Tu1363 An Open-Label, Pilot Study to Assess Feasibility and Safety of Fecal Microbiota Transplantation in Patients With Mild-Moderate Ulcerative Colitis: Preliminary Results

“…Of those, 29 articles were excluded due to their unclear clinical endpoints, nonspecific data of UC, overlap of data or language restriction. Consequently, 25 studies fulfilled the selection criteria, including 2 RCTs, [ 22 , 23 ] 15 cohort studies [ 32 – 46 ] and 8 case studies [ 47 – 54 ]. Only 6 cohort studies and 3 case studies were abstracts, the other 16 studies were journal articles.…”

Section: Resultsmentioning

confidence: 99%

Fecal Microbiota Transplantation for Ulcerative Colitis: A Systematic Review and Meta-Analysis

et al. 2016

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BackgroundFecal microbiota transplantation (FMT) has been recognized as a novel treatment for ulcerative colitis (UC). However, its efficacy and safety remain unclear.ObjectiveWe conducted this systematic review to assess the efficacy and safety of FMT in UC.Data SourcesPubMed, EMBASE, Cochrane Central, Web of Science Core Collection, and three other Chinese databases were searched for reports of FMT in UC with clear outcomes.Data Extraction and SynthesisWe estimated pooled rates [with 95% confidence interval (CI)] of clinical remission among 15 cohort studies and clinical response among 16 cohort studies.ResultsTwenty five studies (2 randomized controlled trials, 15 cohort studies, and 8 case studies) with 234 UC patients were included. Overall, 41.58% (84/202) patients achieved clinical remission (CR) and 65.28% (126/193) achieved clinical response. Among the cohort studies, the pooled estimate of patients who achieved CR and clinical response were 40.5% (95% CI 24.7%-58.7%), and 66.1% (95% CI 43.7%-83.0%). Most adverse events were slight and self-resolving. The analyses of gut microbiota in 7 studies showed that FMT could increase microbiota diversity and richness, similarity, and certain change of bacterial composition.ConclusionFMT provides a promising effect for UC with few adverse events. Successful FMT may be associated with an increase in microbiota diversity and richness, similarity, and certain change of bacterial composition.

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“…Additionally, among the studies analyzed, only 4 studies used a comparator group against the use of FMT. 11,12,37,52 The remaining studies had the absence of a comparator group limiting the interpretation regarding risk of worsening in disease activity. Thus, despite the extensive literature on the use of FMT in IBD patients, there are a limited number of randomized controlled trials and comparative studies.…”

Section: Discussionmentioning

confidence: 99%

The risk of inflammatory bowel disease flares after fecal microbiota transplantation: Systematic review and meta-analysis

et al. 2017

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Twenty-nine studies with 514 FMT-treated IBD patients were included. Range of follow up was 4 weeks to 3 y. The pooled rate of IBD worsening was 14.9% (95% CI 10-21%). Heterogeneity was detected: I2 D 52.1%, Cochran Q test D 58.1, p D 0.01. A priori subgroup analyses were performed. Although not significant, the pooled rate of worsening in IBD activity following FMT for CDI (22.7% (95% CI: 13-36%)) was higher compared with FMT for IBD (11.1% (95% CI 7-17%)). Rates of worsening in IBD after lower GI FMT delivery revealed a higher rate of worsening in IBD activity (16.5% (95% CI: 11-24%)) compared with upper GI delivery (5.6% (95% CI: 2-16%)). Rates of worsening in high quality studies and randomized controls trials (RCTS) suggested a marginal risk of worsening in IBD activity (4.6%, (95% CI: 1.8-11%). Rates of IBD worsening are overall marginal across high quality RCTS. It is unknown if the FMT itself led to the worsening of IBD in this small fraction or if this represents alternative etiologies.

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Tu1363 An Open-Label, Pilot Study to Assess Feasibility and Safety of Fecal Microbiota Transplantation in Patients With Mild-Moderate Ulcerative Colitis: Preliminary Results

Cited by 9 publications

References 0 publications

Systematic review with meta‐analysis: faecal microbiota transplantation for the induction of remission for active ulcerative colitis

Systematic review with meta‐analysis: faecal microbiota transplantation for the induction of remission for active ulcerative colitis

Fecal Microbiota Transplantation for Ulcerative Colitis: A Systematic Review and Meta-Analysis

The risk of inflammatory bowel disease flares after fecal microbiota transplantation: Systematic review and meta-analysis

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