Tu1725 Predilection Sites of Intestinal Metaplasia in the Stomach: a Retrospective Study Based on Endoscopic Results of 78,335 Cases

Mao, Xin-Yi; Liu, Qing; Zhang, Haihan; Xu, Shaofa; Jiang, Jianxia

doi:10.1016/j.gie.2015.03.1866

Cited by 3 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

Section: Discussionmentioning

confidence: 93%

“…As for sites of lesions, AG, and IM were found most frequently at the angle, lesser curvatures of antrum and corpus in order, and less occurred on fundus, greater curvatures of antrum and corpus. [74][75][76][77] Antrum and corpus may be different in mRNA expression, change patterns of morphometric features and function of acid secretion during the precancerous lesions, [78][79][80] which may lead to significant difference in improvement of AG or IM in the antrum versus corpus, but could not explain the nonsignificant difference in the improvement of AG or IM in the antrum versus corpus after H. pylori eradication. In addition, four studies included in this meta-analysis showed that the improvement of AG and IM discriminated in the greater curvature and the lesser curvature, 36,39,43,81 and all the studies included in this meta-analysis supported that improvement of AG and IM after H. pylori eradication in greater curvature was more significant than in lesser curvature.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Do atrophic gastritis and intestinal metaplasia reverse after Helicobacter pylori eradication?

Liang,

Yang,

Nong

et al. 2023

Helicobacter

View full text Add to dashboard Cite

BackgroundIt's still controversial whether Helicobacter pylori (H. pylori) eradication can reverse atrophic gastritis (AG) and intestinal metaplasia (IM). Therefore, we performed a meta‐analysis to estimate the effect of H. pylori eradication on AG and IM.MethodsWe searched the PubMed, Web of Science and EMBASE datasets through April 2023 for epidemiological studies, which provided mean glandular atrophy (GA) or IM score before and after H. pylori eradication, or provided ORs, RRs or HRs and 95% CIs for the association of AG or IM with H. pylori eradication. Weighted mean difference (WMD) and pooled ORs and 95%CIs were used to estimate the effect of H. pylori eradication on AG and IM.ResultsTwenty articles with a total of 5242 participants were included in this meta‐analysis. H. pylori eradication significantly decreased GA score in the antrum (WMD −0.36; 95% CI: −0.52, −0.19, p < 0.01), GA score in the corpus (WMD −0.35; 95% CI: −0.52, −0.19, p < 0.01), IM score in the antrum (WMD −0.16; 95% CI: −0.26, −0.07, p < 0.01) and IM score in the corpus (WMD −0.20; 95% CI: −0.37, −0.04, p = 0.01). H. pylori eradication significantly improved AG (pooled OR 2.96; 95% CI: 1.70, 5.14, p < 0.01) and IM (pooled OR 2.41; 95% CI: 1.24, 4.70, p < 0.01). The association remained significant in the subgroup analyses by study design, sites of lesions, regions and follow‐up time. Although Publication bias was observed for AG, the association remained significant after trim‐and‐fill adjustment.ConclusionsH. pylori eradication could significantly improve AG and IM at early stage.

show abstract

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Do atrophic gastritis and intestinal metaplasia reverse after Helicobacter pylori eradication?

Liang,

Yang,

Nong

et al. 2023

Helicobacter

View full text Add to dashboard Cite

show abstract

“…In this case, the sampling of material from the incisura angularis is not mandatory [ 9 ]. In support of the need to take material from this additional point, studies show the frequent localization of intestinal metaplasia foci in the area of the incisura angularis [ 15 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

The Impact of the Angulus Biopsy on the Detection of Staging and the Grading of Chronic Gastritis

Khomeriki,

Bordin,

Khomeriki

et al. 2023

Diagnostics

View full text Add to dashboard Cite

There is a generally recognized need for a morphological assessment of the individual risk of developing gastric cancer in a patient with chronic gastritis, according to the OLGA system (Operative Link for Gastritis Assessment). At the same time, the role of assessing the biopsy from the incisura angularis remains controversial. The aim of our study was to assess the value of incisura angularis biopsy in staging gastritis according to the OLGA system by examining the atrophic and inflammatory changes in the antrum, incisura angularis, and body. Materials and Methods: A total of 718 patients (576 women and 142 men) aged 20 to 84 years were examined. Most of the patients were in the age group of 50 to 70 years (54.6%). Depending on the detection of H. pylori and autoimmune gastritis markers, all patients were divided into three groups. The first group included 380 patients with H. pylori gastritis without signs of autoimmune gastritis. The second group consisted of 209 patients with autoimmune gastritis, in whom no infection was detected during the examination, and there were no indications of H. pylori eradication. The third group consisted of 129 patients with chronic gastritis of combined etiology (autoimmune and H. pylori). Endoscopy biopsies were taken according to the updated Sydney System. Histological assessments of the grade and the stage of gastritis were carried out according to the standard OLGA-based protocol. Then, the same assessments were evaluated without taking into account histological changes in the incisura angularis. Results: When assessing the severity of inflammatory changes in the gastric mucosa according to the OLGA system, grade II (72.3%) was most often detected in all groups of patients. A severe degree of activity of chronic gastritis was most often observed in the group of patients with H. pylori gastritis (6.1%). These indicators practically did not change if the assessment did not take the angulus biopsy into account. When assessing the severity of atrophy of the glands in the gastric mucosa in patients of the first group, mild stages of atrophy prevailed. Without taking into account the angulus biopsy, a decrease in the stage of atrophy was observed in 27 cases (7.11%), and in only 4 cases did stage IV change to stage III, while in 23 cases, discrepancies were noted only within groups with a mild stage of atrophy. There were no transitions from stage III to stage II. In the group of patients with autoimmune gastritis, pronounced stages of atrophy prevailed—in more than 77%. Without taking into account the angulus biopsy, a decrease in the stage of atrophy was observed in eight cases (3.83%), and in three (1.4%) patients, stage III was changed to stage II. In the group of patients with combined etiology (autoimmune + H. pylori), severe stages of atrophy also prevailed (70.5%). A decrease in the stage of atrophy without taking into account the angulus biopsy was only observed in three patients (2.32%), of which two cases concerned patients with mild stages of atrophy. Thus, in general, severe stages of atrophy of the gastric mucosa (stages III and IV according to the OLGA staging system) were detected in 313 patients (43.59%). If the assessment of the atrophy stage did not take into account changes in the angulus biopsy, then severe stages of atrophy (III and IV according to OLGA) were detected in 310 patients (43.17%). In total, changes in the assessment of the atrophy stage occurred in 38 patients (5.29%), and this was more often observed in patients with stages I and II of atrophy. Conclusions: Accounting for histological changes in the incisura angularis does not significantly affect the assessment of the grade and stage of chronic gastritis according to the OLGA system, regardless of the etiology of atrophic gastritis.

show abstract

“…и способности вырабатывать цитотоксины, проникают в межклеточные пространства, приводят к повреждению эпителиальных клеток СОЖ и запускают каскад иммуновоспалительных реакций. Гастритические изменения, первоначально поверхностные и локализованные в антральном отделе, со временем распространяются на фундальный отдел, становясь диффузными, и могут в дальнейшем приобретать атрофический характер (с частотой 1-3% ежегодно) с перестройкой эпителия (метаплазией) по кишечному и пилорическому типам [22]. Выявлено, что из 100% больных с Нp-ассоциированным гастритом у 10% на фоне атрофических изменений развивается дисплазия эпителия (предраковое состояние), а у 1-2% -рак желудка.…”

unclassified

Modern aspects of Helicobacter pylori infection

Yakovleva

Смирнова

Korsunskiy

2023

RPJ

View full text Add to dashboard Cite

A systematic review of current data on the structure and functions of Helicobacter pylori (Hp), pathogenesis, diagnosis and treatment of Hp-infection is presented. The relevance of the topic of helicobacteriosis is due to the proven connection of this infection with chronic, widespread diseases of the digestive organs among the population. The review used materials from the databases including PubМed, Medline, EMBASE, Scopus, Google Scholar, RSCI. A systematic review based on studies with a high degree of evidence has shown significant progress in the diagnosis and treatment of Hp-infection in recent years in adults and children. Coordination of the scientific search for the regularities of the formation of Hp-associated forms of pathology, continuous improvement of diagnostic technologies and the search for new therapies, periodic well-organized international revisions of standard methods of Hp diagnosis and treatment contribute to the creation of effective methods of Hp eradication, preservation of the optimal composition of the microbiota of the gastrointestinal tract and prevention of antibiotic resistance. Of particular importance for the prevention of complications of Hp-infection are original diagnostic algorithms using specialized endoscopic and molecular technologies before and after Hp eradication with long-term follow-up and the determination of the leading factors correlating with a high risk of stomach cancer. The review indicates the emergence of potentially effective and promising areas for the diagnosis and treatment of Hp-infection, including genetic modification of the Hp genome to ensure its existence as a human symbiont and a significant reduction in its pathogenic properties. At the same time, sequencing of a new generation reveals mutations in Hp genes associated with its pathogenicity and antibiotic resistance, which contributes to the creation of new classes of drugs to increase the effectiveness of Hp eradication with a decrease in the proportion of antibiotics and an increase in pathogenetically significant inhibitors of its pathogenic factors for the prevention of side effects, a significant reduction in the empirical use of several antibiotics and increased compliance to treatment.

show abstract

Tu1725 Predilection Sites of Intestinal Metaplasia in the Stomach: a Retrospective Study Based on Endoscopic Results of 78,335 Cases

Cited by 3 publications

References 0 publications

Do atrophic gastritis and intestinal metaplasia reverse after Helicobacter pylori eradication?

Do atrophic gastritis and intestinal metaplasia reverse after Helicobacter pylori eradication?

The Impact of the Angulus Biopsy on the Detection of Staging and the Grading of Chronic Gastritis

Modern aspects of Helicobacter pylori infection

Contact Info

Product

Resources

About