Tu1180 Constipation and a Low Fiber Diet Are Not Associated With Diverticulosis

Peery, Anne F.; Sandler, Robert S.; Ahnen, Dennis J.; Galanko, Joseph A.; Holm, Adrian N.; Shaukat, Aasma; Mott, Leila A.; Barry, Elizabeth L.; Fried, David A.; Baron, John A.

doi:10.1016/s0016-5085(13)62896-6

Cited by 2 publications

(5 citation statements)

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“…First, the study was not population-based and included patients who underwent opportunistic screening colonoscopy. Although recent studies as mentioned above reported similar results to ours [10][11][12][13], these studies also included patients who received colonic polypectomy or opportunistic colorectal cancer screening colonoscopy. Therefore, our study participants, including theirs, were not representative of the general population and further population-based studies should be required to confirm the results.…”

Section: Discussionmentioning

confidence: 61%

“…However, recent studies questioned the association between constipation and diverticulosis. Peery et al conducted a study in the United States and reported that less frequent bowel movements (less than 7/week) were associated with a decreased risk of diverticulosis, compared with regular bowel movements (7/week) [11]. Yamada et al reported that the presence of constipation, defined by Gastrointestinal Symptom Rating Scale (GSRS), was associated with a significantly reduced likelihood of diverticula [12].…”

Section: Discussionmentioning

confidence: 99%

“…Despite the high morbidly and mortality associated with the complications of diverticulosis, the mechanisms underlying the occurrence of this condition remain unclear as they have not been sufficiently investigated. Constipation has widely been considered one of strong factors associated with development of diverticulosis [8,9], but recent studies have questioned this hypothesis [10][11][12][13][14][15]. Peery et al showed that lower bowel movement frequency was associated with a reduced risk of diverticulosis [10,11] and Yamada et al reported that constipation was associated with the absence of diverticula [12,13].…”

Section: Introductionmentioning

confidence: 99%

“…Constipation has widely been considered one of strong factors associated with development of diverticulosis [8,9], but recent studies have questioned this hypothesis [10][11][12][13][14][15]. Peery et al showed that lower bowel movement frequency was associated with a reduced risk of diverticulosis [10,11] and Yamada et al reported that constipation was associated with the absence of diverticula [12,13]. Furthermore, a recent population-based study demonstrated that diarrhea was associated with diverticulosis [14] and Manol et al recently showed an association between bowel movement frequency and risk of diverticulitis in 2 large prospective cohort studies [15].…”

Section: Introductionmentioning

confidence: 99%

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Chronic constipation is negatively associated with colonic diverticula

Higashimori

Nakatani

Jinnai

et al. 2021

Scandinavian Journal of Gastroenterology

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Objectives: Constipation has been considered the key risk factor for diverticulosis occurrence, although the underlying mechanism is unclear. We investigated the factors associated with diverticulosis, focusing on the association of constipation severity with the localization and number of diverticula. Materials and methods:We analyzed consecutive patients who underwent colonoscopy between March and December 2019. Chronic constipation was diagnosed as constipation meeting Rome Ⅳ criteria or as that requiring laxative therapy for more than six months. The degree of constipation was scored using the constipation scoring system (CSS). Results:We assessed 1014 patients. Multivariate analysis revealed that age, alcohol consumption, and hypertension were positively associated with diverticulosis, whereas chronic constipation was negatively associated with diverticulosis (Odds ratio[OR]=0.74, 95% confidence interval [CI] 0.55-0.99). When assessed according to the location of diverticula, right-sided diverticula were significantly associated with a lower incidence of constipation (OR=0.94; 95% CI 0.89-0.98), while neither left-sided nor bilateral diverticula was associated with constipation. This negative association of diverticula with constipation was stronger in patients with high CSS score. In stratified analysis, the number of diverticula decreased with increasing degree of constipation (p for trend <0.01) and a high CSS score was associated with a decreased prevalence of ≧ 3 diverticula (OR=0.64, 95% CI, 0.44-0.99).Conclusions: Chronic constipation was negatively associated with colonic diverticulosis. The association increased with the degree of constipation and was strong only in cases with right-sided diverticula and those with ≧3 diverticula.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Chronic constipation is negatively associated with colonic diverticula

Higashimori

Nakatani

Jinnai

et al. 2021

Scandinavian Journal of Gastroenterology

View full text Add to dashboard Cite

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“…However, it has been demonstrated that constipation and colonic dysmotility do not increase the risk of diverticulosis, let alone diverticulitis. 3 An alternate popular theory suggests that diverticulitis may develop because of trigger foods becoming impacted. A landmark study published in 2008 invalidated the correlation between nuts, corn, and popcorn and diverticulitis.…”

Section: Pathogenesismentioning

confidence: 99%

Diverticulitis: A Review of Current and Emerging Practice-Changing Evidence

Wu,

Al Khaldi,

Richard

et al. 2023

Clin Colon Rectal Surg

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Acute diverticulitis represents a common colorectal emergency seen in the Western world. Over time, management of this condition has evolved. This review aims to highlight recent evidence and update current recommendations. Notable evidence has emerged in certain aspects of diverticulitis. This includes disease pathogenesis, as emerging data suggest a potentially greater role for the microbiome and genetic predisposition than previously thought. Acute management has also seen major shifts, where traditional antibiotic treatment may no longer be necessary for acute uncomplicated diverticulitis. Following successful medical management of acute diverticulitis, indications for elective sigmoidectomy have decreased. The benefit of emergency surgery remains for peritonitis, sepsis, obstruction, and acute diverticulitis in certain immunocompromised patients. Routine colonoscopy, once recommended after all acute diverticulitis episodes, has been shown to be beneficial for cancer exclusion in a distinct patient population. Despite advances in research, certain entities remain poorly understood, such as smoldering diverticulitis and symptomatic uncomplicated diverticular disease. As research in the field expands, paradigm shifts will shape our understanding of diverticulitis, influencing how clinicians approach management and educate patients.

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Tu1180 Constipation and a Low Fiber Diet Are Not Associated With Diverticulosis

Cited by 2 publications

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Chronic constipation is negatively associated with colonic diverticula

Chronic constipation is negatively associated with colonic diverticula

Diverticulitis: A Review of Current and Emerging Practice-Changing Evidence

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