TT virus infection among blood donors and patients with non-B, non-C liver diseases in Korea

Nakano, Tatsunori; Park, Young-Min; Mizokami, Masashi; Choi, Jong-Young; Orito, Etsuro; Ohno, Tomoyoshi; Kato, Takanobu; Kondo, Yutaka; Tanaka, Yasuhito; Kato, Hideaki; Kato, Taichi; Kim, Boo-Sung

doi:10.1016/s0168-8278(99)80095-6

Cited by 30 publications

(16 citation statements)

References 17 publications

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“…Any human disease association is also unclear. Although TTV was originally isolated from a patient with non‐A‐G hepatitis, our studies (data not shown) and others in Europe and Asia 13,22,23 failed to demonstrate an increased prevalence of viremia in patients with liver disease.…”

Section: Discussioncontrasting

confidence: 70%

Prevalence of the newly described human circovirus, TTV, in United States blood donors

et al. 2000

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Section: Discussioncontrasting

confidence: 70%

Prevalence of the newly described human circovirus, TTV, in United States blood donors

et al. 2000

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“…However, a few studies have suggested an association with acute and chronic hepatitis and TTV and HCC. 43,44 Our case-control study enabled us to assess the impact of GBV-C/HGV and TTV in Gabonese patients with HCC. Although the prevalence of GBV-C/HGV and TTV viremia tended to be slightly higher in patients with HCC, it was not significantly different from that of age and sex matched controls.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and genetic variants of hepatitis GB-C/HG and TT viruses in Gabon, equatorial Africa.

Tuveri¹,

Perret²,

Delaporte³

et al. 2000

The American Journal of Tropical Medicine and Hygiene

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Abstract. The distribution of Hepatitis GB-C/HG (GB-C/HG) and TT viruses (TTV) infections was investigated in selected populations from Gabon using Polymerase Chain Reaction (PCR) and Enzyme Linked Immunosorbent Assay (ELISA) for anti-Envelop 2 (anti-E2) GBV-C/HGV antibodies. Among pregnant women, 29 of 229 (12.6%) were Hepatitis GB virus-C and Hepatitis G virus (GBV-C/ HGV) RNA positive (ϩ) and 32 of 81 (39.5%) anti-E2 ϩ versus 8 of 39 (20.5%) TTV DNA ϩ. Among sickle cell anemia patients, 9.7% (3/31) were GBV-C/HGV RNA ϩ versus 22.5% (7/31) TTV DNA ϩ. For tuberculosis patients, the figures were 11.5% (4/35) and 0%. A study of hepatocellular carcinoma cases (n ϭ 27) versus controls (n ϭ 66) did not show significant differences for GBV-C/ HGV RNA (10.7% versus 12.1%) and TTV DNA (44.4% versus 30.3%). According to phylogenetic analysis, the 15 GBV-C/HGV strains investigated clustered in group 1, the most common in sub-Saharan Africa whereas TTV sequences (n ϭ 4) mostly clustered in genotypes G1 and one close to genotype G3. In the Gabonese populations investigated, GBV-C/HGV and TTV infections were highly endemic. These data are consistent with the low pathogenicity of these agents.

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“…Tuveri et al suggested that TTV might be implicated in a few cases of acute and chronic non A-non G hepatitis [113] . However, Nakano et al reported that TTV was not the main causative agent of cryptogenic liver disease [114] . Further efforts at confirming the pathogenecity of hepatocyte damage by TTV are necessary.…”

Section: Ttv Coinfectionmentioning

confidence: 99%

Transfusion transmitted virus: A review on its molecular characteristics and role in medicine

Irshad¹,

Yk²,

Dhar³

2006

WJG

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The present review gives an updated overview of transfusion transmitted virus (TTV), a novel agent, in relation to its molecular characteristics, epidemiological features, modes of transmission, tissue tropism, pathogenesis, role in various diseases and its eradication from the body. TTV, a DNA virus, is a single stranded, non-enveloped, 3.8 kb long DNA virus with a small and covalently closed circular genome comprising 3852 bases. It was tentatively designated Circinoviridae virus.TTV genome sequence is heterogeneous and reveals the existence of six different genotypes and several subtypes. TTV has been reported to transmit not only via parenteral routes, but also via alternate routes. This virus has been detected in different non-human primates as well. At present, TTV is detected by polymerase chain reaction (PCR) with no other available diagnostic assays. It shows its presence globally and was detected in high percent populations of healthy persons as well as in various disease groups. Initially it was supposed to have strong association with liver disease; however, there is little evidence to show its liver tropism and contribution in causing liver diseases. It shows high prevalence in hemodialysis patients, pointing towards its significance in renal diseases. In addition, TTV is associated with several infectious and non-infectious diseases. Although its exact pathogenesis is not yet clear, TTV virus possibly resides and multiplies in bone marrow cells and peripheral blood mononuclear cells (PBMCs). Recently, attempts have been made to eradicate this virus with interferon treatment. More information is still needed to extricate various mysteries related to TTV.

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TT virus infection among blood donors and patients with non-B, non-C liver diseases in Korea

Cited by 30 publications

References 17 publications

Prevalence of the newly described human circovirus, TTV, in United States blood donors

Prevalence of the newly described human circovirus, TTV, in United States blood donors

Prevalence and genetic variants of hepatitis GB-C/HG and TT viruses in Gabon, equatorial Africa.

Transfusion transmitted virus: A review on its molecular characteristics and role in medicine

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