Tubercular lymphadenitis: Clinical manifestations

Seth, Vimlesh; Kabra, Madhulika; Jain, Yogesh; Semwal, O. P.; Mukhopadhyaya, S.; Jensen, Randy L.

doi:10.1007/bf02761878

Cited by 38 publications

(23 citation statements)

References 14 publications

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“…The high incidence of TBL identified in elderly status Aboriginal women has not previously been described in the literature; TBL has most often been reported in young women originating from countries with high endemic rates of TB (6,8,10,22,(26)(27)(28)(29). However, in some high-endemic countries men are more often affected, especially in childhood (17,(30)(31)(32). Cases of TBL in younger, foreign-born patients may illustrate the age of the TB epidemic within this community (9,25,33).…”

Section: Discussionmentioning

confidence: 99%

Tuberculous Lymphadenitis in Manitoba: Incidence, Clinical Characteristics and Treatment

Cook¹,

Manfreda²,

Hershfield³

2004

Canadian Respiratory Journal

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BACKGROUND:Tuberculous lymphadenitis (TBL) is an important form of extrapulmonary tuberculosis (TB). Recent studies have shown an increase in TBL in Canada.OBJECTIVES:To determine the incidence of TBL in Manitoba and to identify the characteristics associated with its presentation, diagnosis and treatment.METHODS:Population data from the Manitoba Health Population Registry, the First Nations and Inuit Health Branch of Health Canada, and Statistics Canada were used to calculate incidence. Case characteristics and outcomes were determined by a systematic, retrospective review of all cases between January 1, 1990 and December 31, 2000.RESULTS:One-hundred forty seven cases of TBL were identified during the study period; 77% confirmed by culture; 68% women. TBL was found in Canadian-born/nonstatus Aboriginal (12%), status Aboriginal (29%) and foreign-born (59%) populations. Incidence of TBL was 1.17 per 100,000 person years (95% CI 0.98 to 1.36). The highest incidence was in status Aboriginals over 65 years (16.85 per 100,000 person years; 95% CI 3.37 to 30.33). TBL is seen most often in Western Pacific women. The most common presentation was a single, enlarged cervical node (80%). No atypical mycobacterium was found. Drug resistance occurred in 13% of cases and only in the foreign-born. Cure rates (81%) were influenced by comorbidity and burden of TB disease. Relapse occurred in 8.1 per 1000 person years of follow-up (95% CI 1.7 to 23.7).CONCLUSIONS:Respiratory physicians, who manage the majority of TB disease in Canada, need to remain aware that TB is an important and treatable cause of enlarged lymph nodes.

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Section: Discussionmentioning

confidence: 99%

Tuberculous Lymphadenitis in Manitoba: Incidence, Clinical Characteristics and Treatment

Cook¹,

Manfreda²,

Hershfield³

2004

Canadian Respiratory Journal

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“…O acometimento tuberculoso dos linfonodos superficiais é uma manifestação comum de tuberculose extrapulmonar em crianças 6,7 . Linfadenite pode ser a única manifestação da doença, e podem não haver sintomas constitucionais associados, como febre de baixa intensidade, perda de peso, tosse ou outros sintomas respiratórios 8 .…”

Section: Introductionunclassified

Children with significant cervical lymphadenopathy: clinicopathological analysis and role of fine-needle aspiration in Indian setup

Khan¹,

Wahab²,

Chana³

et al. 2008

J Pediatr (Rio J)

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ResumoObjetivo: Estudar o perfil clínico-patológico de crianças indianas com linfadenopatia cervical e o papel da citologia aspirativa por agulha fina com ênfase especial na tuberculose como causa. Resultados: A hiperplasia reativa foi o tipo mais comum de linfadenite, seguida da granulomatosa. Os linfonodos do triângulo posterior unilateral foram o grupo afetado com maior freqüência no grupo de linfadenopatia cervical tuberculosa. A aspiração por agulha fina, seguida da coloração de Ziehl-Neelsen, histopatologia e cultura em associação, obteve sucesso em realizar o diagnóstico em 85,7% dos casos de etiologia tuberculosa. Métodos Conclusões:A aspiração por agulha fina é uma ferramenta diagnóstica valiosa no tratamento de crianças com apresentação clínica de linfonodos cervicais aumentados. A técnica reduz a necessidade de procedimentos mais invasivos e dispendiosos, principalmente em países em desenvolvimento.Cultura e histopatologia, entretanto, devem ser consideradas em casos nos quais a citologia aspirativa por agulha fina não é diagnóstica.J Pediatr (Rio J). 2008;84(5):449-454: Linfadenopatia cervical, citologia aspirativa por agulha fina, crianças. AbstractObjective: To study the clinicopathological profile of children from India with cervical lymphadenopathy and the role of fine-needle aspiration cytology with special emphasis on tuberculosis as a cause. Methods:A total of 89 children in the age group of 10 months to 12 years, presenting to our hospital from April 2004 to March 2005, were included. All the patients underwent thorough clinical and investigational assessment vis-à-vis cervical lymphadenopathy. Outcome measurements included clinical status and ability of conventional tests to categorize different types of lymphadenopathy and their utility in diagnosing tubercular lymphadenitis. Interobserver variability was analyzed measuring kappa test and was found to be in agreement. Results:Reactive hyperplasia was the most common type of lymphadenitis, followed by granulomatous involvement. Unilateral posterior triangle lymph nodes were the most commonly affected in the tubercular cervical lymphadenopathy group. Fine-needle aspiration followed by Ziehl-Neelsen staining, histopathology and culture in combination were able to perform the diagnosis in 85.7% of cases affected with tubercular etiology. Conclusions:Fine-needle aspiration is a valuable diagnostic tool in the management of children with the clinical presentation of enlarged cervical lymph nodes. The technique reduces the need for more invasive and costly procedures, especially in a Third World country. Culture and histopathology, however, should be considered in cases where repeated fine-needle aspiration cytology is non-diagnostic.J Pediatr (Rio J). 2008;84(5):449-454: Cervical lymphadenopathy, fine-needle aspiration cytology, children.

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“…The common lymph node groups involved are cervical (75-90%), axillary (14-20%) and inguinal (4-8%). 1,2 On the Indian subcontinent inguinal lymph node involvement is more common than axillary lymph node involvement. 3 Isolated inguinal lymphadenopathy by itself is uncommon and has a varied aetiology.…”

Section: Introductionmentioning

confidence: 99%