealed only five non-overlapping large case series with at least 50 patients in the contemporary English medical literature, i.e ., the last five decades. 1 , 2 , 10 , 11 …”

Section: Discussionmentioning

confidence: 99%

Brain Tuberculoma in a Non-endemic Area

Lober

Veeravagu

Singh

2013

Infectious Disease Reports

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Brain tuberculoma has previously accounted for up to a third of new intracranial lesions in areas endemic with tuberculosis, but is unexpected in the United States and other Western countries with improved disease control. Here we show the importance of considering this diagnosis in at-risk patients, even with no definitive pulmonary involvement. We describe a young man who presented with partial seizures and underwent craniotomy for resection of a frontoparietal tuberculoma. He subsequently completed six months of antituberculosis therapy and was doing well without neurological sequelae or evidence of recurrence five months after completion of therapy. With resurgence of tuberculosis cases in the United States and other Western countries, intracerebral tuberculoma should remain a diagnostic consideration in at-risk patients with new space occupying lesions. Mass lesions causing neurological sequelae can be safely addressed surgically and followed with antituberculosis therapy.

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“…Mycobacteria other than the tubercle bacillus, which are responsible for 0·15% to 4·0% of intracranial tumours in western countries (Kummer et al ., 1981; Maurice‐Williams, 1972), represent a novel agent of pituitary granuloma. These bacteria are usually nonpathogenic for humans, but occasionally cause progressive and potentially destructive diseases.…”

Section: Discussionmentioning

confidence: 99%

Isolated pituitary granuloma by atypical Mycobacterium in a nonimmunosuppressed woman

Florakis

Kontogeorgos

Anapliotou

et al. 2002

Clinical Endocrinology

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A 32-year-old woman presented with a 10-day history of fever (38.0 degrees C), headaches, nausea, vomiting and a 6-month history of diabetes insipidus and amenorrhoea. Two months previously she had undergone a surgical drilling of the right mastoid area because of mastoiditis. Endocrine investigation showed elevated serum prolactin levels, secondary adrenal and gonadal failure and a normal thyroid function. Cranial MRI scan revealed a contrast enhancing intrasellar mass (approximately 2 cm) of heterogeneous appearance with suprasellar extension and thickening of the pituitary stalk. Lumbar puncture was suggestive of aseptic meningitis. The Ziehl-Neelsen stain of cerebrospinal fluid (CSF) and the tuberculin skin test were both negative. The pituitary mass was removed with a transsphenoidal approach. Histological examination demonstrated destruction of the adenohypophysis by epithelioid granulomas with partial caseous necrosis and microabscess formation, suggestive of a mycobacterial infection. A polymerase chain reaction analysis performed on paraffin-embedded tissue was positive for mycobacterial DNA. According to the individual 16S sequence, it was identified as Mycobacterium malmoense, an atypical nontuberculous mycobacterium (NTM). In conclusion, this is the first case of an isolated pituitary granuloma caused by an NTM infection in a nonimmunosuppressed patient.

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Tuberculomas of the brain in Britain

Abstract: Summary Reports of three patients with tuberculomas of the brain are presented. The mode of presentation and clinical features of this condition are reviewed.

Cited by 53 publications

References 8 publications

Three patients with intracranial tuberculomas with unusual features

Three patients with intracranial tuberculomas with unusual features

Brain Tuberculoma in a Non-endemic Area

Isolated pituitary granuloma by atypical Mycobacterium in a nonimmunosuppressed woman

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