Tubercular lymphadenitis and abdominal tuberculosis with autoimmune hemolytic anemia and severe intravascular hemolysis

Somalwar, Ashutosh M; Aher, Archana; Zanwar, Vinay; Kolpakwar, K.S.

doi:10.4103/1755-6783.115182

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“…No adverse effects were reported with steroid use. All survived, except the one patient reported from India in 2013 [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

“…One-third of cases (34%) were reported from India. They were reported from Mangalore, 2016 [ 19 ], Jaipur, 2015 [ 25 ], Bangalore, 2013 [ 27 ], Nagpur, 2013 [ 29 ], Chennai, 2011 [ 31 ], Varanasi, 2005 [ 35 ] and New Delhi, 2004 [ 36 ]. Considering the highest prevalence of TB infection and the highest reporting of TB induced AIHA cases, it is useful to summarize the clinical and laboratory findings from India.…”

Section: Resultsmentioning

confidence: 99%

“…The combination of blood transfusion and steroids was needed in 29%. All survived, except one from Nagpur, 2013 [ 29 ]. PRISMA 2009 checklist is available as Additional file 2 .…”

Section: Resultsmentioning

confidence: 99%

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Tuberculosis induced autoimmune haemolytic anaemia: a systematic review to find out common clinical presentations, investigation findings and the treatment options

Rathish

Siribaddana

2018

Allergy Asthma Clin Immunol

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BackgroundTuberculosis induced autoimmune haemolytic anaemia is a rare entity. The aim of this study was to explore its common presentations, investigation findings and treatment options through a systematic review of published reports.MethodsPubMed, Trip, Google Scholar, Science Direct, Cochrane Library, Open-Grey, Grey literature report and the reference lists of the selected articles were searched for case reports in English on tuberculosis induced auto-immune haemolytic anaemia. PRISMA statement was used for systematic review. Quality assessment of the selected reports was done using the CARE guidelines.ResultsTwenty-one articles out of 135 search results were included. Thirty-three percent of patients were reported from India. More than half had fever and pallor. The mean haemoglobin was 5.77 g/dl (SD 2.2). Positive direct coombs test was seen in all patients. Pulmonary tuberculosis (43%) was most prevalent. Twenty-nine percent of patients needed a combination of anti-tuberculosis medicines, blood transfusion and steroids. Higher percentage of disseminated TB induced AIHA (67%) needed steroids in comparison to the other types of TB induced AIHA (13%).ConclusionsRarer complications of tuberculosis such as auto-immune haemolytic anaemia should be looked for especially in disease-endemic areas. Blood transfusion and steroids are additional treatment options along with the anti-tuberculosis medicines.Electronic supplementary materialThe online version of this article (10.1186/s13223-018-0236-y) contains supplementary material, which is available to authorized users.

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“…No adverse effects were reported with steroid use. All survived, except the one patient reported from India in 2013 [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Tuberculosis induced autoimmune haemolytic anaemia: a systematic review to find out common clinical presentations, investigation findings and the treatment options

Rathish

Siribaddana

2018

Allergy Asthma Clin Immunol

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Tubercular lymphadenitis and abdominal tuberculosis with autoimmune hemolytic anemia and severe intravascular hemolysis

Cited by 1 publication

References 0 publications

Tuberculosis induced autoimmune haemolytic anaemia: a systematic review to find out common clinical presentations, investigation findings and the treatment options

Tuberculosis induced autoimmune haemolytic anaemia: a systematic review to find out common clinical presentations, investigation findings and the treatment options

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