Tuberculin Conversion in Leprous Families in Northern Nigeria

Jamison, D. G.; Vollum, R. L.

doi:10.1016/s0140-6736(68)91763-7

Cited by 16 publications

(8 citation statements)

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“…Absence of lymphocyte transformation in the presence of PHA is characteristic of diseases affecting thymic function such as congenital absence of the thymus (Lischner et al, 1967). Quantitative decreases in cell-mediated responses to antigen were found in rats thymec-tomized as late as 30 days after birth (Jankovic et ul., 1962), and are also found in acquired human diseases such as leprosy Jamison and Vollum, 1968) and Hodgkin's disease (Hersh and Oppenheim, 1965). One effect of depressed cell-mediated immunity may be a lowering of host resistance to infection (Mackeness and Blanden, 1967) , resulting in a change in the dynamic balance between host and organism, and possibly reflected in the high loads of endemic infection and hypergammaglobulinaemia in Group I Aboriginal children.…”

Section: Discussionmentioning

confidence: 99%

Humoral and Cellular Immune Responses to Streptococci, Influenza and Other Antigens in Australian Aboriginal School Children

Jose

Welch

Doherty

1970

J Paediatr Child Health

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SYNOPSIS Aboriginal school children with elevated erythrocyte sedimentation rates were selected, and associated features of growth retardation, hyperimmunoglobulinaemia, high streptococcal carrier rates and antibody levels, and high loads of bowel parasite infestation, noted previously, were confirmed. Medical records showed these children to have had significant growth retardation in infancy, which suggested an association with previous protein‐calorie malnutrition. Antibody responses of these children to influenza vaccine were significantly poorer than controls, both in the magnitude of antibody rise and the proportion of children showing significant rises in titre. Some improvement in antibody response followed treatment of chronic streptococcal infection, or of bowel parasites. Cell‐mediated immune responses, as measured by lymphocyte transformation in vitro in response to specific antigens streptolysin O, tetanus toxoid, non‐specific mitogens PHA and streptolysin S, and also by delayed hypersensitivity reactions to monilia antigen on skin testing, were diminished in children with high ESR, relative to controls. However, enhanced cellular responses in the abnormal children occurred to influenza A2 antigen, and to streptococcal group A polysaccharide, the latter possibly explaining chronic low‐grade tissue damage noted previously in these children. These findings are discussed in relation to resistance to infection and the pathogenesis of rheumatic fever, and a possible basis suggested in acquired change in function of the thymus, perhaps related to protein‐calorie malnutrition in infancy.

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Section: Discussionmentioning

confidence: 99%

Humoral and Cellular Immune Responses to Streptococci, Influenza and Other Antigens in Australian Aboriginal School Children

Jose

Welch

Doherty

1970

J Paediatr Child Health

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“…Jamison and Vollum [6] suggested that leprosy occurred in families in which there was natural defect in ability to develop cellmediated immunity.…”

Section: Subjectsmentioning

confidence: 99%

“…Recent studies have confirmed that there is depression of cell-mediated immune response in leprosy, to a lesser degree in the tuberculoid than the lepromatous type [l, 91. Jamison and Vollum [6] suggested that leprosy occurred in families in which there was natural defect in ability to develop cellmediated immunity. HLA antigens are determined by genes within the MHC region on autosoma1 chromosome [6] and it has been suggested that HLA antigens play a role in the generation of antibodies.…”

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confidence: 99%

“…Jamison and Vollum [6] suggested that leprosy occurred in families in which there was natural defect in ability to develop cellmediated immunity. HLA antigens are determined by genes within the MHC region on autosoma1 chromosome [6] and it has been suggested that HLA antigens play a role in the generation of antibodies. More recently, many studies have shown associations of certain HLA antigens with several diseases, such as systemic lupus erythematosus [5], active chronic hepatitis [S], and Hodgkin's disease [4].…”

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confidence: 99%

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The Incidence of HLA Antigens in Leprosy

Youngchaiyud¹,

Chandanayingyong²,

Vibhatavanija³

1977

Vox Sanguinis

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“…(iii) Innate factors There is no evidence for a genetic factor in syphilis being responsible for the incomplete immune response. In contrast to leprosy (Newell, 1966;Jamison and Vollum, 1968) there is a universal susceptibility to syphilis, with no genetic or racial variation in the essential features of the clinical disease. Also, it has been found that organ-specific antibody formation, for which there is some familial basis, is much the same in patients with syphilis as in the general population (Wright, Doniach, Lessof, Grimble, and Catterall, 1970).…”

Section: Controlsmentioning

confidence: 99%