Tu1373: THE ASSOCIATION BETWEEN THE MEDITERRANEAN DIET AND SYMPTOMS OF IRRITABLE BOWEL SYNDROME

Chen, Ellie Y.; Mahurkar-Joshi, Swapna; Liu, Cathy; Jaffe, Nancee; Labus, Jennifer S.; Gupta, Abha R.; Choo, Charlene; Patel, Shravya; Mayer, Emeran A.; Lin, Chong

doi:10.1016/s0016-5085(22)62226-1

Cited by 2 publications

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“…Intestinibacter may exacerbate urticaria by inducing hypersensitivity reactions through LPS production; however, further research on this potential mechanism is necessary. In a cross‐sectional study by Chen et al., 26 a Mediterranean diet that reduced the risk of urticaria was found to reduce the abundance of the potentially harmful bacterium Intestinibacter 27 …”

Section: Discussionmentioning

confidence: 99%

Investigating causal relationships between the gut microbiota and inflammatory skin diseases: A Mendelian randomization study

Gu,

Zhang,

Zhao

et al. 2024

Aust J Dermatology

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BackgroundNumerous inflammatory skin diseases are associated with the gut microbiota. Studies of the association between gut microbiota and inflammatory skin diseases have yielded conflicting results owing to confounding factors, and the causal relationship between them remains undetermined.MethodsTwo‐sample Mendelian randomization (MR) was used to examine the association between gut microbiota and four common inflammatory skin diseases: acne, psoriasis, urticaria and atopic dermatitis. The summary statistics of the gut microbiota from the largest available genome‐wide association study meta‐analysis (n = 13,266) conducted by the MiBioGen consortium along with the summary statistics of the four diseases were obtained from the FinnGen consortium. Causal relationships were assessed using the inverse variance weighted (IVW), weighted median, MR‐Egger and maximum likelihood methods, and several sensitivity analyses were performed to ensure the accuracy of the results. Finally, reverse and multivariable MR analyses were performed to verify the robustness of the results.ResultsWe found causal associations of Bacteroidaceae [odds ratio (OR), 2.25; 95% confidence interval (CI), 1.48–3.42; pivw = 0.0001], Allisonella (OR, 1.42; 95% CI, 1.18–1.70; pivw = 0.0002) and Bacteroides (OR, 2.25; 95% CI, 1.48–3.42; pivw = 0.0001) with acne, the Eubacterium fissicatena group with psoriasis (OR, 1.22; 95% CI, 1.10–1.35; pivw = 0.0002) and Intestinibacter with urticaria (OR, 1.28; 95% CI, 1.13–1.45; pivw = 0.0001). These results were corrected for a false discovery rate. Sensitivity analyses were performed to validate the robustness of the associations and reverse MR confirmed that the results were not influenced by the reverse effect.ConclusionOur study revealed that some gut microbiota are risk factors for inflammatory skin diseases, providing new information on potential therapeutic targets. Additionally, a possible association with the gut–skin axis was confirmed. Further research is required to elucidate the mechanisms underlying these relationships.

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Section: Discussionmentioning

confidence: 99%

Investigating causal relationships between the gut microbiota and inflammatory skin diseases: A Mendelian randomization study

Gu,

Zhang,

Zhao

et al. 2024

Aust J Dermatology

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“…This cross-sectional study showed that a standard Mediterranean diet was not associated with disease severity, whereas certain Mediterranean foods were associated with symptoms and may not be suitable for all IBS patients, and rather that personalized management was needed for people with severe symptoms. 60 Following this observation, a Mediterranean diet was compared with a low-FODMAP diet and a gluten-free diet, to evaluate feasibility via measures of acceptance and adherence, QOL, and GI symptoms. All three diets improved IBS symptoms and QOL but participants expressed a preference for the Mediterranean diet, likely due to ease of implementation.…”

Section: Adaptation Of the Fodmap Diet: Mediterranean-style Fodmap Dietmentioning

confidence: 99%

Evolution, adaptation, and new applications of the FODMAP diet

O'Brien,

Kasti,

Halmos

et al. 2024

JGH Open

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The FODMAP diet has been a treatment of irritable bowel syndrome (IBS) for many years. Rigorous scientific evaluation and clinical application of the FODMAP diet have generated deep understanding regarding clinical efficacy, mechanisms of action, and potential adverse effects of this dietary approach. In turn, this knowledge has allowed fine‐tuning of the diet to optimize treatment benefits and minimize risks, in the form of the traditional three‐phase diet; the FODMAP‐gentle approach, which is a less restrictive iteration; and a proposed FODMAP‐modified, Mediterranean‐style diet which endeavours to optimise both gastrointestinal symptoms and other health parameters. Furthermore, recognition that IBS‐like symptoms feature in other conditions has seen the FODMAP diet tested in non‐IBS populations, including in older adults with diarrhea and women with endometriosis. These areas represent new frontiers for the FODMAP diet and a space to watch as future research evaluates the validity of these novel clinical applications.

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Tu1373: THE ASSOCIATION BETWEEN THE MEDITERRANEAN DIET AND SYMPTOMS OF IRRITABLE BOWEL SYNDROME

Cited by 2 publications

References 0 publications

Investigating causal relationships between the gut microbiota and inflammatory skin diseases: A Mendelian randomization study

Investigating causal relationships between the gut microbiota and inflammatory skin diseases: A Mendelian randomization study

Evolution, adaptation, and new applications of the FODMAP diet

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