TTDN1 is a Plk1-interacting protein involved in maintenance of cell cycle integrity

Zhang, Yixue; Tian, Yueming; Chen, Q.; Chen, D.; Zhai, Zihan; Shu, Hong‐Bing

doi:10.1007/s00018-007-6501-8

Cited by 31 publications

(18 citation statements)

References 35 publications

(38 reference statements)

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“…Alignment of 70 SIC protein homologs (Supplemental File 1) identified five highly conserved amino acid regions (regions a to e) located at the N-and C-terminal portions of the protein ( Figure 7B), while the central part of the protein is variable. SIC has several predicted functional motifs, including a nuclear localization signal (NLS) at the N terminus, consistent with the observed nuclear accumulation of SIC, and an MPLKIP (M-phase-specific PLK1-interacting protein) motif (SerMetXGluAspXXLeuXPro) near the C terminus (Zhang et al, 2007) ( Figure 7B).…”

Section: Sic Encodes a Conserved Proline/serine-rich Protein Found Insupporting

confidence: 59%

The Arabidopsis sickle Mutant Exhibits Altered Circadian Clock Responses to Cool Temperatures and Temperature-Dependent Alternative Splicing

et al. 2016

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The circadian clock allows plants to anticipate and respond to daily changes in ambient temperature. Mechanisms establishing the timing of circadian rhythms in Arabidopsis thaliana through temperature entrainment remain unclear. Also incompletely understood is the temperature compensation mechanism that maintains consistent period length within a range of ambient temperatures. A genetic screen for Arabidopsis mutants affecting temperature regulation of the PSEUDO-RESPONSE REGULATOR7 promoter yielded a novel allele of the SICKLE (SIC) gene. This mutant, sic-3, and the existing sic-1 mutant both exhibit low-amplitude or arrhythmic expression of core circadian clock genes under cool ambient temperature cycles, but not under light-dark entrainment. sic mutants also lengthen free running period in a manner consistent with impaired temperature compensation. sic mutant alleles accumulate LATE ELONGATED HYPOCOTYL (LHY) and CIRCADIAN CLOCK ASSOCIATED1 (CCA1) splice variants, among other alternatively spliced transcripts, which is exacerbated by cool temperatures. The cca1-1 lhy-20 double mutant is epistatic to sic-3, indicating the LHY and CCA1 splice variants are needed for sic-3 circadian clock phenotypes. It is not expected that SIC is directly involved in the circadian clock mechanism; instead, SIC likely contributes to pre-mRNA metabolism, and the splice variants that accumulate in sic mutants likely affect the circadian clock response to cool ambient temperature.

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Section: Sic Encodes a Conserved Proline/serine-rich Protein Found Insupporting

confidence: 59%

The Arabidopsis sickle Mutant Exhibits Altered Circadian Clock Responses to Cool Temperatures and Temperature-Dependent Alternative Splicing

et al. 2016

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“…These findings also provide further evidence that TTDN1 does not play a role in transcription coupled - NER, unlike photosensitive TTD-associated genes XPD , TTDA and XPB ( Nakabayashi et al 2005 ; Stefanini et al 2010 ). The TTDN1 protein has been reported to interact with Polo-like kinase 1 to help regulate cell cycle progression ( Zhang et al 2007 ), however this has not been confirmed.…”

Section: Resultsmentioning

confidence: 99%

Mutations in the TTDN1 Gene Are Associated with a Distinct Trichothiodystrophy Phenotype

Heller

Khan

Kuschal

et al. 2015

Journal of Investigative Dermatology

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Trichothiodystrophy (TTD) is a rare multisystem disorder, characterized by sulfur deficient hair with alternating dark and light “tiger tail” banding on polarized light microscopy. TTD is caused by mutations in DNA repair/transcription genes XPD, XPB or TTDA, and in TTDN1, a gene of unknown function. While most TTD patients are photosensitive, patients with TTDN1 mutations were reported to be non-photosensitive. We followed a cohort of 36 TTD patients from 2001 to 2013. We describe 5 patients from 4 families with defects in the TTDN1 gene: 4 had no photosensitivity while 1 patient exhibited cutaneous burning. Deep phenotyping of our cohort revealed differences between the patients with and without TTDN1 mutations. Delayed bone age and seizure disorders were overrepresented in the TTDN1 group (p=0.009 and p=0.024, respectively), while some characteristic TTD clinical, laboratory, and imaging findings were absent. The 3 oldest TTDN1 patients displayed autistic behaviors in contrast to the characteristic friendly, socially interactive personality in the other patients. DNA sequencing revealed deletion mutations in TTDN1 ranging in size from a single base pair to over 120kb. These data identify a distinct phenotype relationship in TTD caused by TTDN1 mutations and suggest a different mechanism of disease.

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“…These existing findings suggest that BMP6 may act as a disincentive in the secondary feather follicles morphogenesis of Anser cygnoides via the apoptosis of keratinocytes related to skin development. Polo-like kinase 1 (PLk1) as the highly conserved serine-threonine kinase has important functions in the cell mitosis and the genomic stability (Zhang et al 2007). PLK1 is regarded as the proto-oncogene and the attractive cancer target, which is overexpressed in various range of malignancies such as melanoma, prostate cancer and gastro-instestinal cancer (de Cárcer et al 2018;Bucur et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Characterization of Embryonic Skin Transcriptome in Anser cygnoides at Three Feather Follicles Developmental Stages

Liu

Sello

Sui

et al. 2020

G3 Genes|Genomes|Genetics

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In order to enrich the Anser cygnoides genome and identify the gene expression profiles of primary and secondary feather follicles development, de novo transcriptome assembly of skin tissues was established by analyzing three developmental stages at embryonic day 14, 18, and 28 (E14, E18, E28). Sequencing output generated 436,730,608 clean reads from nine libraries and de novo assembled into 56,301 unigenes. There were 2,298, 9,423 and 12,559 unigenes showing differential expression in three stages respectively. Furthermore, differentially expressed genes (DEGs) were functionally classified according to genes ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and series-cluster analysis. Relevant specific GO terms such as epithelium development, regulation of keratinocyte proliferation, morphogenesis of an epithelium were identified. In all, 15,144 DEGs were clustered into eight profiles with distinct expression patterns and 2,424 DEGs were assigned to 198 KEGG pathways. Skin development related pathways (mitogen-activated protein kinase signaling pathway, extra-cellular matrix -receptor interaction, Wingless-type signaling pathway) and genes (delta like canonical Notch ligand 1, fibroblast growth factor 2, Snail family transcriptional repressor 2, bone morphogenetic protein 6, polo like kinase 1) were identified, and eight DEGs were selected to verify the reliability of transcriptome results by real-time quantitative PCR. The findings of this study will provide the key insights into the complicated molecular mechanism and breeding techniques underlying the developmental characteristics of skin and feather follicles in Anser cygnoides.

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TTDN1 is a Plk1-interacting protein involved in maintenance of cell cycle integrity

Cited by 31 publications

References 35 publications

The Arabidopsis sickle Mutant Exhibits Altered Circadian Clock Responses to Cool Temperatures and Temperature-Dependent Alternative Splicing

The Arabidopsis sickle Mutant Exhibits Altered Circadian Clock Responses to Cool Temperatures and Temperature-Dependent Alternative Splicing

Mutations in the TTDN1 Gene Are Associated with a Distinct Trichothiodystrophy Phenotype

Characterization of Embryonic Skin Transcriptome in Anser cygnoides at Three Feather Follicles Developmental Stages

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