Tu1291: MASS CYTOMETRY IDENTIFIES A DISCRETE POPULATION OF EFFECTOR MEMORY CD8 T CELLS AS A HALLMARK OF LIVER INJURY DUE TO IMMUNE CHECKPOINT INHIBITORS

Astbury, Stuart; Atallah, Edmond; Bozward, Amber; Krajewska, Natalia; Wootton, Grace; Grove, Jane I.; Franks, Hester; Rao, Ankit; Patel, Poulam M.; Oo, Ye Htun; Aithal, Guruprasad P.

doi:10.1016/s0016-5085(22)63712-0

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2023

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“… 35 We have recently identified a distinct population of circulating effector memory CD8 + cells in patients during an acute phase of ChILI. 36 CPI act upon T cell surface receptors as their therapeutic target which may explain in part the high incidence of irAE such as ChILI. Although rs16906115 near the IL7 locus has been associated with irAE in a genome-wide association study, 37 the variant has not been associated with liver-related adverse events in particular.…”

Section: Discussionmentioning

confidence: 99%