Tubal choriocarcinoma presenting as an ectopic pregnancy

Kant, Anita; Dhanesha, Grishma; Gupta, Usha; Kaul, Amrita Razdan; Kant, Divya

doi:10.4103/tofj.tofj_10_19

Cited by 4 publications

(9 citation statements)

References 8 publications

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“…4 The gold standard diagnosis for choriocarcinoma is a histopathology evaluation in which columns of trophoblastic cells in the absence of villous structures are manifest, compounded by the invasion of blood vessels and muscle tissue, accompanied by extensive necrosis and hemorrhage. 7 The differential diagnosis of tubal choriocarcinoma encompasses other conditions, such as ectopic pregnancy without trophoblastic illness, metastatic gestational choriocarcinoma, primary non-gestational choriocarcinoma, placental site nodule, placental site trophoblastic tumor, and epithelioid trophoblastic tumor. 10 It is of note that immunohistochemistry analysis using BHCG, Ki 67, cytokeratin, placental alkaline phosphates (PLAP), and CD30 can help physicians in differential diagnosis 11 ; however, in the current study, immunohistochemistry was not utilized.…”

Section: Discussionmentioning

confidence: 99%

“…6 A tubal choriocarcinoma may be misdiagnosed with an ectopic pregnancy since both share similar symptoms, including vaginal bleeding, amenorrhea, elevated beta-human chorionic gonadotropin (BHCG) levels, and pelvic pain. 7 Herein, the authors present a rare case of choriocarcinoma in the fallopian tube, for which salpingectomy and chemotherapy were applied as treatment, after which no evidence of recurrence was observed a year after the final chemotherapy session.…”

Section: Introductionmentioning

confidence: 99%

“…The onset of choriocarcinomas may range from 5 weeks to 5 years after gestation or even after menopause 6 . A tubal choriocarcinoma may be misdiagnosed with an ectopic pregnancy since both share similar symptoms, including vaginal bleeding, amenorrhea, elevated beta‐human chorionic gonadotropin (BHCG) levels, and pelvic pain 7 …”

Section: Introductionmentioning

confidence: 99%

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Choriocarcinoma in tubal pregnancy: A case report

Najib,

Bahrami,

Shiravani

et al. 2023

Clinical Case Reports

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Key Clinical MessageChoriocarcinoma of the fallopian tube is extremely rare and highly susceptible to early metastasis. Clinical manifestations of ectopic pregnancy and choriocarcinoma are the same, and all patients with ectopic pregnancy should be evaluated for choriocarcinoma based on histopathological findings. Adjuvant chemotherapy (after surgery) is the proposed treatment for tubal choriocarcinoma.AbstractChoriocarcinoma is a malignant epithelial tumor of the chorionic villi that often manifests after a normal or molar pregnancy. The primary tubal choriocarcinoma associated with ectopic pregnancy is extremely rare and can be misdiagnosed as an ectopic pregnancy since symptoms including vaginal bleeding, amenorrhea, elevated beta‐human chorionic gonadotropin (BHCG) levels, and pelvic pain are shared. A 34‐year‐old G4P3003 woman presented with a one‐week history of vaginal bleeding and right lower abdominal pain, which had intensified a day before admission. Clinical and paraclinical examinations pointed to a ruptured tubal pregnancy; hence, an emergency laparotomy was performed, and a right salpingectomy was carried out on the patient. However, a nonsignificant decline in BHCG level was observed, and histological examination revealed tubal choriocarcinoma; hence, a metastasis workup was carried out, yet no metastasis was detected. Six sessions of chemotherapy consisting of Etoposide, Methotrexate, Dactinomycin, Cyclophosphamide, and Vincristine (EMA‐CO) were administered without complication, in such a way that the BHCG level normalized after three sessions of chemotherapy. Evaluations after 1 year from the completion of chemotherapy revealed that the patient had no subsequent problems. Choriocarcinoma of the fallopian tube is extremely rare and highly susceptible to early metastasis. Clinical manifestations of ectopic pregnancy and choriocarcinoma are the same, and all patients with ectopic pregnancy should be evaluated for choriocarcinoma based on histopathological findings. Metastasis workup should be considered for all individuals with choriocarcinoma. Adjuvant chemotherapy (after surgery) is the proposed treatment for tubal choriocarcinoma.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Choriocarcinoma in tubal pregnancy: A case report

Najib,

Bahrami,

Shiravani

et al. 2023

Clinical Case Reports

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show abstract

“…Choriocarcinoma is a highly malignant tumor arising from neoplastic changes in chorionic villi epithelium. 1 Among patient with choriocarcinoma, 50% follows molar pregnancy whereas approx 30% occurs after miscarriage or an ectopic pregnancy. 1 GTN after a non molar pregnancy is always a choriocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

“…1 Among patient with choriocarcinoma, 50% follows molar pregnancy whereas approx 30% occurs after miscarriage or an ectopic pregnancy. 1 GTN after a non molar pregnancy is always a choriocarcinoma. However, choriocarcinoma occurring after an ectopic pregnancy is very rare and tubal choriocarcinoma associated with an ectopic pregnancy has an aggressive course but still curable.…”

Section: Introductionmentioning

confidence: 99%