Tu1992 Later Chronotype Is Associated With Worse Quality of Life and Biologic Use in Inflammatory Bowel Disease

Dera, Akram E.; Esteban, James; Chakradeo, Prachi; Lee, Alice A.; Burgess, Helen R.; Keshavarzian, Ali; Swanson, Garth

doi:10.1016/s0016-5085(16)33385-6

Cited by 1 publication

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“…Twelve studies met the inclusion criteria ( Basnet et al, 2018 ; Chakradeo et al, 2018 ; Chrobak et al, 2018 ; Ferraz et al, 2008 ; Habers et al, 2021 ; Henry et al, 2017 ; Keskin and Sahbaz, 2020 ; Maidstone et al, 2021b ; Merikanto et al, 2014a , 2014b ; Singh et al, 2016 ; Wohlfahrt et al, 2014 ). The included study characteristics are detailed in Table 1 and the main findings are described in Table 2 and Supplementary Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…Case definition of included IMID patients ranged from self-report of doctor-diagnosed condition to confirmed clinical diagnosis by specialist doctor at secondary care clinics. Four studies independently verified case definitions with data from primary records ( Chakradeo et al, 2018 ; Ferraz et al, 2008 ; Habers et al, 2021 ; Singh et al, 2016 ). Where HCs were used in case-control studies, individuals were identified in the local community with no self-reported IMIDs.…”

Section: Resultsmentioning

confidence: 99%

“…Four studies compared MEQ chronotype in IMID versus HC ( Chakradeo et al, 2018 ; Ferraz et al, 2008 ; Keskin and Sahbaz, 2020 ; Singh et al, 2016 ). In 1 study, an earlier chronotype was more likely in IMID patients compared with HC (IBD), 2 studies found no difference in chronotype (IBD and asthma), and 1 study identified a later chronotype in IMID patients (IBD).…”

Section: Resultsmentioning

confidence: 99%

“…Seven studies investigated the impact of chronotype on IMID quality of life and symptom burden ( Chakradeo et al, 2018 ; Chrobak et al, 2018 ; Habers et al, 2021 ; Merikanto et al, 2014a , 2014b ; Singh et al, 2016 ; Wohlfahrt et al, 2014 ). Five of 7 (71%) studies reported significantly worse morbidity in patients with later chronotypes, using validated metrics such as the Short IBD Questionnaire (SIBDQ), as well as patient-reported symptom burden.…”

Section: Resultsmentioning

confidence: 99%

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Chronotype in Patients With Immune-Mediated Inflammatory Disease: A Systematic Review

et al. 2022

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Immune-mediated inflammatory diseases (IMIDs) such as rheumatoid arthritis, inflammatory bowel disease, and asthma share common pathophysiological pathways characterized by chronic inflammation and subsequent tissue damage involving multiple body sites. Circadian rhythms are 24-h body cycles that regulate immune activity and control the magnitude of immune response based on time of day. Chronotype is a person’s individual circadian phase preference, ranging from morningness to eveningness, which is known to influence the risk of cardiometabolic and mental health disease. We systematically reviewed the literature to assess the association of questionnaire-based chronotype and patients with IMID. A comprehensive search of MEDLINE and Embase identified 12 studies meeting the inclusion criteria, conducted in 7 countries and covering 4 IMIDs to include 15,625 IMID patients and 410,783 healthy controls. Results showed that later chronotype may be a risk factor for worse quality of life and increased symptom burden in patients with IMIDs. In addition, chronotype may be a risk factor for IMID incidence, but the direction and magnitude of this effect were not consistent across individual IMIDs. Chronotype assessment could contribute to risk stratification in patients with IMIDs. Cross-disciplinary collaboration to understand the role of circadian rhythms and chronotype in driving common inflammatory pathways could help to improve outcomes for patients with IMIDs.

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