Tubeless Gastric Analysis with Azure A and Betazole Hydrochloride

Witts, L. J.

doi:10.1136/bmj.2.5253.665

Cited by 21 publications

(9 citation statements)

References 13 publications

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“…Finally, applied potential tomography, an impedance measurement technique, can be used to estimate gastric acidity, both basal and stimulated, since the increase of H ions alters the acquired tomographic images of the resistivity of the stomach (14). These non-invasive tests are suitable to assess hypochlorhydria and estimate the amount of acid secretion but do not provide quantitative information about gastric acid (10,(12)(13)(14).…”

Section: Gastric Acid Secretion and Gastric Aciditymentioning

confidence: 98%

“…One of the methods of 'tubeless gastric analysis' is based on dissociation of a cation exchange resin by gastric acid, which is followed by absorption and excretion in the urine (10). Breath tests have been developed in which the final product of the chemical reaction of ingested magnesium metal with gastric acid, hydrogen gas, is measured (11,12).…”

Section: Gastric Acid Secretion and Gastric Aciditymentioning

confidence: 99%

See 1 more Smart Citation

24-h Recording of Intragastric pH: Technical Aspects and Clinical Relevance

Herwaarden¹,

Samsom²,

Smout³

1999

Scandinavian Journal of Gastroenterology

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van Herwaarden MA, Samsom M, Smout AJPM. 24-h recording of intragastric pH: technical aspects and clinical relevance. Scand J Gastroenterol 1999;34 Suppl 230:9-16.Background: Information about gastric acid secretion and gastric acidity can be obtained using several techniques but, presently, continuous intragastric pH recording is probably the one applied most frequently. This paper aims to review the technical aspects and some important applications of intragastric pH monitoring in research and clinical practice. Methods: Literature review. Results: Most studies on intragastric pH are performed with either glass or antimony electrodes. Optimal measurement of 24-h intragastric pH requires accurate calibration of the pH measuring system, exact positioning of the pH electrodes, and a sufficient sample rate. Depending on the aim of the study the results of intragastric pH monitoring are expressed either as median H activity or as median pH values. Gastric acidity shows a circadian rhythm, modified by buffering meals and nocturnal duodenogastric reflux. In health, age, gender and smoking habits are known to influence gastric acidity. In duodenal ulcer disease an increased gastric acidity is found and in patients with gastric ulcer gastric acidity is decreased. In GERD, no relation between reflux oesophagitis and gastric acidity is found. Helicobacter pylori affects intragastric pH most pronounced during acid inhibitory therapy, both in DU patients and in healthy subjects. In the absence of H. pylori the effect of proton-pump inhibitors on intragastric pH is much less than in the presence of the microorganism, whereas the effect of ranitidine on intragastric pH is barely affected by the H. pylori status. Conclusions: Despite some limitations, intragastric pH monitoring provides important information about gastric acidity.

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Section: Gastric Acid Secretion and Gastric Aciditymentioning

confidence: 98%

Section: Gastric Acid Secretion and Gastric Aciditymentioning

confidence: 99%

24-h Recording of Intragastric pH: Technical Aspects and Clinical Relevance

Herwaarden¹,

Samsom²,

Smout³

1999

Scandinavian Journal of Gastroenterology

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“…This method has been tested further in several studies. [51][52][53] Although this test did not quantitatively measure gastric acid, it was felt that the most useful application would be to screen patients for achlorhydria. 51 However, the dye test had two major disadvantages.…”

Section: -38mentioning

confidence: 99%

“…[51][52][53] Although this test did not quantitatively measure gastric acid, it was felt that the most useful application would be to screen patients for achlorhydria. 51 However, the dye test had two major disadvantages. First, it depended upon the functional integrity of the kidney and secondly, patients who tested negative on the test, i.e.…”

Section: -38mentioning

confidence: 99%

Review article: methods of measuring gastric acid secretion

Ghosh

Lewis

Axon

et al. 2011

Alimentary Pharmacology &Amp; Therapeutics

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“…To predict such cases it is necessary to determine gastric acidity by means of an augmented histamine test meal (Kay, 1953), or, if this is not possible, a tubeless test of gastric function such as the Diagnex test (Bock and Witts, 1961). If free acid is present no further investigation of vitamin-B12 status is required.…”

Section: Discussionmentioning

confidence: 99%