Tuberculin, Coccidioidin, and Histoplasmin Sensitivity in Relation to Pulmonary Calcifications: A Survey among 6,000 Students at the University of Chicago

Beadenkopf, William G.; Loosli, Clayton G.; Lack, Herbert; Rice, F.A.A.P. Zakiya P.; Slattery, R. V.

doi:10.2307/4586814

Cited by 21 publications

(6 citation statements)

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“…One early investigation, that used skin testing to map the distribution of Coccidioides in the USA, was conducted by Edwards and Palmer in 1957 26. The results of this and similar studies established that the south-central valley of California and the deserts of southern Arizona, were the most highly endemic for Coccidioides 3,18,27. In the future, culture-independent methods, such as multiplex polymerase chain reaction testing of bulk soil samples, may prove to be useful tools to identify Coccidioides locations 28…”

Section: Geographic Rangementioning

confidence: 99%

Coccidioidomycosis: epidemiology

Thompson¹,

Brown²,

Benedict³

et al. 2013

CLEP

140

106

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Coccidioidomycosis consists of a spectrum of disease, ranging from a mild, self-limited, febrile illness to severe, life-threatening infection. It is caused by the soil-dwelling fungi, Coccidioides immitis and C. posadasii, which are present in diverse endemic areas. Climate changes and environmental factors affect the Coccidioides lifecycle and influence infection rates. The incidence of coccidioidomycosis has risen substantially over the past two decades. The vast majority of Coccidioides infections occur in the endemic zones, such as California, Arizona, Mexico, and Central America. Infections occurring outside those zones appear to be increasingly common, and pose unique clinical and public health challenges. It has long been known that elderly persons, pregnant women, and members of certain ethnic groups are at risk for severe or disseminated coccidioidomycosis. In recent years, it has become evident that persons with immunodeficiency diseases, diabetics, transplant recipients, and prisoners are also particularly vulnerable.

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Section: Geographic Rangementioning

confidence: 99%

Coccidioidomycosis: epidemiology

Thompson¹,

Brown²,

Benedict³

et al. 2013

CLEP

140

106

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“…However, the number was lower than the 1,014 cases rep-orted for the corresponding period last year. The cumulative total (3,194) for the current "disease" year was below the corresponding total of 3,968 for last year, the highest year on record. The "disease" year for $cute poliomyelitis begins with the twelftlh week of the calendar year.…”

Section: _1~~9mentioning

confidence: 71%

“…The largest number of people affected, however, fail to show any clinical symptoms of the disease, and( the only evidence that an infection lias been present at some time in the past is sensitivity to the skin-testinig antigen, hiistoplasmiii, and quite frequently, calcified areas in the lungs or hiilar lymphi nodes. Findings of this nature are most common in the States bordering the Mississippi River and its larger tributaries, particularly in the Kansas City area where about 80 percent of the population are positive Ihistoplasmin rieactors (1,2,3).…”

Section: These Include: Further Observations On Histoplasmosismentioning

confidence: 99%

“…ID the clinical histories which follow, information about the six new patients (cases 11-16) is presented in terms of the certainty and possible significance of the diagnosis, rather than in terms of survival, as in the earlier case report study. Follow-up reports of the five surviving patients in the previous group (cases [1][2][3][4][5] are also included to bring the information up to date.…”

Section: These Include: Further Observations On Histoplasmosismentioning

confidence: 99%

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Editorial: Licensure of BCG Vaccine

Anderson¹

1950

Public Health Reports (1896-1970)

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“…Christie and Peterson in a survey of histoplasmin sensitivities at Vanderbilt University recorded 7 positive tests (25.9 percent) among Texans (4). Beadenkopf and his associates, working at the University of Chicago, .I found an incidence of 30 percent among 100 students who had resided in the State of Texas for most of their lives (7). In a study of 200 adults at the Parkland Hospital, Dallas (both in-patients and the hospital personnel were tested), an incidence of 31 percent positive reactors was obseved (8).…”

Section: Discussionmentioning

confidence: 99%

Histoplasmin and Tuberculin Sensitivity in Texas Infants and Children

Forbes¹,

Chang²

1953

Public Health Reports (1896-1970)

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HISTOPLASMOSIS, a disease of variable symptomatology caused by the fungus Histoplasma capsulatwmn, was first described by Darling in 1906 (1). The disease has received increasing attention during the past decade. An increasing number of clinical instances of the disease are being recognized. In 1941, a hlistoplasmin skin test was developed (2, 3). And in 1945 researchers reported that a large number of tuberculin-negative individuals with roentgenographic evidence of pulmonary calcification reacted to the skin test antigen, suggesting that a benign form of the disease exists (4).Extensive skin test surveys have revealed that the percentage of positive reactors among the young adult population is highest in the Ohio, Missouri, and lower Mississippi valley regions and tends to fall off rather sharply with increasing distance from this area, the values varying from 88 percent positive reactors in Kansas City, Mo., to less than 5 percent in the niorthwest and extreme southeastern parts of the United States (5-7).In 1951 histoplasmin skin tests were done on 441 infants and children born in Texas. The

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Tuberculin, Coccidioidin, and Histoplasmin Sensitivity in Relation to Pulmonary Calcifications: A Survey among 6,000 Students at the University of Chicago

Cited by 21 publications

References 0 publications

Coccidioidomycosis: epidemiology

Coccidioidomycosis: epidemiology

Editorial: Licensure of BCG Vaccine

Histoplasmin and Tuberculin Sensitivity in Texas Infants and Children

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