Tuberculin Skin Test and QuantiFERON-TB Gold Assay before and after Treatment for Latent Tuberculosis Infection among Health Care Workers in Local Tertiary Hospital

Lee, Seung Jun; Kim, Hyeon Sik; Eun, Jung Nam; Lee, Sang Min; Ham, Hyun Seok; Cho, Yu Ji; Jeong, Yi Yeong; Kim, Ho Cheol; Lee, Jong Deok; Hwang, Young Sil

doi:10.4046/trd.2007.62.4.270

Cited by 2 publications

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“…One study examined changes in the tuberculin skin test and the QuantiFERON-TB Gold assay before and after treatment for latent tuberculosis in health care workers at a local university hospital. Among 48 participants (14 doctors, 34 nurses), test-results were positive as markers of latent tuberculosis in 25-39.6% of study subjects respectively ( 19 ). A prevalence ratio for latent tuberculosis in health care workers compared with the general population was calculated.…”

Section: High Risk Groupsmentioning

confidence: 99%

Occupational Infection in Korea

2010

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Occupational infection is a human disease caused by work-associated exposure to microbial agents through human and environmental contact. According to the literature, occupational infection was the third leading cause of occupational disease (861 cases, 8.0%), and health care, agricultural, forestry, and fishery workers were risk groups in Korea. In addition, most high-risk groups have not been protected by workers' compensation, which could lead to underestimation of the exact spectrum and magnitude of the problem, and may also result in a lack of development and implementation of occupational infection management. Through a review of national guidelines and documentations on prevention and control of occupational infection, a management strategy would promote adherence to worker safety regulations if it is explicit with regard to the agent and mode of infection in each of the high-risk groups.

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Section: High Risk Groupsmentioning

confidence: 99%

Occupational Infection in Korea

2010

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“…Korea has an intermediate tuberculosis (TB) burden, and the annual incidence of new active TB cases in this country is estimated to be 71.3 in 100,000 people [ 1 , 2 ]. Recently, there have been reports regarding the latent tuberculosis infection (LTBI) rate among Korean healthcare workers and individuals who have been in close contact with active pulmonary TB patients [ 3 - 6 ].…”

Section: Introductionmentioning

confidence: 99%

A prospective cohort study of latent tuberculosis in adult close contacts of active pulmonary tuberculosis patients in Korea

Park

Lee

Cho

et al. 2016

Korean J Intern Med

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Background/Aims:The objective of this prospective study was to evaluate the diagnosis and treatment of latent tuberculosis infection (LTBI) in adult close contacts of active pulmonary tuberculosis (TB) patients in Korea.Methods:Adult close contacts of active pulmonary TB patients were recruited at a regional tertiary hospital in Korea. The participants were tested for LTBI using the tuberculin skin test (TST) and/or QuantiFERON-TB Gold (QFT-G) test. LTBI patients, who consented to treatment, were randomly assigned to receive isoniazid for 9 months (9INH) or rifampin for 4 months (4RIF).Results:We examined 189 adult close contacts (> 18 years) of 107 active pulmonary TB patients. The TST and QFT-G were positive (≥ 10 mm) in 75/183 (39.7%) and 45/118 (38.1%) tested participants, respectively. Among 88 TST or QFT-G positive LTBI participants, 45 participants were randomly assigned to receive 4RIF (n = 21) or 9INH (n = 24), respectively. The average treatment duration for the 4RIF and 9INH groups was 3.3 ± 1.3 and 6.1 ± 2.7 months, respectively. Treatment was completed in 25 participants (4RIF, n = 16; 9INH, n = 9). LTBI participants who accepted treatment were more likely to be women and have more cavitary lesions on the chest radiographs of index cases and positive TST and QFT-G results compared to those who refused treatment.Conclusions:About 40% of adult close contacts of active pulmonary TB patients had LTBI; about 50% of these LTBI participants agreed to treatment.

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Tuberculin Skin Test and QuantiFERON-TB Gold Assay before and after Treatment for Latent Tuberculosis Infection among Health Care Workers in Local Tertiary Hospital

Cited by 2 publications

References 18 publications

Occupational Infection in Korea

Occupational Infection in Korea

A prospective cohort study of latent tuberculosis in adult close contacts of active pulmonary tuberculosis patients in Korea

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