Tubal mucosa and ectopic pregnancy

Abstract

Summary. Fallopian tubes containing a gestation are frequently normal on macroscopical and gross histological examination. Scanning electron microscopy and light microscopy studies of tubal biopsies taken from five groups of women showed marked differences in the ciliated surface which was measured planimetrically on photographs. The proportion of ciliated cells was significantly lower in biopsies taken from 25 women with tubal pregnancies compared with that in biopsies from seven women with intrauterine pregnancies at the same gestation. Marked deciliation was also seen in eight women biopsied during tubal surgery sometime subsequent to an ectopic pregnancy and in four women biopsied during tubal surgery who subsequently had a tubal pregnancy when compared with a group of women biopsied during tubal sterilization.

Ectopic pregnancy at Usmanu Danfodiyo University Teaching Hospital Sokoto: A ten year review

“…This finding is similar to reports from previous authors. [4][5][6][7][8][9][10][11][12][13] The reason for this might be explained by the findings of an earlier study, [21] which revealed that all the biopsies from patients with ectopic pregnancies or a history of ectopic pregnancy showed a marked degree of deciliation. It was further explained that loss of ciliated cells from the ampulla may decrease the efficiency of ovum transport, leading to delay in the ovum entering the isthmus and subsequently the uterine cavity.…”

A retrospective study of ectopic pregnancy at a tertiary care centre

“…Ectopic pregnancy commonly occurs in the fallopian tubes (97%). 8 Although women with ectopic pregnancy frequently have no identifiable risk factors, a prospective and case controlled study has shown that increase awareness of ectopic pregnancy and knowledge of the associated risk factors like pelvic inflammatory disease, history of previous ectopic pregnancy, tubal sterilization and any previous pelvic or abdominal surgery help in identifying women at higher risk in order to facilitate early and more accurate diagnosis. 9 Management of the case depends on the clinical presentation, site of the ectopic and need for future reproductive function.…”

The expression of interleukin (IL)-6, IL-8, and their receptors in fallopian tubes with ectopic tubal gestation

“…Conditions causing dysregulation of these signals, such as tubal damage resulting from infection (8)(9)(10), are thought to alter tubal transport and the tubal microenvironment, inducing a receptive phenotype in the FT and predisposing to ectopic pregnancy (2,3). FTs from women with ectopic pregnancy contain less ciliated epithelial cells (2,11).…”