Tu1048 Coagulopathy in Cirrhosis a Prospective Study to Correlate Conventional Tests of Coagulation and Bleeding Following Invasive Procedures in Cirrhotics

Amarapurkar, Deepak; Shah, Apurva; Dharod, Mrudul; Chandanani, Madhuri R.; Baijal, Rajiv; Kumar, Praveen; Jain, Mayank; Patel, N.; Kamani, Praful; Shah, Nimish; Kulkarni, Sandeep; Gautam, Sonali; Doshi, Soham

doi:10.1016/s0016-5085(14)62671-8

Cited by 2 publications

(3 citation statements)

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“…See Characteristics of excluded studies for full details of excluded studies. A total of 23 full-text articles were excluded, of which: nine were trials with non-eligible comparison groups (Alport 2012; Bartelmaos 2013; Corash 2006; Etemadrezaie 2007; Freeman 1998; Holcomb 2015; Mintz 2006; Tinmouth 2008; Williamson 1999)five were non-randomised trials (Amarapurkar 2014; Carino 2009; Friedman 1989; Napolitano 2012; Weigand 2009)three were trials which were withdrawn prior to enrolment (NCT00233246; NCT00953901; NCT01754545)one trial included fewer than 10% of participants receiving central venous catheterisation (De Pietri 2016)one article was a case series (Gallieni 1995)one article was a commentary (Harter 2004)three articles were secondary citations of excluded studies…”

Section: Resultsmentioning

confidence: 99%

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Plasma transfusions prior to insertion of central lines for people with abnormal coagulation

Hall

Estcourt

Dorée

et al. 2016

Cochrane Database of Systematic Reviews

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There is only very limited evidence from one RCT to inform the decision whether or not to administer prophylactic plasma prior to central venous catheterisation for people with abnormal coagulation. It is not possible from the current RCT evidence to recommend whether or not prophylactic plasma transfusion is beneficial or harmful in this situation. The three ongoing RCTs will not be able to answer this review's questions, because they are small studies and do not address all of the comparisons included in this review (355 participants in total). To detect an increase in the proportion of participants who had major bleeding from 1 in 100 to 2 in 100 would require a study containing at least 4634 participants (80% power, 5% significance).

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Section: Resultsmentioning

confidence: 99%

“…five were non-randomised trials (Amarapurkar 2014; Carino 2009; Friedman 1989; Napolitano 2012; Weigand 2009)…”

Section: Resultsmentioning

confidence: 99%

Plasma transfusions prior to insertion of central lines for people with abnormal coagulation

Hall

Estcourt

Dorée

et al. 2016

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

show abstract

“…See Characteristics of excluded studies for further details. Thirteen studies were non-randomised studies (Adorno 1999; Amarapurkar 2014a; Amarapurkar 2014b; Barrera 1996; Barrett 2004; Blumberg 2002; Napolitano 2012; Napolitano 2013; Natalia 2012; Potet 2013; Ray 1997; Weigand 2009; Zeidler 2011)Two studies were reviews (Schiffer 2011; Slichter 2011). One study compared the wrong intervention (OPTIMAL).…”

Section: Resultsmentioning

confidence: 99%

Comparison of different platelet transfusion thresholds prior to insertion of central lines in patients with thrombocytopenia

Estcourt

Desborough

Hopewell

et al. 2015

Cochrane Database of Systematic Reviews

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There is no evidence from RCTs to determine whether platelet transfusions are required prior to central line insertion in patients with thrombocytopenia, and, if a platelet transfusion is required, what is the correct platelet transfusion threshold. Further randomised trials with robust methodology are required to develop the optimal transfusion strategy for such patients. The one ongoing RCT involving people with cirrhosis will not be able to answer this review's questions, because it is a small study that assesses one patient group and does not address all of the comparisons included in this review. To detect an increase in the proportion of participants who had major bleeding from 1 in 100 to 2 in 100 would require a study containing at least 4634 participants (80% power, 5% significance).

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Tu1048 Coagulopathy in Cirrhosis a Prospective Study to Correlate Conventional Tests of Coagulation and Bleeding Following Invasive Procedures in Cirrhotics

Cited by 2 publications

References 0 publications

Plasma transfusions prior to insertion of central lines for people with abnormal coagulation

Plasma transfusions prior to insertion of central lines for people with abnormal coagulation

Comparison of different platelet transfusion thresholds prior to insertion of central lines in patients with thrombocytopenia

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