Tuberculin Skin Test Reactions

Fine, Max; Furcolow, Michael L.; Chick, Ernest W.; Bauman, David S.; Arik, Muhammet Kasım

doi:10.1164/arrd.1972.106.5.752

Cited by 4 publications

(2 citation statements)

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“…There is a tendency of under-reading when the size of induration is between 5-14 mm, which is around the standard cutoff point (≥ 10 mm). Edwin L et al also reported a similar tendency to under-read size of induration among health professionals [10]. In their study, 33% of positive cases were wrongly assigned as Mantoux-negative which is slightly higher than that observed in our study (22.1%).…”

Section: Discussioncontrasting

confidence: 50%

Mantoux test revisited: Variability in reading tuberculin test in pediatric population

Goel

Mantan

Sethi

2018

J Infect Dev Ctries

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Introduction: Mantoux test aids in the diagnosis of tuberculosis (TB), however its application and interpretation are dependent on multiple factors. Methodology: A prospective study enrolling 400 children (aged 2-12) suspected to have tuberculosis. All participants received Mantoux test with two different strengths (1 TU and 5 TU) of Purified Protein Derivative (PPD) on different forearms. The test was read by two readers after 48 ± 2 and 72 ± 2 hours. Primary outcome was difference in the size of induration when read by two readers (interobserver variability). Secondary outcomes were difference in the size of induration at different intervals, with different strengths of PPD and percentage positivity of Mantoux test in TB patients. Results: Statistically significant difference was seen in the size of induration when read by two different readers, with fair to moderate agreement when read at 48 and 72 hours (1 TU: p = 0.002, k = 0.52 and p = 0.1, k = 0.73 respectively, 5 TU: p = 0.001, k = 0.39 and p = 0.0009, k = 0.33 respectively). Tendency of under-reading occurred when size of induration was close to significant level (10-14 mm). Size of induration was similar when read at 48 or 72 hours (1 TU: p = 0.9, 5 TU: p = 1.0). Mantoux positivity rate in patients with TB was more with 5 TU as compared to 1 TU (61.2% vs. 16.3%). Conclusions: There is significant interobserver variability with a tendency to under-read around the cutoff point. The use of 5 TU PPD at 48 hours by a trained physician can aid in early and more reliable diagnosis of TB.

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Section: Discussioncontrasting

confidence: 50%

Mantoux test revisited: Variability in reading tuberculin test in pediatric population

Goel

Mantan

Sethi

2018

J Infect Dev Ctries

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“…5 Fine and colleagues studied 189 subjects using four different observers and found classification disagreements in 12 per cent of tuberculin test readings. 6 The results of our study show that interobserver disagreement on classification of tuberculin reactions can be reduced to 4.3 per cent. This low number of classification disagreements is most likely a result of the training and experience of the readers.…”

Section: Methodsmentioning

confidence: 55%

A demonstration of lack of variability among six tuberculin skin test readers.

Pérez‐Stable¹,

Slutkin²

1985

Am J Public Health

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The variability of tuberculin skin test readings among six trained and experienced readers was evaluated using a modified sliding caliper method. Each of 537 tests were read independently by two readers. There were 23 disagreements between paired readers resulting in an overall interobserver reliability of 95.7 per cent. In 82 per cent of the paired readings the results were different by 2 mm or less. The observer lack of variability was likely due to the training and experience of the readers. (Am J Public Health 1985; 75:1341-1343

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Multiple-puncture tuberculin testing: Reason for variable response to tine test

Herzog

1981

Tubercle

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Tuberculin Skin Test Reactions

Cited by 4 publications

References 0 publications

Mantoux test revisited: Variability in reading tuberculin test in pediatric population

Mantoux test revisited: Variability in reading tuberculin test in pediatric population

A demonstration of lack of variability among six tuberculin skin test readers.

Multiple-puncture tuberculin testing: Reason for variable response to tine test

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