“…These factors include age, Karnofsky performance status, the extent of the resection, and morphological, histological, and genetic characteristics, such as isocitrate dehydrogenase (IDH) and O(6)-methylguanine-DNA methyltransferase (MGMT) tumor mutation status [40], [41]. When treating with TTFields, it is reasonable to assume that in addition to the factors mentioned above [21], the distribution and intensity of the induced EF in the brain and tumor also influence treatment outcome. The field distribution and intensity may vary significantly between individuals depending on the size, shape, and electrical properties of the head, brain, and tumor.…”