Tu-P9:355 Asymmetric dimethylarginine and intima-media thickness in hypercholesterolemic subjects

Plasma Asymmetric Dimethylarginine Levels in Healthy People

“…Evidence has been found of correlation between the high ADMA levels and hypercholesterolemia, hypertension, hyperhomocysteinemia, diabetes mellitus, smoking, heart failure, renal and liver failure, erectile dysfunction, etc. [8][9][10][11][12][13][14][15][16] Elevated levels of ADMA correlate with intima-media thickness (IMT) of the carotid artery -the latter being a proven method for clinical assessment of atherosclerosis progression. [17][18][19][20] The correlation of ADMA with cardiovascular morbidity and mortality has been demonstrated in a number of epidemiologic and prospective clinical trials in the recent years.…”

“…[21][22][23] There is also convincing evidence to indicate that ADMA may be correlated with the classic risk factor for ischemic disease. 15,24,25 Because of this ADMA is now considered as a marker of endothelial dysfunction, a candidate for a novel cardiovascular risk factor or an independent risk factor.…”