Tu1626 – National Trends, Outcomes and Predictors of Mortality in Patients with Ischemic Colitis and Acute Mesenteric Venous Thrombosis. A Nationwide Inpatient Sample Study from 2002 to 2014

Elkafrawy, Ahmed A.; Chauhan, Mahak; Elkaryoni, Ahmed; Othman, Hasan F.; Shah, Raj C.

doi:10.1016/s0016-5085(19)39630-1

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2020

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“… 1 The prevalence of acute intestinal vascular insufficiency, including IC, is 406 of 100,000. 2 Various medications can cause IC through vasoconstriction, hypotension, thrombogenic/procoagulant effect, or direct colonic toxicity. 1 , 3 , 4 Over-the-counter (OTC) systemic nasal decongestants include the alpha-adrenergic agonists pseudoephedrine and oral phenylephrine, which are used for symptomatic relief of nasal congestion in common cold, allergic rhinitis, and sinusitis.…”

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confidence: 99%

Acute Ischemic Colitis due to Oral Phenylephrine

El-Alali

Alhmoud

2020

ACG Case Rep J

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Oral phenylephrine is a commonly used over-the-counter nasal decongestant drug. It is usually taken for symptomatic relief (in combination drug products) for upper respiratory tract infections, allergic rhinitis, or sinusitis. Adverse cardiovascular effects of intravenous phenylephrine, including organ ischemia, are well known; however, oral phenylephrine is rarely associated with significant adverse effects. We describe the first case of acute ischemic colitis in a young patient due to over-the-counter oral phenylephrine, which was taken as a nasal decongestant. We reviewed the literature of colonic ischemia related to the use of systemic nasal decongestants phenylephrine and pseudoephedrine.

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