Tu1148 Role of Prucalopride (Resolor®) in the Setting-Up of PillCam Colon-Capsule Endoscopy (CCE). Experience From a Single Centre

Sepe, A.; Grossi, Laurino; Ciccaglione, Antonio Francesco; Tullio, Ada Maria Di; Pagliaro, M.; Tavani, R.; Cocciolillo, Sila; Berardino, M. Di; Marzio, L.

doi:10.1016/s0016-5085(14)62769-4

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“…Prucalopride is a serotonin receptor antagonist that accelerates colonic transit time by increasing peristaltic activity. 11 This prokinetic has been reported to decrease transit time in patients undergoing small bowel capsule endoscopy. 12 …”

Section: Introductionmentioning

confidence: 93%

The Effect of Prucalopride on the Completion Rate and Polyp Detection Rate of Colon Capsule Endoscopies

Deding¹,

Kaalby²,

Baatrup³

et al. 2022

CLEP

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Purpose To investigate whether the prokinetic prucalopride increases the completion rate of colon capsule endoscopy (CCE). Secondary outcomes included demographic distribution, polyp detection rate (PDR), distribution of Leighton–Rex grade, and adverse events. Patients and Methods In a nested cohort within the CareForColon2015 trial, a subgroup of 406 individuals underwent CCE in 2021. The first half (control) received the standard bowel preparation and the second half (prucalopride) was supplemented with 2 mg of prucalopride. Transit times and bowel preparations were analyzed and completion rates calculated as those having timely transit and acceptable bowel cleanliness. Major adverse events were recorded continuously and minor adverse events were quantified from questionnaires. Results The group demographics were homogenous. The prevalence ratio for complete CCE was 1.32 (CI 95% 1.15; 1.53) in the prucalopride group compared to the control group. Completion rate was 74.9% in the prucalopride group and 56.7% in the control group. The proportions of acceptable bowel preparation and complete transits were higher in the prucalopride group. The mean CCE transit time was 2 hours and 8 minutes faster in the prucalopride group. The PDR was higher in the intervention group with 55.7% compared to 36.0% in the control group for polyps greater than 9 mm, whereas the groups’ PDRs were similar for small and diminutive polyps. In all, 589 polyps (mean 2.9) were found in the prucalopride group compared to 522 polyps (mean 2.6) in the control group. Conclusion Prucalopride led to an increase in CCE completion rates. The proportions of complete transits and acceptable bowel preparations were higher in the prucalopride group. The PDR was higher in the prucalopride group compared to the control group. No major adverse events were identified. Nausea, diarrhea, headache and fatigue were more commonly reported in the prucalopride group.

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Section: Introductionmentioning

confidence: 93%